ID | 56067 |
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Author |
Ida, Jun
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kotani, Kazuhiko
Department of Clinical Laboratory Medicine, Department of Community and Family Medicine, Jichi Medical University
Miyoshi, Toru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakamura, Kazufumi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kohno, Kunihisa
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Asonuma, Hirohiko
Department of Cardiology, Kasaoka Diichi Hospital
Sakuragi, Satoru
Department of Cardiology, Iwakuni Clinical Center
Doi, Masayuki
Department of Cardiology, Kgawa Prefectural Central Hospital
Miki, Takashi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Koyama, Yasushi
Department of Cardiology, Sakurabashi Watanabe Hospital
Ito, Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Lipoprotein(a), or Lp(a), is a low-density lipoprotein-like particle largely independent of known risk factors for, and predictive of, cardiovascular disease (CVD). We investigated the association between baseline Lp(a) levels and the progression of coronary artery calcification (CAC) in patients with hypercholesterolemia undergoing statin therapy. This study was a sub-analysis of a multicenter prospective study that evaluated the annual progression of CAC under intensive and standard pitavastatin treatment with or without eicosapentaenoic acid in patients with an Agatston score of 1 to 999, and hypercholesterolemia treated with statins. We classified the patients into 3 groups according to CAC progression. A total of 147 patients (mean age, 67 years; men, 54%) were analyzed. The proportion of patients with Lp(a) > 30 mg/dL significantly increased as CAC progressed (non-progression; 5.4%, 0
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Keywords | lipoprotein(a)
coronary artery calcification
statins
hypercholesterolemia
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2018-06
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Volume | volume72
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Issue | issue3
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Publisher | Okayama University Medical School
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Start Page | 223
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End Page | 230
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID |