ID | 65670 |
FullText URL | |
Author |
Shimanouchi, Toshinori
Department of Environmental Chemistry and Materials, Okayama University
ORCID
Kaken ID
researchmap
Komori, Yui
Department of Environmental Chemistry and Materials, Okayama University
Toramoto, Kazuki
Department of Environmental Chemistry and Materials, Okayama University
Hayashi, Keita
National Institute of Technology, Nara College
Yasuhara, Kazuma
Division of Materials Science, Nara Institute of Science and Technology (NAIST)
Jung, Ho-Sup
Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University
Kimura, Yukitaka
Department of Environmental Chemistry and Materials, Okayama University
|
Abstract | The Span 40 (sorbitan monooleate)/Tween 40 (polyoxyethylene sorbitan monolaurate) system gives faceted vesicles with angular surfaces, rather than spherical vesicles. Herein, a continuous and facile preparation method, based on the subcritical water-assisted emulsification and solvent diffusion, was presented to yield faceted vesicles with two major and minor axes (Type A) and vesicles closer to a polyhedron (Type B). Type A, rather than Type B, vesicles were likely to be formed. From the measurements concerning & zeta;-potential, membrane fluidity, and the polarization environment of the membranes, faceted vesicles could be obtained at 0.25 wt% of the surfactant concentration. The phase-separated behavior of Span 40 and Tween 40 within vesicle membranes could explain the structural feature of faceted vesicles and calcein leakage behavior. The significant advantage is that Type A vesicles would be utilized as alternative drug carriers for others with low encapsulation efficiency, although the present technical limitations cause difficulty in the selective formation of Type A and B vesicles and the selection of adequate solvent to accelerate the solvent diffusion step.
|
Keywords | vesicles
subcritical water
emulsification
solvent diffusion
|
Published Date | 2023-06-07
|
Publication Title |
Applied Sciences
|
Volume | volume13
|
Issue | issue12
|
Publisher | MDPI
|
Start Page | 6893
|
ISSN | 2076-3417
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2023 by the authors.
|
File Version | publisher
|
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.3390/app13126893
|
License | https://creativecommons.org/licenses/by/4.0/
|
Citation | Shimanouchi, T.; Komori, Y.; Toramoto, K.; Hayashi, K.; Yasuhara, K.; Jung, H.-S.; Kimura, Y. Hydrothermal Preparation of Faceted Vesicles Made of Span 40 and Tween 40 and Their Characterization. Appl. Sci. 2023, 13, 6893. https://doi.org/ 10.3390/app13126893
|