ID | 66170 |
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Shinoda-Ito, Yuki
Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Omori, Kazuhiro
Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Ito, Takashi
Center for Innovative Clinical Medicine, Okayama University Hospital
Nakayama, Masaaki
Department of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Ikeda, Atsushi
Department of Periodontics & Endodontics, Division of Dentistry, Okayama University Hospital
Ito, Masahiro
Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Ohara, Toshiaki
Department of Pathology and Experimental Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Takashiba, Shogo
Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | Dental caries are an oral infectious disease that can affect human health both orally and systemically. It remains an urgent issue to establish a novel antibacterial method to prevent oral infection for a healthy life expectancy. The aim of this study was to evaluate the inhibitory effects of novel iron chelators, super-polyphenols (SPs), on the cariogenic bacterium Streptococcus mutans, in vitro. SPs were developed to reduce the side effects of iron chelation therapy and were either water-soluble or insoluble depending on their isoforms. We found that SP6 and SP10 inhibited bacterial growth equivalent to povidone-iodine, and viability tests indicated that their effects were bacteriostatic. These results suggest that SP6 and SP10 have the potential to control oral bacterial infections such as Streptococcus mutans.
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Keywords | antimicrobial
iron chelator
oral infection
Streptococcus mutans
super-polyphenols
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Published Date | 2023-10-24
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Publication Title |
Antibiotics
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Volume | volume12
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Issue | issue11
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Publisher | MDPI
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Start Page | 1562
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ISSN | 2079-6382
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2023 by the authors.
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3390/antibiotics12111562
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License | https://creativecommons.org/licenses/by/4.0/
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Citation | Shinoda-Ito, Y.; Omori, K.; Ito, T.; Nakayama, M.; Ikeda, A.; Ito, M.; Ohara, T.; Takashiba, S. Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic Streptococcus mutans. Antibiotics 2023, 12, 1562. https://doi.org/10.3390/antibiotics12111562
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Funder Name |
Japan Society for the Promotion of Science
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助成番号 | 19K18961
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