ID | 65039 |
FullText URL | |
Author |
Hirami, Yuki
Department of Nursing, Okayama University Graduate School of Health Sciences
Nishimura, Midori Filiz
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Urata, Tomohiro
Department of Hematology and Oncology, Okayama University Hospital
Morimoto, Michiko
Department of Nursing, Okayama University Graduate School of Health Sciences
Maekawa, Yukina
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Nishimura, Yoshito
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sato, Yasuharu
Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
ORCID
Kaken ID
researchmap
|
Abstract | Intravascular large B-cell lymphoma (IVL) is a rare type of lymphoma characterized by tumor growth selectively within the vessels. The 5th edition of the World Health Organization classification defines IVL as a large B-cell lymphoma, the same as diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). Since the clinical manifestations of IVL are nonspecific, the diagnosis is time-consuming, and the course is often fatal. Serum soluble interleukin-2 receptor (sIL-2R) and serum lactate dehydrogenase (LDH) levels are known to be elevated in a variety of lymphomas. However, the mechanism of sIL-2R elevation in B-cell lymphomas is not fully understood. In this study, we analyzed the serum level of laboratory findings, including sIL-2R and LDH, as well as the presence of B symptoms in 39 patients with IVL, and compared them with 56 patients with stage IV DLBCL. Both sIL-2R and LDH levels were significantly higher in IVL than in DLBCL (p = 0.035 andp = 0.002, respectively). In IVL, there were no significant differences in both sIL-2R and LDH levels between patients with and without B symptoms (p = 0.206 andp = 0.441, respectively). However, in DLBCL, both sIL-2R and LDH levels were significantly higher in the presence of B symptoms (p = 0.001 andp < 0.001, respectively). The high sIL-2R and LDH levels in IVL may be related to the peripheral blood microenvironment, but further studies are needed to verify this.
|
Keywords | intravascular large B-cell lymphoma
diffuse large B-cell lymphoma
soluble interleukin-2 receptor
lactate dehy-drogenase
B symptoms
|
Published Date | 2023
|
Publication Title |
Journal of Clinical and Experimental Hematopathology
|
Volume | volume63
|
Issue | issue1
|
Publisher | Japanese Society for Lymphoreticular Tissue Research
|
Start Page | 25
|
End Page | 31
|
ISSN | 1346-4280
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2023 The Japanese Society for Lymphoreticular Tissue Research
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.3960/jslrt.22043
|
License | https://creativecommons.org/licenses/by-nc-sa/4.0/
|