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ID 61871
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Yamashita, Koichiro Graduate School of Natural Science and Technology, Okayama University
Tanaka, Tenu Graduate School of Natural Science and Technology, Okayama University
Matsuo, Toshihiko Graduate School of Interdisciplinary Science and Engineering in Health Systems ORCID Kaken ID publons researchmap
Uchida, Tetsuya Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
Retinal prostheses have been developed to restore vision in blind patients suffering from such diseases as retinitis pigmentosa. In our previous studies, we developed a retinal prosthesis called dye-coupled film by chemical coupling of photoelectric dyes, which absorb light and then generate electrical potential, with a polyethylene film surface. The dye-coupled film is nontoxic, and we recovered the vision of a monkey with macular degeneration. The amount of dye on the dye-coupled film, however, decreased to one-third after five months in the monkey’s eye. The photoelectric dye consists of a cation with photoresponsivity and a bromide ion (Br−). Therefore, an anion-exchange reaction could be applied to the dye-coupled film to improve its durability. In this study, the anion-exchange reaction was conducted using bis(trifluoromethanesulfonyl)imide ion (TFSI−), which has lower nucleophilicity than Br−. First, the long-term durability was examined without using animal subjects and in a short period. Subsequently, an elemental analysis was performed to confirm the exchange between Br− and TFSI−, and chemical properties, such as photoresponsivity and durability, before and after the anion exchange, were evaluated. It was quantitatively confirmed that the long-term durability of dye-coupled films can be evaluated in an in vitro environment and in a short period of one-thirtieth by utilizing a saline solution at 60°C, compared with an in vivo environment. In addition, the durability of the dye-coupled film with TFSI− was improved to 270%–320% compared with that of the dye-coupled film with Br−.
Keywords
retinal prosthesis
photoelectric dye
polyethylene film
retinitis pigmentosa
durability
Note
This is an Accepted Manuscript of an article published by IOP
This fulltext is available in March 2022
Published Date
2021-3-8
Publication Title
Biomedical Materials
Volume
volume16
Issue
issue4
Publisher
IOP Publishing
Start Page
045001
ISSN
1748-6041
NCID
AA12157402
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
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author
PubMed ID
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Related Url
isVersionOf https://doi.org/10.1088/1748-605x/abe809
Funder Name
Japan Society for the Promotion of Science
助成番号
19J13826