ID | 58286 |
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Author |
Katayama, Norihisa
Department of Radiology, Okayama University Graduate School of Medicine
Kaken ID
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Yorozu, Atsunori
Department of Radiation Oncology, National Hospital Organization Tokyo Medical Center
Maruo, Shinichiro
Translational Research Informatics Center
Kojima, Shinsuke
Translational Research Informatics Center
Ohashi, Toshio
Department of Radiation Oncology, Keio University School of Medicine
Tanaka, Nobumichi
Department of Urology, Nara Medical University School of Medicine
Kikuchi, Takashi
Translational Research Informatics Center
Higashide, Satoshi
Translational Research Informatics Center
Saito, Shiro
Department of Urology, National Hospital Organization Tokyo Medical Center
Dokiya, Takushi
Department of Radiology, Kyoundo Hospital
Fukushima, Masanori
Institutes of Preventive Medicine, Kurosawa Hospital
Yamanaka, Hidetoshi
Translational Research Informatics Center
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Abstract | Purpose: To evaluate the incidence and the associated factors of rectal toxicity in patients with prostate cancer undergoing permanent seed implantation (PI) with or without external beam radiation therapy (EBRT) in a nationwide prospective cohort study in Japan (J-POPS) during the first 2 years.
Methods and materials: A total of 2,339 subjects were available for the analyses. Rectal toxicity was evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0. Results: The 3-year cumulative incidence for grade ≥2 rectal toxicity was 2.88%, 1.76%, and 6.53% in all subjects, PI group and EBRT combination therapy group, respectively. On multivariate analysis, among all subjects, grade ≥2 rectal toxicity was associated with rectal volumes receiving 100% of the prescribed dose (R100; p < 0.0001) and EBRT combination therapy (p = 0.0066). R100 in the PI group (p = 0.0254), and R100 (p = 0.0011) and interactive planning (p = 0.0267) in the EBRT combination therapy group were also associated with grade ≥2 toxicity. The 3-year cumulative incidence of grade ≥2 rectal toxicity was 3.80% and 1.37% for R100 ≥ 1 mL and R100 < 1 mL, respectively, in the PI group (p = 0.0068), and 14.09% and 5.52% for R100 ≥ 1 mL and R100 < 1 mL, respectively, in the EBRT combination therapy group (p = 0.0070). Conclusions: Rectal toxicity was relatively rare in this study compared with previous reports. For Japanese prostate cancer patients, R100 < 1 mL in both PI and EBRT combination therapy groups and interactive planning in EBRT combination therapy group may be effective in decreasing the incidence of rectal toxicity. |
Keywords | Brachytherapy
Dose-volume histogram parameters
External beam radiation therapy
Interactive planning
Prostate cancer
Rectal toxicity
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Published Date | 2016-10-05
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Publication Title |
Brachytherapy
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Volume | volume15
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Issue | issue6
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Publisher | Elsevier
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Start Page | 736
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End Page | 745
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ISSN | 1538-4721
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NCID | AA11694304
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1016/j.brachy.2016.09.001
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Citation | Katayama N, Yorozu A, Maruo S, et al. Predictive factors of rectal toxicity after permanent iodine-125 seed implantation: Prospective cohort study in 2339 patients. Brachytherapy. 2016;15(6):736‐745. doi:10.1016/j.brachy.2016.09.001
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