ID | 61707 |
FullText URL | |
Author |
Ishikawa, Takashi
Department of Breast Surgery and Oncology, Tokyo Medical University
Sakamaki, Kentaro
Department of Biostatistics, Yokohama City University
Narui, Kazutaka
Department of Biostatistics, Yokohama City University
Nishimura, Hideki
Department of Biostatistics, Yokohama City University
Sangai, Takafumi
Department of Breast and Thyroid Surgery, Chiba University
Tamaki, Kentaro
Naha-Nishi Clinic
Hasegawa, Yoshie
Department of Breast Surgery, Hirosaki Municipal Hospita
Watanabe, Ken-ichi
Department of Breast Surgery, Hokkaido Cancer Center
Suganuma, Nobuyasu
Department of Breast and Thyroid Surgery, Kanagawa Cancer Center
Michishita, Shintaro
Department of Breast Surgery, Yao Municipal Hospital
Sugae, Sadatoshi
Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine
Aihara, Tomohiko
Breast Center, Aihara Hospital
Tsugawa, Koichiro
Department of Breast and Thyroid Surgery, St. Marianna University
Kaise, Hirose
Department of Breast Surgery and Oncology, Tokyo Medical University
Taira, Naruto
Department of Breast and Endocrinology Surgery, Okayama University Graduate School of Medicine
Kaken ID
publons
Mukai, Hirofumi
Division of Oncology/Hematology, National Cancer Center Hospital East
|
Abstract | Background
As Asians are more vulnerable to febrile neutropenia (FN) than Caucasians, evaluations of FN incidence and risk factors in Asians are important for the appropriate use of primary pegfilgrastim (PEG-G). Patients and methods Japanese breast cancer patients receiving standard adjuvant chemotherapies were prospectively enrolled in multicenter institutions from August 2015 to July 2017. FN was evaluated from 2 treatment policies: true FN (T-FN): ≥37.5 °C, grade 4 neutropenia, mandatory hospital visit (visiting); surrogate FN (S-FN): ≥37.5 °C, oral antibiotic, no mandatory visit (non-visiting). PEG-G was used at the physicians’ discretion. The primary endpoint was FN incidence during all cycles. Multivariate logistic regression analysis was performed to identify T-FN risk factors. Results Of 1005 enrolled patients, 980 women treated with FEC, E(A)C, and TC were analyzed. The FN incidence proportions in all patients were 22.5%, 27.5%, and 33.9% for FEC, E(A)C, and TC, respectively. Those of T-FN were 27.7%, 22.4%, and 36.6%; those of S-FN were 17.3%, 32.4%, and 31.5% with more frequent primary PEG-G usage. The relative dose intensity (RDI) of the 3 regimens was ≥0.85 in both groups. In the analysis of risk factors, TC (odds ratio = 2.67), age ≥ 65 years (2.24), and pretreatment absolute neutrophil count (ANC)/1000 μl (0.8) remained significant. Conclusions FN incidences were above 20% in the 3 regimens, with TC showing the highest. RDI was maintained at a high level in both visiting and non-visiting groups. Patient-related risk factors were age and pretreatment ANC. |
Keywords | Breast cancer
Febrile neutropenia
Adjuvant chemotherapy
Risk factors
Prospective study
|
Published Date | 2021-04-30
|
Publication Title |
The Breast
|
Volume | volume56
|
Publisher | Elsevier
|
Start Page | 70
|
End Page | 77
|
ISSN | 09609776
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | © 2021 The Author(s).
|
File Version | publisher
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.1016/j.breast.2021.01.005
|
License | http://creativecommons.org/licenses/by-nc-nd/4.0/
|
Citation | Takashi Ishikawa, Kentaro Sakamaki, Kazutaka Narui, Hideki Nishimura, Takafumi Sangai, Kentaro Tamaki, Yoshie Hasegawa, Ken-ichi Watanabe, Nobuyasu Suganuma, Shintaro Michishita, Sadatoshi Sugae, Tomohiko Aihara, Koichiro Tsugawa, Hirose Kaise, Naruto Taira, Hirofumi Mukai, Prospective cohort study of febrile neutropenia in breast cancer patients administered with neoadjuvant and adjuvant chemotherapies: CSPOR-BC FN study, The Breast, Volume 56, 2021, Pages 70-77, ISSN 0960-9776, https://doi.org/10.1016/j.breast.2021.01.005.
|
Open Access (Publisher) |
OA
|
Open Archive (publisher) |
Non-OpenArchive
|