ID | 62224 |
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Otsuka, Yuki
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hagiya, Hideharu
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
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Nakano, Yasuhiro
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Omura, Daisuke
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hasegawa, Kou
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yamada, Haruto
Department of Laboratory Medicine, Okayama City Hospital
Iio, Koji
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Honda, Tomoyuki
Department of Virology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | The gold standard for the diagnosis of coronavirus disease 2019 (COVID-19) is a nucleic acid detection test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may occasionally reveal false-positive or false-negative results. Herein, we describe the case of a patient infected with human coronavirus NL63 (HCoV-NL63) who was falsely diagnosed with COVID-19 using the Ampdirect™ 2019-nCoV detection kit (Shimadzu Corporation, Japan) and admitted to a COVID-19 hospital ward. We suspected a cross-reaction between HCoV-NL63 and SARS-CoV-2; however, the reported genome sequences of HCoV-NL63 and N1/N2 primers for SARS-CoV-2 do not correspond. Thus, the patient was supposed to be false positive by the instrument, possibly due to contamination. Although the issue of a false-negative result has been the focus of much attention to prevent the spread of the disease, a false positive is fraught with problems as well. Physicians should recognize that unnecessary isolation violates human rights and a careful diagnosis is indispensable when the results of laboratory testing for COVID-19 are unclear, for instance if the duplicate PCR test is partially positive or the CT value is high.
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Keywords | Human coronavirus
Coronavirus disease 2019
Severe acute respiratory syndrome coronavirus 2
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Note | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/.
This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jiac.2021.05.001
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Published Date | 2021-7
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Publication Title |
Journal of Infection and Chemotherapy
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Volume | volume27
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Issue | issue7
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Publisher | Elsevier BV
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Start Page | 1126
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End Page | 1128
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ISSN | 1341-321X
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NCID | AA11057978
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1016/j.jiac.2021.05.001
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License | https://creativecommons.org/licenses/by-nc-nd/4.0
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