ID | 55197 |
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Okada, Masahiro
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kaken ID
Nakai, Akira
Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Hara Emilio, Satoshi
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Taguchi, Tetsushi
Polymeric Biomaterials Group, RCFM, National Institute for Materials Science
Nakano, Takayoshi
Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
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Abstract | Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues.
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Keywords | Hydroxyapatite
Nanoparticle
Solid adhesive
Wet adhesion
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Published Date | 2017-05
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Publication Title |
Acta Biomaterialia
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Volume | volume57
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Publisher | Elsevier B.V.
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Start Page | 404
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End Page | 413
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ISSN | 1742-7061
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NCID | AA12033647
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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File Version | author
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Related Url | https://doi.org/10.1016/j.actbio.2017.05.014
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