ID | 30009 |
FullText URL | |
Author |
Shinji, Toshiyuki
Yumoto, Eichiro
Ono, Toshiro
Kaken ID
researchmap
Koide, Norio
|
Abstract | Background: Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulinlike
growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and one intronic. We previously reported a hot spot of promoter hypermethylation of IGFBP-3 in
human hepatocellular carcinomas and derivative cell lines. As the hot spot locates at the putative upstream p53 consensus sequences, these p53 consensus sequences are really functional is a question to be answered. |
Note | Digital Object Identifer:10.1186/1471-2407-5-9
Published with permission from the copyright holder. This is the institute's copy, as published in BMC Cancer, 20 January 2005, 5:9. Publisher URL:http://dx.doi.org/10.1186/1471-2407-5-9 © 2005 Hanafusa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Published Date | 2005-01-20
|
Publication Title |
BMC Cancer
|
Volume | volume5
|
Publisher | BioMed Central
|
ISSN | 1471-2407
|
NCID | AA12034763
|
Content Type |
Journal Article
|
language |
English
|
Copyright Holders | Hanafusa et al; licensee BioMed Central Ltd.
|
File Version | publisher
|
Refereed |
True
|
DOI | |
PubMed ID | |
Web of Science KeyUT | |
Submission Path | surgery/2
|