ID | 13718 |
Eprint ID | 13718
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FullText URL | |
Title Alternative | Suppression of liver metastasis by biological response modifiers (BRMs) and the significance of local immunity in the liver
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Author |
Takahashi, Masahiko
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Abstract | Efficacy of a combination therapy with two biological response modifiers (BRMs), oral PSK and systemic IL-2, was evaluated in a mouse model system of hepatic metastasis from colon cancer. Hepatic metastasis was significantly suppressed and the duration of survival was significantly prolonged by combination therapy, but not by either therapy alone. The therapeutic effects were attributable to the mechanism that non-MHC restricted cytotoxicity of hepatic non-parenchymal lymphocytes activated by IL-2 was augmented by PSK-activated Kupffer cells with direct cell-to-cell contact. These results suggest that local immunity in the liver plays an important role in the formation and development of hepatic metastasis and that the combination of these two BRMs may provide an effective new clinical therapy.
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Keywords | 肝移転
肝リンパ球
クッパー細胞
PSK
interleukin 2 (IL-2)
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Note | 原著
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Published Date | 1996-06-29
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume108
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Issue | issue3-6
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 129
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End Page | 137
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/108/3-6/108_3-6_129/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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