ID | 13782 |
Eprint ID | 13782
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FullText URL | |
Title Alternative | T-cell subsets in lung tissue and BALF from patients with interstitial pneumonia
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Author |
Namba, Jiro
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Abstract | The cellular components in bronchoalveolar lavage fluids (BALF) and biopsied lung tissues of patients with various types of interstitial pneumonia were analyzed to clarify cellular kinetics in the lung. The T-cell subsets of lymphocytes in BALF and biopsied lung tissues were examined in 7 cases of hypersensitivity pneumonitis (HP), 2 cases of sarcoidosis (Sar), one case of idiopathic interstitial pneumonia (IIP) and 2 cases of rheumatoid arthritis with interstitial pneumonia (RA+IP). The T-cell subsets in BALF were analyzed by flow cytometry and the T-cell subsets in lung tissue were detected in frsh frozen and thin-sliced specimens using an avidine-biotine complex (ABC) kit. The mean CD4/CD8 ratio in BALF was 0.36 in HP, 3.1 in Sar, 1.07 in IIP and 2.59 in RA+IP, while the mean CD4/CD8 ratio in lung tissues was 0.52 in HP, 2.59 in Sar, 1.11 in IIP and 2.25 in RA+IP, respectively. The ratios of CD4/CD8 in BALF and lung tissues from patients with these various interstitial pneumonia showed a positive correlation. Significant correlation was seen between CD4/CD8 rations of the alveolar portion findings indicate that BAF findings reflect the changes in the lung tissues, although BALF might reflect only a part of the changes in the whole lung.
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Keywords | bronchoalveolar lavage (BAL)
transbronchial lung biopsy (TBLB)
immunoperoxidase staining
T-cell subset
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Note | 原著
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Published Date | 1994-02
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume106
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Issue | issue1-2
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 23
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End Page | 32
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | http://www.https://www.jstage.jst.go.jp/article/joma1947/106/1-2/106_1-2_23/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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