| ID | 13829 |
| Eprint ID | 13829
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| FullText URL | |
| Title Alternative | Effects of δ-Guanidinovaleric acid and GABA agonists on monoamine release in rat striatum
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| Author |
Iwaya, Kazuo
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| Abstract | δ-Guanidinovaleric acid (GVA) is an endogenous convulsant and is thought to be a specific GABA antagonist. In the present study, we examined the effects of GVA and GABA agonists, GABA, muscimol and baclofen, on dopamine and serotonin releases in rat striatum using a brain dialysis technique. GVA produced a significant increase in DA released transiently (1mM) and throughout the experiment (10mM) compared with the controls. It also produced a significant increase in 5-HT release in both concentrations throughout the experiment. GABA (10mM) inhibited DA and 5-HT releases induced by GVA. Muscimol (10mM) inhibited DA and 5-HT releases induced by GVA. Especially muscimol was more effective in the inhibition of 5-HT release. Baclofen (10mM) inhibited only DA release induced by GVA. These results suggest that the activation of GABA receptor inhibits the release of DA and 5-HT in the striatum, and that the DAergic system regulates the GABA-B receptor while the 5-HTergic system mainly regulates the GABA-A receptor.
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| Keywords | δ-Guanidinovaleric acid
GABA(A) receptor
GABA(B) receptor
Serotonin
Dopamine
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| Note | 原著
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| Published Date | 1994-10
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume106
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| Issue | issue9-10
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 985
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| End Page | 1002
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/106/9-10/106_9-10_985/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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