ID | 17572 |
Eprint ID | 17572
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FullText URL | |
Title Alternative | Metabolism of 4-amino-3-hydroxybutanoic acids in the mouse organs and their inhibitory effects on penicillin-induced spike activity of the cat cerebral cortex and on electrical activity of an identified snail giant neurone
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Author |
Katayama, Yasuto
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Abstract | 1) 1-(14)C labelled (3R)-(-)-4-amino-3-hydroxybutanoic acid (l-GABOB) and (3S)-(+)-4-amino-3-hydroxybutanoic acid (d-GABOB) were prepared from their racemic compound using
camphor-10-sulfonic acid. These optical isomers were administered at the dose of 5.6μCi(1mg)
to mice intraperitoneally and observed that l-GABOB was uptaken more rapidly into blood and organs, and metabolized more rapidly in the liver and kidney than d-GABOB, and that l-GABOB could penetrate significantly into the brain, while d-GABOB could hardly do it. 2) These substances in the concentration of 10(-3)M were topically applied on the epileptogenic focus of the cat cerebral cortex induced by potassium benzyl penicillin. As the results of the experiment, no more spike was observed several minutes after l-GABOB administration (n=6, all cases). On the contrary, the optical isomer, d-GABOB, showed a very weakly effect (Spike counts were reduced to 64.5±3.8%, n=6, P<0.05), and racemic GABOB moderately (Spike counts were reduced to 16.4±5.5%, n=6, P<0.05). 3) These substances were applied on the giant neurone, identified subesophageal ganglia of the african giant snail (Achatina fulica Ferussac) by bath-application method and microdropapplication method. As the results of the experiment, it was clarified that l-GABOB inhibited more strongly the electrical activity of the neurone than d-GABOB did it.
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Published Date | 1976-04-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume88
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Issue | issue3-4
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 209
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End Page | 221
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/88/3-4/88_3-4_209/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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