ID | 16388 |
Eprint ID | 16388
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FullText URL | |
Title Alternative | Inhibitory action of 4-amino-3(RS)-hydroxybutanoic acid maleate on pentylenetetrazol, bicuculline and penicillin induced seizure discharges in cats
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Author |
Numoto, Akihiro
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Abstract | Effects of 4-amino-3(RS)-hydroxybutanoic acid maleate [(RS)-GABOB maleate] on threshold of pentylenetetrazol (PTZ) induced convulsion in the rabbit, and PTZ, bicuculline or penicillin induced seizure discharges in cats were examined and found following results; An intravenous (i.v.) injection of (RS)-GABOB maleate increased the threshold of convulsion, and an intracisternal (i.c.) injection of it prolonged latency for onset of spike discharges and decreased frequency and duration of the burst. The i.c. injection of (RS)-GABOB maleate apparently inhibited the both bicuculline and penicillin induced seizure discharges and the i.v. injection slightly depressed them. An injection of (RS)-GABOB maleate into the reticular formation absolutely inhibited the penicillin induced seizure discharges. The inhibitory action of (RS)-GABOB maleate on the penicillin induced abnormal discharges was stronger than that of (R)-GABOB.
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Keywords | 4-Amino-3(RS)-hydroxybutanoic acid maleate
ぺンチレンテトラゾール
ぺニシリン
ビククリン
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Published Date | 1983-10-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume95
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Issue | issue9-10
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 987
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End Page | 1001
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_987/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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