ID | 67585 |
Sort Key | 7
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Title Alternative | A case of immune checkpoint inhibitor-associated colitis treated with infliximab
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Author |
Iwamuro, Masaya
Department of Gastroenterology and Hepatology, Okayama University Hospital
ORCID
Kaken ID
publons
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Hiraoka, Sakiko
Inflammatory Bowel Disease Center, Okayama University Hospital
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publons
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Otsuka, Motoyuki
Department of Gastroenterology and Hepatology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | A 52-year-old Japanese man diagnosed with non-small cell lung cancer initiated chemotherapy with tremelimumab, durvalumab, nanoparticle albumin-bound paclitaxel, and carboplatin. On the fourth day of the first treatment course, he developed a fever, followed by watery diarrhea exceeding 10 episodes per day and bloody stools the next day. Immunotherapy-related adverse event colitis was diagnosed through CT scans and colonoscopy examinations. Despite the ineffectiveness of systemic steroid administration, prompt alleviation of symptoms was achieved through the administration of infliximab. In our case, the patient developed Grade 3 diarrhea, prompting the initiation of intravenous prednisolone at 80mg/day in accordance with guidelines. However, symptom improvement was not attained. In situations where symptoms persist beyond three days despite systemic steroid administration, the consideration of adjunctive infliximab use at a dosage of 5mg/kg becomes necessary.
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Keywords | インフリキシマブ(infliximab)
免疫関連有害事象(immune-related adverse events)
大腸炎(colitis)
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Note | 症例報告 (Case Report)
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Publication Title |
Journal of Okayama Medical Association
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Published Date | 2024-08-01
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Volume | volume136
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Issue | issue2
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 69
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End Page | 73
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Related Url | isVersionOf https://doi.org/10.4044/joma.136.69
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OAI-PMH Set |
岡山大学
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language |
Japanese
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Copyright Holders | Copyright (c) 2024 岡山医学会
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File Version | publisher
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Refereed |
True
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DOI | |
Eprints Journal Name | joma
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