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ID 48275
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Author
Ghosh, Souvik
Gatheru, Zipporah
Nyangao, James
Adachi, Noriaki
Urushibara, Noriko
Kobayashi, Nobumichi
Abstract
We report here the full genomic analysis of a simian SA11-like G3P[2] group A rotavirus (GAR) strain, B10, isolated from an asymptomatic infant in Kenya in 1987. By nucleotide sequence identities and phylogenetic analyses, the VP7–VP4–VP2–VP3–NSP1–NSP2–NSP3–NSP5 genes of strain B10 exhibited maximum genetic relatedness to those of the different isolates of simian strain SA11, and were assigned to the G3–P[2]–C5–M5–A5–N5–T5–H5 genotypes, respectively. On the other hand, the VP1, VP6 and NSP4 genes of strain B10 did not belong to any of the established GAR genotypes, and therefore, were assigned to new genotype numbers R8, I16 and E13, respectively, by the Rotavirus Classification Working Group. These observations suggested that strain B10 might have originated from reassortment event/s involving simian SA11-like strains and GAR strains from unknown animal host species (possibly other wild animals) preceding transmission to humans. Alternatively, considering the lack of data on simian GARs, it might be also possible that the VP1, VP6 and NSP4 genes of strain B10 are those of unknown simian strains, and that strain B10 might be a typical simian strain that was directly transmitted to humans. Therefore, either hypothesis pointed towards a rare instance of possible direct transmission of GARs from an animal host (possibly a monkey or some other wild animal) to humans. This was corroborated by the presence of different species of wild animals including non-human primates, and unhygienic conditions at the sampling site. To our knowledge, the present study is the first report on the detection of a simian SA11-like G3P[2] GAR strain in humans.
Keywords
Group A rotavirus
Novel genotypes
Zoonosis
Simian
Human
Published Date
2011-01
Publication Title
Infection, Genetics and Evolution
Volume
volume11
Issue
issue1
Publisher
Elsevier
Start Page
57
End Page
63
ISSN
1567-1348
NCID
AA11697619
Content Type
Journal Article
Project
Collaborative Research of Okayama University for Infectious Diseases in India
Official Url
http://www.sciencedirect.com/science/article/pii/S1567134810002911
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2010 Elsevier B.V. All rights reserved.
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Refereed
True
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