ID | 66530 |
Author |
Takatsu, Fumiaki
Department of Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio
Department of Thoracic Surgery, Okayama University Hospital
Shien, Kazuhiko
Department of Thoracic Surgery, Okayama University Hospital
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Yamamoto, Hiromasa
Department of Thoracic Surgery, Okayama University Hospital
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Watanabe, Mototsugu
Okayama University Thoracic Surgery Study Group
Hayama, Makio
Okayama University Thoracic Surgery Study Group
Ueno, Tsuyoshi
Okayama University Thoracic Surgery Study Group
Sugimoto, Ryujiro
Okayama University Thoracic Surgery Study Group
Maki, Yuho
Okayama University Thoracic Surgery Study Group
Fujiwara, Toshiya
Okayama University Thoracic Surgery Study Group
Okita, Riki
Okayama University Thoracic Surgery Study Group
Inokawa, Hidetoshi
Okayama University Thoracic Surgery Study Group
Tao, Hiroyuki
Okayama University Thoracic Surgery Study Group
Hirami, Yuji
Okayama University Thoracic Surgery Study Group
Matsuda, Eisuke
Okayama University Thoracic Surgery Study Group
Kataoka, Kazuhiko
Okayama University Thoracic Surgery Study Group
Yamashita, Motohiro
Okayama University Thoracic Surgery Study Group
Sano, Yoshifumi
Okayama University Thoracic Surgery Study Group
Matsuura, Motoki
Okayama University Thoracic Surgery Study Group
Mizutani, Hisao
Okayama University Thoracic Surgery Study Group
Toyooka, Shinichi
Department of Thoracic Surgery, Okayama University Hospital
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Abstract | Background In survivors of head and neck cancer (HNC), second primary lung cancer (SPLC) often develop as a result of a common risk factor, that is, smoking. A multicenter experience was reviewed to evaluate how the history of a diagnosis of HNC affects the outcomes of patients undergoing pulmonary resection for SPLC.
Methods A multicenter retrospective analysis of patients hospitalized between January 2012 and December 2018 was performed. From a cohort of 4521 patients undergoing therapeutic pulmonary resection for primary non-small cell lung cancer, 100 patients with a previous history of HNC (HNC group) were identified. These patients were compared with a control group consisting of 200 patients without an HNC history from the same cohort pair-matched with operating facility, age, sex, and pathologic stage of lung cancer. Results At the time of surgery for SPLC, the HNC group showed malnutrition with a lower prognostic nutritional index compared with the control group (P < .001). The HNC group was determined to have postoperative complications more frequently (P = .02). The 5-year overall survival rates in the HNC and control groups were 59.0% and 83.2%, respectively (P < .001). Statistically, HNC history, lower prognostic nutritional index, squamous cell lung cancer, and TNM stage were identified to be independently associated with poor survival. Conclusions Patients with SPLC after primary HNC often present with malnutrition and are predisposed to postoperative complications and poor survival after pulmonary resection. |
Note | © 2024 by The Society of Thoracic Surgeons. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
This fulltext file will be available in Dec. 2024.
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Published Date | 2024-01
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Publication Title |
The Annals of Thoracic Surgery
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Volume | volume117
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Issue | issue1
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Publisher | Elsevier BV
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Start Page | 181
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End Page | 188
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ISSN | 0003-4975
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NCID | AA00533201
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2024 by The Society of Thoracic Surgeons
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1016/j.athoracsur.2022.04.052
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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