ID | 49253 |
JaLCDOI | |
FullText URL | |
Author |
Furukawa, Masashi
Shien, Kazuhiko
Maki, Yuho
Muraoka, Takayuki
Tanaka, Norimitsu
Ueno, Tsuyoshi
Asano, Hiroaki
Kaken ID
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Abstract | Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p=0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p=0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion.
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Keywords | never-smoker
lung cancer
adenocarcinoma
nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α
epidermal growth factor receptor
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2013-02
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Volume | volume67
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 19
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End Page | 24
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT | |
Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52534
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