| ID | 67293 |
| FullText URL | |
| Author |
Masai, Kaori
Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nakayama, Yuta
Department of Medical Neurobiology, Okayama University Medical School
Shin, Kotaro
Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sugahara, Chiaki
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyazaki, Ikuko
Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Yasuhara, Takao
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Date, Isao
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Asanuma, Masato
Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | Adult neurogenesis in the hippocampus and subventricular zone (SVZ) is impaired by intracerebroventricular administration of streptozotocin (icv-STZ) to rodents. Although neural cells in the several brain regions which connect with the hippocampus or SVZ is thought to be involved in the adult neurogenesis, few studies have investigated morphological alterations of glial cells in these areas. The present study revealed that icv-STZ induces reduction of neural progenitor cells and a dramatic increase in reactive astrocytes and microglia especially in the hippocampus and various hippocampus-connected brain areas. In contrast, there was no significant neuronal damage excluding demyelination of the stria medullaris. The results indicate the hippocampal neurogenesis impairment of this model might be occurred by activated glial cells in the hippocampus, or hippocampus-connected regions.
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| Keywords | Streptozotocin
Adult neurogenesis
Astrocyte
Microglia
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| Note | © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
This fulltext file will be available in Dec. 2024.
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| Published Date | 2024-01-18
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| Publication Title |
Neuroscience Letters
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| Volume | volume820
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| Publisher | Elsevier
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| Start Page | 137598
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| ISSN | 0304-3940
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| NCID | AA00754925
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2023 Elsevier B.V.
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| File Version | author
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| PubMed ID | |
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| Related Url | isVersionOf https://doi.org/10.1016/j.neulet.2023.137598
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| License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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| Funder Name |
Japan Society for the Promotion of Science
Setsurou Fujii Memorial, the Osaka Foundation for Promotion of Fundamental Medical Research
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| 助成番号 | JP19K07993
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