FullText URL fulltext20230828-03.pdf
Author Al‑Hammad, Wlla| Fujikura, Mamiko| Hisatomi, Miki| Okada, Shunsuke| Munhoz, Luciana| Kawazu, Toshiyuki| Takeshita, Yohei| Fujita, Mariko| Yanagi, Yoshinobu| Asaumi, Jun-Ichi|
Keywords vascular anomalies magnetic resonance imaging computed tomography dynamic contrast-enhanced magnetic resonance imaging contrast index curve
Published Date 2023-07-27
Publication Title Oncology Letters
Volume volume26
Issue issue3
Publisher Spandidos Publications
Start Page 394
ISSN 1792-1074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Al-Hammad et al.
File Version publisher
PubMed ID 37600333
DOI 10.3892/ol.2023.13980
Web of Science KeyUT 001049518700001
Related Url isVersionOf https://doi.org/10.3892/ol.2023.13980
JaLCDOI 10.18926/AMO/65492
FullText URL 77_3_273.pdf
Author Shimizu, Yudai| Kuroda, Masahiro| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Yoshida, Suzuka| Fukumura, Yuka| Nakamura, Yoshihide| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| Bamgbose, Babatunde O.| Yanagi, Yoshinobu| Asaumi, Junichi|
Abstract Diffusion kurtosis (DK) imaging (DKI), a type of restricted diffusion-weighted imaging, has been reported to be useful for tumor diagnoses in clinical studies. We developed a software program to simultaneously create DK images with apparent diffusion coefficient (ADC) maps and conducted an initial clinical study. Multi-shot echo-planar diffusion-weighted images were obtained at b-values of 0, 400, and 800 sec/mm2 for simple DKI, and DK images were created simultaneously with the ADC map. The usefulness of the DK image and ADC map was evaluated using a pixel analysis of all pixels and a median analysis of the pixels of each case. Tumor and normal tissues differed significantly in both pixel and median analyses. In the pixel analysis, the area under the curve was 0.64 for the mean kurtosis (MK) value and 0.77 for the ADC value. In the median analysis, the MK value was 0.74, and the ADC value was 0.75. The MK and ADC values correlated moderately in the pixel analysis and strongly in the median analysis. Our simple DKI system created DK images simultaneously with ADC maps, and the obtained MK and ADC values were useful for differentiating head and neck tumors from normal tissue.
Keywords simple diffusion kurtosis imaging mean kurtosis clinical trial head and neck tumor magnetic resonance imaging
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 273
End Page 280
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357628
Web of Science KeyUT 001026279600005
FullText URL isd-49-27.pdf
Author Bamgbose, Babatunde O.| Okada, Shunsuke| Hisatomi, Miki| Yanagi, Yoshinobu| Takeshita, Yohei| Abdu, Zahrau Saleh| Ekuase, Edugie J.| Asaumi, Jun-ichi|
Keywords Tooth Supernumerary Odontoma Odontogenic Cyst
Published Date 2019-05-25
Publication Title Imagining Science in Dentistry
Volume volume49
Issue issue1
Publisher Korean Academy of Oral and Maxillofacial Radiology
Start Page 27
End Page 34
ISSN 22337822
NCID AA12764256
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by Korean Academy of Oral and Maxillofacial Radiology
File Version publisher
PubMed ID 30941285
DOI 10.5624/isd.2019.49.1.27
Web of Science KeyUT 000462925200004
Related Url isVersionOf https://doi.org/10.5624/isd.2019.49.1.27
Author Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi|
Published Date 2009-06
Publication Title 岡山歯学会雑誌
Volume volume28
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/52009
FullText URL 67_6_359.pdf
Author Katashima, Kazunori| Kuroda, Masahiro| Ashida, Masakazu| Sasaki, Takanori| Taguchi, Takehito| Matsuzaki, Hidenobu| Murakami, Jun| Yanagi, Yoshinobu| Hisatomi, Miki| Hara, Marina| Kato, Hirokazu| Ohmura, Yuichi| Kobayashi, Tomoki| Kanazawa, Susumu| Harada, Sosuke| Takemoto, Mitsuhiro| Ohno, Seiichiro| Mimura, Seiichi| Asaumi, Junichi|
Abstract It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30sec. Heating at 42℃ was used to induce apoptosis while heating at 48℃ was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3μm. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30msec might be optimal to distinguish between apoptosis and necrosis.
Keywords ADC apoptosis necrosis hyperthermia cell density
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2013-12
Volume volume67
Issue issue6
Publisher Okayama University Medical School
Start Page 359
End Page 367
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24356720
Web of Science KeyUT 000328915700004
Author Kawakami, Shigehisa| Kodama, Naoki| Maeda, Naoto| Sakamoto, Shunichi| Oki, Kazuhiro| Yanagi, Yoshinobu| Asaumi, Jun-Ichi| Maeda, Teruta| Minagi, Shogo|
Published Date 2012-01-15
Publication Title Journal of Neuroscience Methods
Volume volume203
Issue issue1
Content Type Journal Article
Author Hisatomi, Miki| Yanagi, Yoshinobu| Konouchi, Hironobu| Matsuzaki, Hidenobu| Takenobu, Toshihiko| Unetsubo, Teruhisa| Asaumi, Jun-ichi|
Published Date 2011-02
Publication Title Oral Oncology
Volume volume47
Issue issue2
Content Type Journal Article
Author Yanagi, Yoshinobu| Fujita, Mariko| Hisatomi, Miki| Matsuzaki, Hidenobu| Konouchi, Hironobu| Katase, Naoki| Nagatsuka, Hitoshi| Asaumi, Jun-ichi|
Published Date 201012
Publication Title Oral Radiology
Volume volume26
Issue issue2
Content Type Journal Article
Author Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Shigehara, Hiroshi| Kishi, Kanji|
Published Date 2004-9
Publication Title European Journal of Radiology
Volume volume51
Issue issue3
Content Type Journal Article
Author Asaumi, Jun-ichi| Yanagi, Yoshinobu| Konouchi, Hironobu| Hisatomi, Miki| Matsuzaki, Hidenobu| Kishi, Kanji|
Published Date 2004-7
Publication Title Oral Oncology
Volume volume40
Issue issue6
Content Type Journal Article
Author Maki, Yu| Murakami, Jun| Asaumi, Jun-ichi| Tsujigiwa, Hidetsugu| Nagatsuka, Hitoshi| Kokeguchi, Susumu| Fukui, Kazuhiro| Kawai, Noriko| Yanagi, Yoshinobu| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
Published Date 2005-7
Publication Title Oral Oncology
Volume volume41
Issue issue10
Content Type Journal Article
Author Murakami, Jun| Asaumi, Jun-ichi| Kawai, Noriko| Tsujigiwa, Hidetsugu| Yanagi, Yoshinobu| Nagatsuka, Hitoshi| Inoue, Tetsuyoshi| Kokeguchi, Susumu| Kawasaki, Shoji| Kuroda, Masahiro| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
Published Date 2005-07
Publication Title Cancer Chemotherapy and Pharmacology
Volume volume56
Issue issue1
Content Type Journal Article
Author Murakami, Jun| Asaumi, Jun-ichi| Maki, Yuu| Tsujigiwa, Hidetsugu| Kuroda, Masahiro| Nagai, Noriyuki| Yanagi, Yoshinobu| Inoue, Tetsuyoshi| Kawasaki, Shoji| Tanaka, Noriaki| Matsubara, Nagahide| Kishi, Kanji|
Published Date 2004-2
Publication Title Oral Oncology
Volume volume40
Issue issue6
Content Type Journal Article