このエントリーをはてなブックマークに追加
ID 58029
FullText URL
fulltext.pdf 2.19 MB
Author
Wang, Ning Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Świtalska, Marta Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Wang, Li Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID
Shaban, Elkhabiry Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Hossain, Md Imran Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
El Sayed, Ibrahim El Tantawy Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
Wietrzyk, Joanna Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
Inokuchi, Tsutomu Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
Abstract
Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
Keywords
cryptolepine
neocryptolepine
isocryptolepine
antiproliferative activity
structure activity relationships
Published Date
2019-06-05
Publication Title
Molecures
Volume
volume24
Issue
issue11
Publisher
MDPI
ISSN
1420-3049
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 by the authors.
File Version
publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3390/molecules24112121
License
http://creativecommons.org/licenses/by/4.0/