JaLCDOI 10.18926/AMO/62812
FullText URL 75_6_719.pdf
Author Uehara, Shinya| Fujio, Kei| Yamasaki, Tomoya| Otsuki, Hideo|
Abstract Differentiating patients by age and causative bacterial morphology might aid in making the appropriate choice of antimicrobial agent when treating acute uncomplicated cystitis. In this retrospective analysis, the non-susceptibility rates of the causative bacteria to cefcapene-pivoxil (CFPN-PI) and levofloxacin (LVFX) were determined after dividing patients with acute uncomplicated cystitis by age group (15-54 and 55-74 years old) and by bacterial morphology: gram-positive cocci (GPC) or gram-negative rod (GNR). The overall non-susceptibility rates for CFPN-PI and LVFX were 19.4% and 15.3%, respectively. When the subjects were divided by age, only the non-susceptibility rate for LVFX in the younger group significantly decreased (to 8.7%). When the groups were divided by both age and bacterial morphology, the younger GNR group had non-susceptibility rates of 6.9% to CFPN-PI and 7.8% to LVFX, whereas the younger GPC group showed 10.2% non-susceptibility to LVFX. The older GNR group showed 9.8% non-susceptibility to CFPN-PI, while the older GPC group showed 7.2% non-susceptibility to LVFX. All the non-susceptibility rates were lower than 10.2% in the sub-divided groups. Differentiating patients by age and the morphology of causative bacteria can aid in making the appropriate choice of antimicrobial agent and may improve treatment outcomes in patients with acute uncomplicated cystitis.
Keywords acute uncomplicated cystitis oral antimicrobial agents antimicrobial susceptibility menopause Gram stain
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-12
Volume volume75
Issue issue6
Publisher Okayama University Medical School
Start Page 719
End Page 724
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34955540
Web of Science KeyUT 000735297900008
NAID 120007180280
FullText URL fulltext.pdf
Author Hayami, Hiroshi| Takahashi, Satoshi| Ishikawa, Kiyohito| Yasuda, Mitsuru| Yamamoto, Shingo| Wada, Koichiro| Kobayashi, Kanao| Hamasuna, Ryoichi| Minamitani, Shinichi| Matsumoto, Tetsuya| Kiyota, Hiroshi| Tateda, Kazuhiro| Sato, Junko| Hanaki, Hideaki| Masumori, Naoya| Nishiyama, Hiroyuki| Miyazaki, Jun| Fujimoto, Kiyohide| Tanaka, Kazushi| Uehara, Shinya| Matsubara, Akio| Ito, Kenji| Hayashi, Kenji| Kurimura, Yuichiro| Ito, Shin| Takeuchi, Toshimi| Narita, Harunori| Izumitani, Masanobu| Nishimura, Hirofumi| Kawahara, Motoshi| Hara, Makoto| Hosobe, Takahide| Takashima, Kenji| Chokyu, Hirofumi| Matsumura, Masaru| Ihara, Hideari| Uno, Satoshi| Monden, Koichi| Sumii, Toru| Kawai, Shuichi| Kariya, Satoru| Sato, Takashi| Yoshioka, Masaru| Kadena, Hitoshi| Matsushita, Shinji| Nishi, Shohei| Hosokawa, Yukinari| Shirane, Takeshi| Yoh, Mutsumasa| Watanabe, Syuji| Makinose, Shinichi| Uemura, Tetsuji| Goto, Hirokazu|
Keywords Surveillance Susceptibility Resistance Acute uncomplicated cystitis
Published Date 2019-06
Publication Title Journal of Infection and Chemotherapy
Volume volume25
Issue issue6
Publisher Elsevier
Start Page 413
End Page 422
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.
File Version publisher
PubMed ID 30905628
DOI 10.1016/j.jiac.2019.02.021
Web of Science KeyUT 000466427000002
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2019.02.021
JaLCDOI 10.18926/AMO/48078
FullText URL 66_1_23.pdf
Author Watanabe, Toyohiko| Inoue, Miyabi| Ishii, Ayano| Yamato, Toyoko| Yamamoto, Masumi| Sasaki, Katsumi| Kobayashi, Yasuyuki| Araki, Motoo| Uehara, Shinya| Saika, Takashi| Kumon, Hiromi|
Abstract Polypropylene mesh implants for the correction of pelvic organ prolapse (POP) are now available in Japan. We developed an innovative approach for correcting POP by placing polypropylene mesh transvaginally with laparoscopic assistance. From June 2007 through March 2010, sixteen consecutive patients with symptomatic stage 2 or 3 pelvic organ prolapse underwent the laparoscopic-assisted tension-free vaginal mesh procedure at Okayama University Hospital. All patients were evaluated before and at 1, 3, 6, and 12 months after surgery. Female sexual function was also evaluated with the Female Sexual Function Index (FSFI). The procedure was performed successfully without significant complications. Fifteen of 16 patients were considered anatomically cured (93.8%) at 12 months postoperatively. One patient with a recurrent stage 3 vaginal vault prolapse required sacral colpopexy six months postoperatively. Total FSFI scores improved significantly from 10.3±1.3 at baseline to 18.0±1.2 at 12 months after surgery. The laparoscopic-assisted trans-vaginal mesh is a safe, effective, and simple procedure for POP repairs. The procedure not only restores anatomic relationships but also improves sexual function.
Keywords tension-free vaginal mesh pelvic organ prolapse laparoscopic female urology sexual function
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-02
Volume volume66
Issue issue1
Publisher Okayama University Medical School
Start Page 23
End Page 29
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22358136
Web of Science KeyUT 000300800700004
JaLCDOI 10.18926/AMO/31836
FullText URL fulltext.pdf
Author Wada, Koichiro| Kariyama, Reiko| Mitsuhata, Ritsuko| Uehara, Shinya| Watanabe, Toyohiko| Monden, Koichi| Kumon, Hiromi|
Abstract

Urinary tract infections (UTIs) due to fluoroquinolone-insusceptible Escherichia coli have become increasingly common in recent years. We investigated the potential relationships between clinical measures to combat fluoroquinolone-insusceptible E. coli and experimental analyses on E. coli isolates. Over a 14-year period from 1994 through 2007, a total of 828 E. coli isolates were collected from patients (one isolate per patient) with UTI at the urology ward of Okayama University Hospital. We analyzed the mutations in quinolone resistance-determining regions of DNA gyrase (gyrA) and topoisomerase IV (parC). The production of biofilm by these isolates was also examined and the associated medical records were retrospectively reviewed. Seven of 189 (3.7%) strains from uncomplicated UTIs and 82 of 639 (12.8%) strains from complicated UTIs were insusceptible to fluoroquinolones. Amino acid replacements of type II topoisomerases were frequently observed at positions 83 and 87 in GyrA and at positions 80 and 84 in ParC. No significant difference in the biofilm-forming capabilities was observed between fluoroquinolone-susceptible and -insusceptible E. coli. Our study suggests that biofilm formation of fluoroquinolone-insusceptible E. coli isolates is not a major mechanism of resistance in patients with UTI.

Keywords fluoroquinolone Escherichia coli biofilm MICs QRDRs
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2009-10
Volume volume63
Issue issue5
Publisher Okayama University Medical School
Start Page 263
End Page 272
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
PubMed ID 19893602
Web of Science KeyUT 000271132000006
JaLCDOI 10.18926/AMO/30950
FullText URL fulltext.pdf
Author Saika, Takashi| Kobayashi, Yasuyuki| Watanabe, Toyohiko| Manabe, Daisuke| Ebara, Shin| Uehara, Shinya| Nasu, Yasutomo| Kumon, Hiromi|
Abstract

To evaluate morbidity in Hybrid Radical Prostatectomy (HRP, hybridized laparoscopic and open retropubic radical prostatectomy). The operative and pathological outcomes obtained in 25 consecutive patients who underwent HRP were reviewed. The median operating time was 220min, median blood loss was 550ml, and no patient required an allogenic blood transfusion. No severe postoperative complications were observed. The surgical margin was positive in 12% of all patients, and in 1 patient with pT2 or less (4.5%). These results indicate that HRP is safe and may be able to combine the benefits of both laparoscopic and open procedures.

Keywords prostate cancer radical prostatectomy hybrid surgery morbidity positive surgical margin
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2008-12
Volume volume62
Issue issue6
Publisher Okayama University Medical School
Start Page 379
End Page 384
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
File Version publisher
Refereed True
Web of Science KeyUT 000262025000004
Author Uehara, Shinya|
Published Date 2007-03-23
Publication Title
Content Type Thesis or Dissertation