Tabata, Masahiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Severe Cytokine Release Syndrome and Immune Effector Cell-associated Neurotoxicity Syndrome in a Man Receiving Immune Checkpoint Inhibitors for Lung Cancer

FullText URL	fulltext20240531-01.pdf
Author	Tanaka, Takaaki\| Taoka, Masataka\| Makimoto, Go\| Ninomiya, Kiichiro\| Higo, Hisao\| Fujii, Masanori\| Ichihara, Eiki\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\|
Keywords	immune checkpoint inhibitor nivolumab ipilimumab cytokine release syndrome immune effector cell-associated neurotoxicity syndrome
Published Date	2024-05-01
Publication Title	Internal Medicine
Volume	volume63
Issue	issue9
Publisher	Japanese Society of Internal Medicine
Start Page	1261
End Page	1267
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	37722894
DOI	10.2169/internalmedicine.2429-23
Web of Science KeyUT	001223220900001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.2429-23

Concomitant osimertinib and antituberculosis therapy in an elderly patient with EGFR-mutated lung cancer and pulmonary tuberculosis: A case report

FullText URL	fulltext.pdf
Author	Matsuura, Hiroaki\| Higo, Hisao\| Kuribayashi, Tadahiro\| Tamaoki, Akihiko\| Nakasuka, Takamasa\| Uno, Mari\| Makimoto, Go\| Ninomiya, Kiichiro\| Fujii, Masanori\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Miyahara, Nobuaki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\| Ohashi, Kadoaki\|
Keywords	case report EGFR-mutated lung cancer osimertinib pulmonary tuberculosis rifampicin
Published Date	2024-05-02
Publication Title	Thoracic Cancer
Publisher	Wiley
ISSN	1759-7706
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	38698706
DOI	10.1111/1759-7714.15324
Web of Science KeyUT	001216948400001
Related Url	isVersionOf https://doi.org/10.1111/1759-7714.15324

CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer

FullText URL	fulltext.pdf
Author	Hara, Naofumi\| Ichihara, Eiki\| Kano, Hirohisa\| Ando, Chihiro\| Morita, Ayako\| Nishi, Tatsuya\| Okawa, Sachi\| Nakasuka, Takamasa\| Hirabae, Atsuko\| Abe, Masaya\| Asada, Noboru\| Ninomiya, Kiichiro\| Makimoto, Go\| Fujii, Masanori\| Kubo, Toshio\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	Epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) cell cycle CDK4/6 inhibitor
Published Date	2023-10-31
Publication Title	Translational Lung Cancer Research
Volume	volume12
Issue	issue10
Publisher	AME Publishing Company
ISSN	2218-6751
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Translational Lung Cancer Research.
File Version	publisher
PubMed ID	38025818
DOI	10.21037/tlcr-23-99
Web of Science KeyUT	001091030600001
Related Url	isVersionOf https://doi.org/10.21037/tlcr-23-99

Massive hemoptysis in a post-operative patient with recurrent lung cancer successfully treated by the combination therapy of Endobronchial Watanabe Spigot and bronchial artery embolization

FullText URL	fulltext.pdf
Author	Taoka, Masataka\| Makimoto, Go\| Umakoshi, Noriyuki\| Ninomiya, Kiichiro\| Higo, Hisao\| Kato, Yuka\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	Hemoptysis Bronchial artery embolization Endoscopic bronchial occlusion Endobronchial Watanabe Spigot
Published Date	2022
Publication Title	Respiratory Medicine Case Reports
Volume	volume38
Publisher	Elsevier
Start Page	101669
ISSN	2213-0071
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	35646587
DOI	10.1016/j.rmcr.2022.101669
Web of Science KeyUT	001089212200003
Related Url	isVersionOf https://doi.org/10.1016/j.rmcr.2022.101669

Efficacy of gilteritinib in comparison with alectinib for the treatment of ALK-rearranged non-small cell lung cancer

FullText URL	fulltext.pdf
Author	Ando, Chihiro\| Ichihara, Eiki\| Nishi, Tatsuya\| Morita, Ayako\| Hara, Naofumi\| Takada, Kenji\| Nakasuka, Takamasa\| Watanabe, Hiromi\| Kano, Hirohisa\| Nishii, Kazuya\| Makimoto, Go\| Kondo, Takumi\| Ninomiya, Kiichiro\| Fujii, Masanori\| Kubo, Toshio\| Ohashi, Kadoaki\| Matsuoka, Ken-Ichi\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	alectinib ALK gilteritinib non-small cell lung cancer TKI
Published Date	2023-09-15
Publication Title	Cancer Science
Volume	volume114
Issue	issue11
Publisher	Wiley
Start Page	4343
End Page	4354
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Authors.
File Version	publisher
PubMed ID	37715310
DOI	10.1111/cas.15958
Web of Science KeyUT	001067479000001
Related Url	isVersionOf https://doi.org/10.1111/cas.15958

PD-1 blockade augments CD8+ T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer

FullText URL	fulltext20230421-01.pdf figure20230421-01.pdf
Author	Nakasuka, Takamasa\| Ohashi, Kadoaki\| Nishii, Kazuya\| Hirabae, Atsuko\| Okawa, Sachi\| Tomonobu, Nahoko\| Takada, Kenji\| Ando, Chihiro\| Watanabe, Hiromi\| Makimoto, Go\| Ninomiya, Kiichiro\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Kumon, Hiromi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	EGFR mutation Non-small cell lung cancer Antitumor immunity Non-inflamed tumor Ad-SGE-REIC Gene therapy PD-1
Note	©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.lungcan.2023.01.018.\| This fulltext file will be available in Apr. 2024.\|
Published Date	2023-04
Publication Title	Lung Cancer
Volume	volume178
Publisher	Elsevier BV
Start Page	1
End Page	10
ISSN	0169-5002
NCID	AA10785743
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Elsevier B.V.
File Version	author
PubMed ID	36753780
DOI	10.1016/j.lungcan.2023.01.018
Web of Science KeyUT	000931976300001
Related Url	isVersionOf https://doi.org/10.1016/j.lungcan.2023.01.018

Successful and Prompt Treatment with Tepotinib for Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation Combined with Lung Abscess Formation: A Case Report

FullText URL	fulltext.pdf
Author	Makimoto, Go\| Shimonishi, Atsushi\| Ohashi, Kadoaki\| Ninomiya, Kiichiro\| Higo, Hisao\| Kato, Yuka\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	MET Tepotinib Non-small-cell lung cancer
Published Date	2022
Publication Title	Case Reports In Oncology
Volume	volume15
Issue	issue2
Publisher	Karger
Start Page	494
End Page	498
ISSN	1662-6575
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35702678
DOI	10.1159/000524326
Web of Science KeyUT	000864085100005
Related Url	isVersionOf https://doi.org/10.1159/000524326

Pulmonary Aspergilloma and Allergic Bronchopulmonary Aspergillosis Following the 2018 Heavy Rain Event in Western Japan

FullText URL	fulltext.pdf
Author	Ando, Eri\| Nakasuka, Takamasa\| Kubo, Toshio\| Taniguchi, Akihiko\| Ninomiya, Kiichiro\| Kato, Yuka\| Ichihara, Eiki\| Ohashi, Kadoaki\| Rai, Kammei\| Hotta, Katsuyuki\| Yamane, Masaomi\| Miyahara, Nobuaki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	pulmonary aspergilloma allergic bronchopulmonary aspergillosis disaster
Published Date	2022-02-01
Publication Title	Internal Medicine
Volume	volume61
Issue	issue3
Publisher	JAPAN SOC INTERNAL MEDICINE
Start Page	379
End Page	383
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	34373373
DOI	10.2169/internalmedicine.7124-21
Web of Science KeyUT	000752787300015
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.7124-21

Dramatic Response to Carboplatin Plus Paclitaxel in Pancreatic Mucinous Cystadenocarcinoma with Liver Metastasis

FullText URL	fulltext.pdf
Author	Oda, Naohiro\| Tabata, Masahiro\| Uno, Masatoshi\| Umeda, Yuzo\| Kato, Hironari\| Kubo, Toshio\| Senoo, Satoru\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	pancreas mucinous cystadenocarcinoma carboplatin paclitaxel
Published Date	2021-09-15
Publication Title	Internal Medicine
Volume	volume60
Issue	issue18
Publisher	The Japanese Society of Internal Medicine
Start Page	2967
End Page	2971
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	33814494
DOI	10.2169/internalmedicine.6730-20
Web of Science KeyUT	000697279400013
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.6730-20

Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease

FullText URL	fulltext.pdf
Author	Okawa, Sachi\| Rai, Kammei\| Fujii, Nobuharu\| Gion, Yuka\| Ninomiya, Kiichiro\| Kato, Yuka\| Taniguchi, Akihiko\| Kubo, Toshio\| Ichihara, Eiki\| Ohashi, Kadoaki\| Miyahara, Nobuaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	EGFR IgG4-related disease marginal zone lymphoma osimertinib
Published Date	2021-09-01
Publication Title	Internal Medicine
Volume	volume60
Issue	issue17
Publisher	The Japanese Society of Internal Medicine
Start Page	2831
End Page	2837
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	33775999
DOI	10.2169/internalmedicine.6470-20
Web of Science KeyUT	000695856000020
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.6470-20

Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR‑mutant lung cancer with HIF‑1α/TGF‑α expression

FullText URL	fulltext20210810-3.pdf
Author	Nishii, Kazuya\| Ohashi, Kadoaki\| Watanabe, Hiromi\| Makimoto, Go\| Nakasuka, Takamasa\| Higo, Hisao\| Ninomiya, Kiichiro\| Kato, Yuka\| Kubo, Toshio\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	epidermal growth factor receptor osimertinib bevacizumab cetuximab hypoxia‑inducible factor‑1α transforming growth factor‑α
Published Date	2021-7-7
Publication Title	Oncology Letters
Volume	volume22
Issue	issue3
Publisher	Spandidos Publications
Start Page	639
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Nishii et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
File Version	publisher
DOI	10.3892/ol.2021.12900
Web of Science KeyUT	000678494600001
Related Url	isVersionOf https://doi.org/10.3892/ol.2021.12900

VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene-driven non-small-cell lung cancers

FullText URL	fulltext.pdf
Author	Watanabe, Hiromi\| Ichihara, Eiki\| Kayatani, Hiroe\| Makimoto, Go\| Ninomiya, Kiichiro\| Nishii, Kazuya\| Higo, Hisao\| Ando, Chihiro\| Okawa, Sachi\| Nakasuka, Takamasa\| Kano, Hirohisa\| Hara, Naofumi\| Hirabae, Atsuko\| Kato, Yuka\| Ninomiya, Takashi\| Kubo, Toshio\| Rai, Kammei\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Published Date	2021-01-07
Publication Title	Cancer science
Publisher	Wiley
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	33410241
NAID	120007008532
DOI	10.1111/cas.14801
Web of Science KeyUT	000630136900001
Related Url	isVersionOf https://doi.org/10.1111/cas.14801

Demand for weekend outpatient chemotherapy among patients with cancer in Japan

FullText URL	fulltext.pdf
Author	Katayama, Hideki\| Tabata, Masahiro\| Kubo, Toshio\| Kiura, Katsuyuki\| Matsuoka, Junji\| Maeda, Yoshinobu\|
Keywords	Weekend chemotherapy Outpatient Social burden Cancer patient
Published Date	2020-07-04
Publication Title	Supportive Care in Cancer
Volume	volume29
Publisher	Springer
Start Page	1287
End Page	1297
ISSN	0941-4355
NCID	AA10996793
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	publisher
PubMed ID	32621265
DOI	10.1007/s00520-020-05575-x
Web of Science KeyUT	000545922600001
Related Url	isVersionOf https://doi.org/10.1007/s00520-020-05575-x

Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction

FullText URL	fulltext.pdf
Author	Nishii, Kazuya\| Ohashi, Kadoaki\| Tamura, Tomoki\| Ninomiya, Kiichiro\| Matsubara, Takehiro\| Senoo, Satoru\| Kano, Hirohisa\| Watanabe, Hiromi\| Oda, Naohiro\| Makimoto, Go\| Higo, Hisao\| Kato, Yuka\| Ninomiya, Takashi\| Kubo, Toshio\| Yamamoto, Hiromasa \| Tomida, Shuta\| Hotta, Katsuyuki\| Tabata, Masahiro\| Toyooka, Shinichi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs
Published Date	2020-12
Publication Title	Oncology Letters
Volume	volume20
Issue	issue6
Publisher	Spandidos Publications
Start Page	393
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	publisher
PubMed ID	33193853
DOI	10.3892/ol.2020.12256
Web of Science KeyUT	000595649300005
Related Url	isVersionOf https://doi.org/10.3892/ol.2020.12256

集学的治療により長期生存が得られた食道神経内分泌癌の2 例

Author	Gotoda, Tatsuhiro\| Kawano, Seiji\| Kono, Yoshiyasu\| Miura, Kou\| Kanzaki, Hiromitsu\| Iwamuro, Masaya\| Kawahara, Yoshiro\| Tanaka, Takehiro\| Yoshino, Tadashi\| Shirakawad, Yasuhiro\| Tabata, Masahiro\| Tanimoto, Mitsune\| Okada, Hiroyuki\|
Published Date	2016-12-01
Publication Title	Journal of Okayama Medical Association
Volume	volume128
Issue	issue3
Content Type	Journal Article

A Phase I Trial of 100mg/m2 Docetaxel in Patients with Advanced or Recurrent Breast Cancer

JaLCDOI	10.18926/AMO/54607
FullText URL	70_5_425.pdf
Author	Tamura, Tomoki\| Hirata, Taizo\| Tabata, Masahiro\| Hinotsu, Shiro\| Hamada, Akinobu\| Motoki, Takayuki\| Iwamoto, Takayuki\| Mizoo, Taeko\| Nogami, Tomohiro\| Shien, Tadahiko\| Taira, Naruto\| Matsuoka, Junji\| Doihara, Hiroyoshi\|
Abstract	Docetaxel is a standard treatment for patients with advanced or recurrent breast cancer. The recommended dose is 60 to 100 mg/m2. Previous study have shown that the tumor response rates of patients who received docetaxel monotherapy at doses of 60, 75, and 100 mg/m2 were 22.1% , 23.3% , and 36.0% , respectively, and there was a significant relationship between the dose and response. In Europe and the United States, docetaxel is approved at a dose of 100 mg/m2, and Japanese guidelines also recommend a dose of 100 mg/m2. However, the approved dose in Japan is up to 75 mg/m2. We have launched a phase I trial evaluating 100 mg/m2 docetaxel in patients with advanced or relapsed breast cancer. The major eligibility criteria are as follows: age ≥20 years, pathologically diagnosed breast cancer, recurrent or advanced breast cancer, a good performance status, and HER2 [human epidermal growth factor receptor 2] negative. The primary endpoint is demonstrated safety of 100 mg/m2 docetaxel. This study will clarify whether 100mg/m2 docetaxel can be administrated safely in Japanese patients with advanced or recurrent breast cancer.
Keywords	breast cancer phase I trial docetaxel
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-10
Volume	volume70
Issue	issue5
Publisher	Okayama University Medical School
Start Page	425
End Page	427
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27777441
Web of Science KeyUT	000388098700018

HER2異常等の低頻度の分子異常を有する非小細胞肺癌の臨床病理学的特徴を明らかにするための前向き観察研究（HER2-CS Study）と標準化学療法後再発・増悪または標準化学療法不応性のHER2陽性非小細胞肺癌患者を対象としたトラスツズマブエムタンシン（遺伝子組換え）の第2相試験

Title Alternative	A prospective cohort study to define the clinical and pathological features of lung cancers harboring HER2 gene aberrations (the HER2-CS Study) and a phase II study of trastuzumab emtansine (recombinant) in patients with HER2-positive non-small cell lung cancer who recurred, progressed after standard chemotherapy, or were primarily refractory to standard chemotherapy
FullText URL	127_127.pdf
Author	Kiura, Katsuyuki\| Hotta, Katsuyuki\| Sato, Akiko\| Ohashi, Kadoaki\| Ninomiya, Takashi\| Minnami, Daisuke\| Tabata, Masahiro\| Kubo, Toshio\| Kato, Yuka\| Hirata, Taizo\|
Keywords	臨床研究中核病院国立研究開発法人日本医療研究開発機構文部科学省橋渡し研究加速ネットワークプログラム HER2-CS study trastuzumab emtansine
Publication Title	岡山医学会雑誌
Published Date	2015-08-03
Volume	volume127
Issue	issue2
Start Page	127
End Page	132
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.127.127
language	Japanese
Copyright Holders	Copyright (c) 2015 岡山医学会
File Version	publisher
DOI	10.4044/joma.127.127
NAID	130005096256

Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer

Author	Ochi, Nobuaki\| Takigawa, Nagio\| Harada, Daijiro\| Yasugi, Masayuki\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Tanimoto, Mitsune\| Kiura, Katsuyuki\|
Published Date	2014-03-10
Publication Title	Experimental Cell Research
Volume	volume322
Issue	issue1
Content Type	Journal Article

A phase II study of amrubicin and topotecan combination therapy in patients with relapsed or extensive-disease small-cell lung cancer: Okayama Lung Cancer Study Group Trial 0401

Author	Nogami, Naoyuki\| Hotta, Katsuyuki\| Kuyama, Shoichi\| Kiura, Katsuyuki\| Takigawa, Nagio\| Chikamori, Kenichi\| Shibayama, Takuo\| Kishino, Daizo\| Hosokawa, Shinobu\| Tamaoki, Akihiko\| Harita, Shingo\| Tabata, Masahiro\| Ueoka, Hiroshi\| Shinkai, Tetsu\| Tanimoto, Mitsune\|
Published Date	2011-10
Publication Title	Lung Cancer
Volume	volume74
Issue	issue1
Content Type	Journal Article

Triplet Chemotherapy with Cisplatin, Docetaxel, and Irinotecan for Patients with Recurrent or Refractory Non-small Cell Lung Cancer

JaLCDOI	10.18926/AMO/32866
FullText URL	fulltext.pdf
Author	Fujimoto, Nobukazu\| Kiura, Katsuyuki\| Takigawa, Nagio\| Fujiwara, Yoshiro\| Toyooka, Shinichi\| Umemura, Shigeki\| Tabata, Masahiro\| Ueoka, Hiroshi\| Tanimoto, Mitsune\|
Abstract	We examined the feasibility of triplet chemotherapy using cisplatin, docetaxel, and irinotecan for patients with recurrent or refractory non-small cell lung cancer (NSCLC), retrospectively. Twenty-five patients (21 men and 4 women) with NSCLC and good performance status who were <70 years old were analyzed. The median age was 58 years. Most patients had performance status 1 (16/25), stage IV disease (18/25) and adenocarcinoma-histology (16/25). Cisplatin and docetaxel were given on day 1 and irinotecan on day 2;the cycle was repeated every 3 weeks. The objective response rate was 39.1% (95% confidence interval:18.7-59.5%). The median survival time and actual 2-, 3-, and 5-year survival rates were 14.3 months, 32%, 20%, and 8%, respectively. Of note, only 6 patients were treated with gefitinib at the recurrence after triplet chemotherapy;of these, 4 (67%) achieved a partial response, which might result in favorable survival. Grade 3/4 toxicities consisted of neutropenia (100%), neutropenic fever (56%), nausea/vomiting (40%), and diarrhea (16%);no cases of treatment-related death occurred. Triplet chemotherapy showed impressive survival data in our clinical trial, but proved too toxic for use in treating patients with NSCLC in the clinical practice.
Keywords	cisplatin docetaxel irinotecan triplet chemotherapy gefitinib
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2010-02
Volume	volume64
Issue	issue1
Publisher	Okayama University Medical School
Start Page	33
End Page	37
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
File Version	publisher
Refereed	True
PubMed ID	20200582
Web of Science KeyUT	000274868300005