ID | 62326 |
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Author |
Takabatake, Kiyofumi
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Nakano, Keisuke
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Kawai, Hotaka
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Yoshida, Saori
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Omori, Haruka
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Oo, May Wathone
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
Qiusheng, Shan
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Uchida, Kenichiro
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine
Mishima, Katsuaki
Department of Oral and Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine
Nagatsuka, Hitoshi
Department of Oral Pathology and Medicine Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Abstract | Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.
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Keywords | secretory carcinoma
high-grade transformation
ETV6-NTRK3 fusion
cervical lymph node metastasis
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Published Date | 2020-03-25
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Publication Title |
reports
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Volume | volume3
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Issue | issue2
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Publisher | MDPI
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Start Page | 6
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ISSN | 2571-841X
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © 2020 by the authors.
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File Version | publisher
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DOI | |
Web of Science KeyUT | |
Related Url | isVersionOf https://doi.org/10.3390/reports3020006
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License | http://creativecommons.org/licenses/by/4.0/
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