X線照射によるラット臓器中のメタロチオネインの変動について

(1)ラット肝Metallothioneinが増加する2000rad, 72時間後にMTの増加が認められるのは,腎臓のみで他の臓器(心臓,肺,脾臓,赤血球,血漿)では認められなかった.(2)肝,腎臓のMTの照射線量に対する増加には差が認められなかった.(3)照射後の経時的変化では,肝臓が6時間からその増加が認められるのに対して,腎臓では, 24時間と大きな違いが認められた.(4)照射後の血清亜鉛量に低下傾向は,認められないが, Sephacryl S-300のゲル濾過の結果では, Albumin分画の亜鉛量に低下傾向が認められ,血清亜鉛に質的変化が生じていることが示唆された.

The amount of metallothionein in rat liver and kidney was increased 72hr after irradiation by a high dose of X-irradiation (2,000 rad), but in other tissues the amount of metallothionein was not increased. An increase in metallothionein contents in rat liver and kidney was induced 72hr after irradiation when rats were exposed to a single dose between 1,500 and 3,000 rad. Below a single 1,000-rad dose, the increase in metallothionein content was not observed. An increase in the metallothionein content in the liver was observed 6hr after irradiation (2,000 rad). In kidney, the increase in the metallothionein content was observed 24hr after irradiation. Although the zinc content in serum did not change significantly after irradiation (2,000 rad), the zinc content of the albumin fraction decreased slightly.