このエントリーをはてなブックマークに追加
ID 63010
FullText URL
fulltext.pdf 2.66 MB
Author
Tsuge, Mitsuru Department of Pediatric Acute Diseases, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID researchmap
Ikeda, Masanori Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID publons researchmap
Matsumoto, Naomi Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences
Yorifuji, Takashi Department of Epidemiology, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Tsukahara, Hirokazu Department of Pediatrics, Okayama University Academic Field of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID publons researchmap
Abstract
The incidence of allergic diseases is increasing, and research on their epidemiology, pathophysiology, and the prevention of onset is urgently needed. The onset of allergic disease begins in infancy with atopic dermatitis and food allergy and develops into allergic asthma and allergic rhinitis in childhood; the process is defined as "atopic march ". Atopic march is caused by multiple immunological pathways, including allergen exposure, environmental pollutants, skin barrier dysfunction, type 2 inflammation, and oxidative stress, which promote the progression of atopic march. Using recent evidence, herein, we explain the involvement of allergic inflammatory conditions and oxidative stress in the process of atopic march, its epidemiology, and methods for prevention of onset.
Keywords
atopic march
atopic dermatitis
food allergy
allergic asthma
allergic rhinitis
skin barrier dysfunction
alarmin
group 2 innate lymphoid cells
type 2 inflammation
oxidative stress
specific biomarker
epidemiology
phenotype
early intervention
emollient
Published Date
2021-11-19
Publication Title
Children-Basel
Volume
volume8
Issue
issue11
Publisher
MDPI
Start Page
1067
ISSN
2227-9067
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
Copyright Holders
© 2021 by the authors.
File Version
publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.3390/children8111067
License
https://creativecommons.org/licenses/by/4.0/