ID | 58270 |
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Author |
Fukuhara, Ryuichiro
Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Shinya, Takayoshi
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
ORCID
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Fukuma, Shogo
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Ogawa, Nanako
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Masaoka, Yoshihisa
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Tanaka, Takehiro
Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital
ORCID
Kaken ID
publons
Marunaka, Hidenori
Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital
Arioka, Tadashi
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Hiraki, Takao
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
Kaken ID
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Kaji, Mitsumasa
Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital
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Abstract | The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.
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Keywords | 18F-fluorodeoxyglucose positron emission tomography/computed tomography
extranodular spread
metastasis
oral squamous cell carcinoma
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2020-04
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Volume | volume74
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Issue | issue2
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Publisher | Okayama University Medical School
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Start Page | 123
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End Page | 128
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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