ID | 57940 |
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Author |
Ikeda, Tomoka
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Gion, Yuka
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Yoshino, Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Sato, Yasuharu
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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Abstract | Epstein-Barr virus (EBV)-positive mucocutaneous ulcers (EBVMCUs) were first described as a lymphoproliferative disorder in 2010. Clinically, EBVMCUs are shallow, sharply circumscribed, unifocal mucosal or cutaneous ulcers that occur in immunosuppressed patients, including those with advanced age-associated immunosenescence, iatrogenic immunosuppression, primary immune disorders, and HIV/AIDS-associated immune deficiencies. In general, patients exhibit indolent disease progression and spontaneous regression. Histologically, EBVMCUs are characterized by the proliferation of EBV-positive, variable-sized, atypical B-cells. According to conventional histopathologic criteria, EBVMCUs may diagnosed as lymphomas. However, EBVMCUs are recognized as pseudomalignant lesions because they spontaneously regress without anti-cancer treatment. Therefore, overtreatment must be carefully avoided and multilateral differentiation is important. In this article, we reviewed previously reported EBVMCUs focusing on their clinical and pathological aspects in comparison with other EBV-positive B-cell neoplasms.
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Keywords | EBV-positive mucocutaneous ulcer
clinical features
immunosuppression
pathological features
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Published Date | 2019-06-28
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Publication Title |
Journal of Clinical and Experimental Hematopathology
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Volume | volume59
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Issue | issue2
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Publisher | Japanese Society for Lymphoratic Tissue Research
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Start Page | 64
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End Page | 6471
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ISSN | 1346-4280
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NCID | AA11556796
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | Copyright © 2019 The Japanese Society for Lymphoreticular Tissue Research
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File Version | publisher
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Related Url | isVersionOf https://doi.org/10.3960/jslrt.18039
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License | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Citation | Tomoka Ikeda, Yuka Gion, Tadashi Yoshino, Yasuharu Sato, A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects, Journal of Clinical and Experimental Hematopathology, 2019, Volume 59, Issue 2, Pages 64-71, Released June 28, 2019, Online ISSN 1880-9952, Print ISSN 1346-4280, https://doi.org/10.3960/jslrt.18039
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