ID | 30766 |
JaLCDOI | |
FullText URL | |
Author |
Iwagaki, Hiromi
Hizuta, Akio
Uomoto, Masashi
Takeuchi, Yoshiaki
Tanaka, Noriaki
|
Abstract | Plasma 5-hydroxytryptamine (serotonin), tryptophan, neopterin and cortisol levels were measured in patients with depressive cancer cachexia and in healthy controls during the same time period. Patients with advanced cancers had significantly raised neopterin, a marker of endogenous gamma-interferon (IFN-γ) production, and cortisol values, but decreased serotonin and tryptophan levels. Much work has been done to elucidate the possible role of serotonin in depressive states. IFN-γ induces a high level of indoleamine dioxygenase (IDO), a tryptophan degrading enzyme, and high cortisol levels induce high tryptophan oxygenase activity, which in turn increases metabolism along the tryptophannicotinic acid pathway. These results suggest that persistent immune activation and intense adrenal activity occur in patients with cancer cachexia, resulting in disorders involving tryptophan metabolism followed by depression in cancer cahexia. |
Keywords | cancer cachexia
neuro-endocrine-immune interactio
serotonin
neopterin
cortisol
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Amo Type | Article
|
Publication Title |
Acta Medica Okayama
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Published Date | 1997-08
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Volume | volume51
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 233
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End Page | 236
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |