ID | 52429 |
JaLCDOI | |
Title Alternative | Proton Magnetic Resonance Spectroscopy in Patients with Migration Disorders
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FullText URL | |
Author |
Asano, Takashi
Oka, Eiji
Kawahara, Michiko
Sakae, Katsumi
Hiraki, Norio
Ohtahara, Shunsuke
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Abstract | Proton Magnetic Resonance Spectroscopy (1H-MRS) can be used to detect cerebral metabolites including N-acetylaspartate (NAA),creatine (Cr) and choline (Ch). Hence,clinical applications of this method for neuropediatric diseases can be expected. However,regarding neuronal migration disorders,there have been only a few reported studies. We therefore examined the lH-MRS in six patients with migration disorders,ages ranged
from 8months to 28years 10months with a mean of 10years 10months. Investigation was performed using Magnetom H15 (Siemens) with a repetition time of 1500 msec and an echo time of 270msec. The ratio of NAA/Cr,Ch/Cr were examined. The volume of interest with the size of 2 × 2 × 2 ~ 3 × 3 × 5cm3 was chosen in the area including lesions,and a contralateral area without lesions was also investigated. Results were as follows. 1) The ratio of NAA/Cr was low in the area with lesions in all 6cases; 1.41,1.95,2.27 and 1.71 in cases with heterotopic gray matter,0.99 in one case with polymicrogyria,an d 1.30 in one
case with hemimegalencephaly,contrasted with a contralataral area without lesions: 1.89,
2.89,2.87,2.55,3.26,2.03,respectively. 2) The ratio of Ch/Cr showed no consistent difference
between the area including lesions and contralataral area without lesions. Our
findings of a decreased NAA/Cr ratio can be inferred to reflect the decreased numbers of
neuronal cell population,or reduced metabolism in the lesions.
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Keywords | MR spectroscopy
migration disorder
heterotopic gray matter
polymicrogyria
hemimegalencephaly
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Publication Title |
岡山大学教育学部研究集録
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Published Date | 1999
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Volume | volume110
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Issue | issue1
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Publisher | 岡山大学教育学部
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Publisher Alternative | Faculty of Education, Okayama University
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Start Page | 29
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End Page | 34
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ISSN | 0471-4008
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NCID | AN00032875
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Content Type |
Departmental Bulletin Paper
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OAI-PMH Set |
岡山大学
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language |
Japanese
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File Version | publisher
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NAID | |
Eprints Journal Name | bgeou
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