Alternative to Rituximab Therapy for a Patient with Ankylosing Spondylitis Who Was Unable to Continue Anti-TNF Therapy

Katsuyama, Eri; Wakabayashi, Hiroshi; Sada, Ken-ei; Hiramatsu, Sumie; Miyawaki, Yoshia; Morishita, Michiko; Ohashi, Keiji; Watanabe, Haruki; Katsuyama, Takayuki; Zeggar, Sonia; Narazaki, Mariko; Tatebe, Noriko; Watanabe, Katsue S.; Kawabata, Tomoko; Wada, Jun

ID	55444
JaLCDOI	10.18926/AMO/55444
FullText URL	71_5_445.pdf 2.83 MB
Author	Katsuyama, Eri Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Wakabayashi, Hiroshi Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama Municipal Hospital, Sada, Ken-ei Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap Hiramatsu, Sumie Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Miyawaki, Yoshia Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Morishita, Michiko Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Ohashi, Keiji Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Watanabe, Haruki Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Katsuyama, Takayuki Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Zeggar, Sonia Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Narazaki, Mariko Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Tatebe, Noriko Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Watanabe, Katsue S. Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kawabata, Tomoko Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID Wada, Jun Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Abstract	We herein present a case of a 38-year-old man who had bamboo spine and severe sacroiliitis and who was diagnosed with ankylosing spondylitis (AS). Infliximab (IFX) markedly improved the axial symptom but was discontinued due to the side effect of peripheral neuropathy. Switching from IFX to etanercept worsened the side effect. Rituximab (RTX) administration elicited a good response without side effects. RTX might be a suitable option for AS therapy when TNF inhibitors are difficult to use.
Keywords	ankylosing spondylitis rituximab treatment
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2017-10
Volume	volume71
Issue	issue5
Publisher	Okayama University Medical School
Start Page	445
End Page	448
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2017 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	29042704