ID | 62379 |
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Sun, Jingkai
Department of Urology, Zhujiang Hospital, Southern Medical University
Lin, Wenfeng
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wang, Qixu
Department of Urology, Zhujiang Hospital, Southern Medical University
Sakai, Akiko
Department of Molecular Genetics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Xue, Ruizhi
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Watanabe, Masami
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Liu, Chunxiao
Department of Urology, Zhujiang Hospital, Southern Medical University
Sadahira, Takuya
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nasu, Yasutomo
Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Xu, Abai
Department of Urology, Zhujiang Hospital, Southern Medical University
Huang, Peng
Department of Urology, Zhujiang Hospital, Southern Medical University
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Abstract | Human RAD17, as an agonist of checkpoint signaling, plays an essential role in mediating DNA damage. This hospital-based case-control study aimed to explore the association between RAD17 rs1045051, a missense sin-gle nucleotide polymorphism (SNP), and prostate cancer risk. Subjects were 358 prostate cancer patients and 314 cancer-free urology patients undergoing treatment at the Zhujiang Hospital of Southern Medical University in China. RAD17 gene polymorphism rs1045051 was evaluated by the SNaPshot method. Compared with the RAD17 gene polymorphism rs1045051 AA genotype, there was a higher risk of prostate cancer for the CC gen-otype (adjusted odds ratio [AOR] = 1.731, 95% confidence interval [95%CI] = 1.031−2.908, p = 0.038). Compared with the A allele, the C allele was significantly associated with the disease status (AOR = 1.302, 95%CI = 1.037−1.634, p = 0.023). All these findings indicate that in the SNP rs1045051, both the CC genotype and C allele may have a substantial influence on the prostate cancer risk.
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Keywords | prostate cancer
single-nucleotide polymorphisms
cell cycle checkpoint
rs1045051
RAD17
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2021-08
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Volume | volume75
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Issue | issue4
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Publisher | Okayama University Medical School
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Start Page | 415
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End Page | 421
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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