Shien, Kazuhiko - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Robotic Mediastinal Tumor Resections: Position and Port Placement

FullText URL	fulltext.pdf
Author	Okazaki, Mikio\| Shien, Kazuhiko\| Suzawa, Ken\| Sugimoto, Seiichiro\| Toyooka, Shinichi\|
Keywords	robot robot-assisted thoracic surgery mediastinal tumor thymectomy port placement
Published Date	2022-07-22
Publication Title	Journal Of Personalized Medicine
Volume	volume12
Issue	issue8
Publisher	MDPI
Start Page	1195
ISSN	2075-4426
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the authors.
File Version	publisher
PubMed ID	35893289
DOI	10.3390/jpm12081195
Web of Science KeyUT	000845682400001
Related Url	isVersionOf https://doi.org/10.3390/jpm12081195

Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer-associated fibroblast

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Author	Ochi, Kosuke\| Suzawa, Ken\| Thu, Yin Min\| Takatsu, Fumiaki\| Tsudaka, Shimpei\| Zhu, Yidan\| Nakata, Kentaro\| Takeda, Tatsuaki\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Shien, Tadahiko\| Okamoto, Yoshiharu\| Tomida, Shuta\| Toyooka, Shinichi\|
Keywords	cancer-associated fibroblast drug resistance tranilast
Published Date	2022-07-24
Publication Title	Cancer Science
Volume	volume2022
Publisher	Wiley
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	35871750
DOI	10.1111/cas.15502
Web of Science KeyUT	000840374000001
Related Url	isVersionOf https://doi.org/10.1111/cas.15502

One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study

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Author	Namba, Kei\| Suzawa, Ken\| Shien, Kazuhiko\| Miura, Akihiro\| Takahashi, Yuta\| Miyauchi, Shunsaku\| Araki, Kota\| Nakata, Kentaro\| Tomida, Shuta\| Tanaka, Shin\| Miyoshi, Kentaroh\| Otani, Shinji\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Soh, Junichi\| Yamane, Masaomi\| Toyooka, Shinichi\|
Published Date	2022-05-04
Publication Title	Scientific Reports
Volume	volume12
Issue	issue1
Publisher	Nature Portfolio
Start Page	7297
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022
File Version	publisher
PubMed ID	35508484
DOI	10.1038/s41598-022-11064-4
Web of Science KeyUT	000790941900040
Related Url	isVersionOf https://doi.org/10.1038/s41598-022-11064-4

Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma

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Author	Takatsu, Fumiaki\| Yamamoto, Hiromasa\| Tomioka, Yasuaki\| Tanaka, Shin\| Shien, Kazuhiko\| Suzawa, Ken\| Miyoshi, Kentaroh\| Otani, Shinji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Takahashi, Katsuhito\| Toyooka, Shinichi\|
Keywords	Retroperitoneal sarcoma Lung metastasis Metastasectomy
Published Date	2022-04-08
Publication Title	World Journal Of Surgical Oncology
Volume	volume20
Issue	issue1
Publisher	BMC
Start Page	114
ISSN	1477-7819
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35395855
DOI	10.1186/s12957-022-02552-y
Web of Science KeyUT	000780301100001
Related Url	isVersionOf https://doi.org/10.1186/s12957-022-02552-y

YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development

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Author	Fujihara, Miwa\| Shien, Tadahiko\| Shien, Kazuhiko\| Suzawa, Ken\| Takeda, Tatsuaki\| Zhu, Yidan\| Mamori, Tomoka\| Otani, Yusuke\| Yoshioka, Ryo\| Uno, Maya\| Suzuki, Yoko\| Abe, Yuko\| Hatono, Minami\| Tsukioki, Takahiro\| Takahashi, Yuko\| Kochi, Mariko\| Iwamoto, Takayuki\| Taira, Naruto\| Doihara, Hiroyoshi\| Toyooka, Shinichi\|
Keywords	breast cancer YES1 T-DM1 dasatinib drug resistance
Published Date	2021-11-26
Publication Title	International Journal Of Molecular Sciences
Volume	volume22
Issue	issue23
Publisher	MDPI
Start Page	12809
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34884609
DOI	10.3390/ijms222312809
Web of Science KeyUT	000735641400001
Related Url	isVersionOf https://doi.org/10.3390/ijms222312809

Robot-assisted thoracoscopic lobectomy for severe incomplete interlober fissure

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Author	Okazaki, Mikio\| Suzawa, Ken\| Shien, Kazuhiko\| Miyoshi, Kentaroh\| Otani, Shinji\| Yamamoto, Hiromasa\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Toyooka, Shinichi\|
Published Date	2021-08-14
Publication Title	Journal Of Surgical Case Reports
Volume	volume2021
Issue	issue8
Publisher	Oxford Univ Press
Start Page	rjab336
ISSN	2042-8812
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021.
File Version	publisher
PubMed ID	34408837
DOI	10.1093/jscr/rjab336
Web of Science KeyUT	000732056400014
Related Url	isVersionOf https://doi.org/10.1093/jscr/rjab336

Covalent N-arylation by the pollutant 1,2-naphthoquinone activates the EGF receptor

FullText URL	fulltext20210530_3.pdf
Author	Nakahara, Kengo\| Hamada, Kyohei\| Tsuchida, Tomoki\| Takasugi, Nobumasa\| Abiko, Yumi\| Shien, Kazuhiko\| Toyooka, Shinichi\| Kumagai, Yoshito\| Uehara, Takashi\|
Keywords	epidermal growth factor receptor cell signaling chemical modification signal transduction apoptosis
Published Date	2021-12-31
Publication Title	Journal of Biological Chemistry
Volume	volume296
Publisher	Elsevier
Start Page	100524
ISSN	00219258
NCID	AA00251083
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	33705793
DOI	10.1016/j.jbc.2021.100524
Related Url	isVersionOf https://doi.org/10.1016/j.jbc.2021.100524

A Giant Thymic Cyst Accompanied by Acute Mediastinitis

JaLCDOI	10.18926/AMO/60804
FullText URL	74_5_431.pdf
Author	Miura, Akihiro\| Shien, Kazuhiko\| Toji, Tomohiro\| Otani, Shinji\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Soh, Junichi\| Yamane, Masaomi\| Toyooka, Shinichi\|
Abstract	We encountered a rare case of thymic cyst accompanied by mediastinitis. A 39-year-old Japanese male presented with fever and chest pain. The chest CT revealed a mass composed of a lobular cystic lesion with inflammation, suggesting the onset of mediastinitis. A definitive histological diagnosis was not obtained, and we performed a thymectomy. Pathologically, the thymic cyst was accompanied by multiple cavities, mimicking thymic cysts, caused by the inflammatory abscess. The surrounding adipose tissue showed inflammatory cell infiltrations with chronic fibrosis. These findings indicate that clinicians should be aware that thymic cysts may cause severe mediastinitis.
Keywords	thymic cyst multilocular thymic cyst mediastinitis
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2020-10
Volume	volume74
Issue	issue5
Publisher	Okayama University Medical School
Start Page	431
End Page	433
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33106700
Web of Science KeyUT	000581970100009
NAID	120006892930

Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer

FullText URL	fulltext.pdf figure1.tif figure2.tif figure3.tif spfigure1.tif spfigure2.tif SupTable1.xlsx
Author	Ochi, Kosuke\| Suzawa, Ken\| Tomida, Shuta\| Shien, Kazuhiko\| Takano, Jui\| Miyauchi, Shunsaku\| Takeda, Tatsuaki\| Miura, Akihiro\| Araki, Kota\| Nakata, Kentaro\| Yamamoto, Hiromasa\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Shien, Tadahiko\| Yamane, Masaomi\| Azuma, Kazuo\| Okamoto, Yoshiharu\| Toyooka, Shinichi\|
Keywords	Monensin Epithelial-mesenchymal transition Non-small cell lung cancer Drug repositioning Drug resistance
Note	This fulltext is available in Jul. 2021.\|
Published Date	2020-08-27
Publication Title	Biochemical and Biophysical Research Communications
Volume	volume529
Issue	issue3
Publisher	Academic Press
Start Page	760
End Page	765
ISSN	0006-291X
NCID	AA00564395
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	32736704
DOI	10.1016/j.bbrc.2020.06.077
Web of Science KeyUT	000555780500037
Related Url	iaVersionOf https://doi.org/10.1016/j.bbrc.2020.06.077

The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas

FullText URL	fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf
Author	Yamamoto, Hiromasa\| Namba, Kei\| Yamamoto, Haruchika\| Toji, Tomohiro\| Soh, Junichi\| Shien, Kazuhiko\| Suzawa, Ken\| Kurosaki, Takeshi\| Otani, Shinji\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Yamane, Masaomi\| Takahashi, Katsuhito\| Kunisada, Toshiyuki\| Oto, Takahiro\| Toyooka, Shinichi\|
Keywords	Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR)
Note	This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. \|
Published Date	2020-08-03
Publication Title	Surgery Today
Publisher	Springer
ISSN	0941-1291
NCID	AA10824685
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	author
PubMed ID	32747982
DOI	10.1007/s00595-020-02093-5
Web of Science KeyUT	000555382600001
Related Url	isVersionOf https://doi.org/10.1007/s00595-020-02093-5

YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers

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Author	Takeda, Tatsuaki\| Yamamoto, Hiromasa\| Suzawa, Ken\| Tomida, Shuta\| Miyauchi, Shunsaku\| Araki, Kota\| Nakata, Kentaro\| Miura, Akihiro\| Namba, Kei\| Shien, Kazuhiko\| Soh, Junichi\| Shien, Tadahiko\| Kitamura, Yoshihisa\| Sendo, Toshiaki\| Toyooka, Shinichi\|
Keywords	breast cancer drug resistance lung cancer neratinib YES1
Published Date	2019-12-19
Publication Title	Cancer Science
Volume	volume111
Issue	issue3
Publisher	Wiley
Start Page	849
End Page	856
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	31856375
DOI	10.1111/cas.14289
Web of Science KeyUT	000507433400001
Related Url	isVersionOf https://doi.org/10.1111/cas.14289

Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells

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Author	Yoshioka, Takahiro\| Shien, Kazuhiko\| Takeda, Tatsuaki\| Takahashi, Yuta\| Kurihara, Eisuke\| Ogoshi, Yusuke\| Namba, Kei\| Torigoe, Hidejiro\| Sato, Hiroki\| Tomida, Shuta\| Yamamoto, Hiromasa\| Soh, Junichi\| Fujiwara, Toshiyoshi\| Toyooka, Shinichi\|
Keywords	afatinib gastric cancer HER2 MET YES1
Published Date	2019-06-04
Publication Title	Cancer Science
Volume	volume110
Issue	issue8
Publisher	Wiley Open Access
Start Page	2549
End Page	2557
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	31162771
DOI	10.1111/cas.14089
Web of Science KeyUT	000478616800022
Related Url	isVersionOf https://doi.org/10.1111/cas.14089

Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness

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Author	Chen, Youyi\| Sumardika, I Wayan\| Tomonobu, Nahoko\| Kinoshita, Rie\| Inoue, Yusuke\| Iioka, Hidekazu\| Mitsui, Yosuke\| Saito, Ken\| Ruma, I Made Winarsa\| Sato, Hiroki\| Yamauchi, Akira\| Murata, Hitoshi\| Yamamoto, Ken-ichi\| Tomida, Shuta\| Shien, Kazuhiko\| Yamamoto, Hiromasa\| Soh, Junichi\| Futami, Junichiro\| Kubo, Miyoko\| Putranto, Endy Widya\| Murakami, Takashi\| Liu, Ming\| Hibino, Toshihiko\| Nishibori, Masahiro\| Kondo, Eisaku\| Toyooka, Shinichi\| Sakaguchi, Masakiyo\|
Published Date	2019-07
Publication Title	Neoplasia
Volume	volume21
Issue	issue7
Start Page	627
End Page	640
ISSN	1522-8002
NCID	AA11470191
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 The Authors.
File Version	publisher
PubMed ID	31100639
DOI	10.1016/j.neo.2019.04.006
Web of Science KeyUT	000472189700001
Related Url	isVersionOf https://doi.org/10.1016/j.neo.2019.04.006

Study about the Efficacy of Metformin to Immune Function in Cancer Patients

JaLCDOI	10.18926/AMO/54514
FullText URL	70_4_327.pdf
Author	Watanabe, Mototsugu\| Yamamoto, Hiromasa\| Eikawa, Shingo\| Shien, Kazuhiko\| Shien, Tadahiko\| Soh, Junichi\| Hotta, Katsuyuki\| Wada, Jun\| Hinotsu, Shiro\| Fujiwara, Toshiyoshi\| Kiura, Katsuyuki\| Doihara, Hiroyoshi\| Miyoshi, Shinichiro\| Udono, Heiichiro\| Toyooka, Shinichi\|
Abstract	A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines.
Keywords	metformin CD8＋ T cells cancer immunology
Amo Type	Clinical Study Protocols
Publication Title	Acta Medica Okayama
Published Date	2016-08
Volume	volume70
Issue	issue4
Publisher	Okayama University Medical School
Start Page	327
End Page	330
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2016 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	27549683
Web of Science KeyUT	000384748600018

Preclinical Evaluation of MicroRNA-34b/c Delivery for Malignant Pleural Mesothelioma

JaLCDOI	10.18926/AMO/52140
FullText URL	68_1_23.pdf
Author	Ueno, Tsuyoshi\| Toyooka, Shinichi\| Fukazawa, Takuya\| Kubo, Takafumi\| Soh, Junichi\| Asano, Hiroaki\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Maki, Yuho\| Shien, Kazuhiko\| Furukawa, Masashi\| Sakaguchi, Masakiyo\| Yamamoto, Hiromasa\| Tsukuda, Kazunori\| Miyoshi, Shinichiro\|
Abstract	The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM.
Keywords	mesothelioma microRNA microRNA-34b/c p53
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2014-02
Volume	volume68
Issue	issue1
Publisher	Okayama University Medical School
Start Page	23
End Page	26
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2014 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	24553485
Web of Science KeyUT	000331592800004

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma

Author	Muraoka, Takayuki\| Soh, Junichi\| Toyooka, Shinichi\| Aoe, Keisuke\| Fujimoto, Nobukazu\| Hashida, Shinsuke\| Maki, Yuho\| Tanaka, Norimitsu\| Shien, Kazuhiko\| Furukawa, Masashi\| Yamamoto, Hiromasa\| Asano, Hiroaki\| Tsukuda, Kazunori\| Kishimoto, Takumi\| Otsuki, Takemi\| Miyoshi, Shinichiro\|
Published Date	2013-12
Publication Title	Lung Cancer
Volume	volume82
Issue	issue3
Content Type	Journal Article

Impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification

Author	Maki, Yuho\| Soh, Junichi\| Ichimura, Kouichi\| Shien, Kazuhiko\| Furukawa, Masashi\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Ueno, Tsuyoshi\| Yamamoto, Hiromasa\| Asano, Hiroaki\| Tsukuda, Kazunori\| Toyooka, Shinichi\| Miyoshi, Shinichiro\|
Published Date	2013-01
Publication Title	Oncology Reports
Volume	volume29
Issue	issue1
Content Type	Journal Article

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer

Author	Ueno, Tsuyoshi\| Tsukuda, Kazunori\| Toyooka, Shinichi\| Ando, Midori\| Takaoka, Munenori\| Soh, Junichi\| Asano, Hiroaki\| Maki, Yuho\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Shien, Kazuhiko\| Furukawa, Masashi\| Yamatsuji, Tomoki\| Kiura, Katsuyuki\| Naomoto, Yoshio\| Miyoshi, Shinichiro\|
Published Date	2012-04
Publication Title	Lung Cancer
Volume	volume76
Issue	issue1
Content Type	Journal Article

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer

Author	Tanaka, Norimitsu\| Toyooka, Shinichi\| Soh, Junichi\| Kubo, Takafumi\| Yamamoto, Hiromasa\| Maki, Yuho\| Muraoka, Takayuki\| Shien, Kazuhiko\| Furukawa, Masashi\| Ueno, Tsuyoshi\| Asano, Hiroaki\| Tsukuda, Kazunori\| Aoe, Keisuke\| Miyoshi, Shinichiro\|
Published Date	2012-04
Publication Title	Lung Cancer
Volume	volume76
Issue	issue1
Content Type	Journal Article

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy

Author	Shien, Kazuhiko\| Toyooka, Shinichi\| Ichimura, Kouichi\| Soh, Junichi\| Furukawa, Masashi\| Maki, Yuho\| Muraoka, Takayuki\| Tanaka, Norimitsu\| Ueno, Tsuyoshi\| Asano, Hiroaki\| Tsukuda, Kazunori\| Yamane, Masaomi\| Oto, Takahiro\| Kiura, Katsuyuki\| Miyoshi, Shinichiro\|
Published Date	2012-07
Publication Title	Lung Cancer
Volume	volume77
Issue	issue1
Content Type	Journal Article