JaLCDOI 10.18926/AMO/61217
FullText URL 74_6_557.pdf
Author Ishiguro, Mikako| Takenaka, Ryuta| Ogura, Kenichiro| Hiratsuka, Akira| Takeda, Hiromasa| Kawai, Daisuke| Tsugeno, Hirofumi| Fujiki, Shigeatsu| Okada, Hiroyuki|
Abstract A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
Keywords 5-fluorouracil dihydropyrimidine dehydrogenase deficiency DPYD variant gastric cancer
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 557
End Page 562
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361878
Web of Science KeyUT 000601203600014
NAID 120006948944
JaLCDOI 10.18926/AMO/61204
FullText URL 74_6_461.pdf
Author Kono, Yoshiyasu| Kanzaki, Hiromitsu| Iwamuro, Masaya| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Abstract Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted.
Keywords gastric cancer young patients Helicobacter pylori
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 461
End Page 466
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361865
Web of Science KeyUT 000601203600001
NAID 120006948954
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Watanabe, Natsuki| Omote, Sizuma| Matsueda, Katsunori| Tanaka, Takehiro| Ennishi, Daisuke| Otsuka, Fumio| Yoshino, Tadashi| Okada, Hiroyuki|
Keywords Flow cytometry Light chain restriction Gastrointestinal lymphoma Lymphocyte isolation
Published Date 2020
Publication Title MethodsX
Volume volume7
Publisher Elsevier
Start Page 101095
ISSN 2215-0161
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 33102158
DOI 10.1016/j.mex.2020.101095
Web of Science KeyUT 000607658800035
Related Url isVersionOf https://doi.org/10.1016/j.mex.2020.101095
FullText URL fulltext.pdf Fig1-5.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Uchida, Daisuke| Tomoda, Takeshi| Muro, Shinichiro| Okada, Hiroyuki|
Published Date 2019-09
Publication Title Endoscopy
Volume volume51
Issue issue9
Publisher Thieme Gruppe
Start Page E265
End Page E266
ISSN 0013-726X
NCID AA00635110
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31071749
DOI 10.1055/a-0896-2498
Web of Science KeyUT 000484585300014
Related Url isVersionOf https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-0896-2498
FullText URL fulltext.pdf Figure 1.jpg
Author Matsumoto, Kazuyuki| Kato, Hironari| Okada, Hiroyuki|
Note This is the peer reviewed version of the following article: Kazuyuki Matsumoto, hironari Kato and Hiroyuki Okada: Current problems and clinical results of endoscopic necrosectomy for walled‐off pancreatic necrosis. Digestive Endoscopy (2019) 31(S1), 67-68, which has been published in final form at https://doi.org/10.1111/den.13358 ]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Published Date 2019-04
Publication Title Digestive Endoscopy
Volume volume31
Issue issueS1
Publisher Wiley
Start Page 67
End Page 68
ISSN 0915-5635
NCID AA10907137
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30994230
DOI 10.1111/den.13358
Web of Science KeyUT 000465021200019
Official Url isVersionOf https://doi.org/10.1111/den.13358|
FullText URL fulltext.pdf Figures.pdf Supplemental Figures.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Kawano, Seiji| Fujiwara, Hiroyasu| Nishida, Kenji| Harada, Ryo| Fujii , Masakuni| Yoshida, Ryuichi| Umeda, Yuzo| Hinotsu, Shiro| Yagi , Takahito| Okada, Hiroyuki|
Keywords ethanol injection EUS‐guided therapy pancreatic neuroendocrine tumor scheduled therapy small size
Note This is the peer reviewed version of the following article: Kazuyuki Matsumoto et. al. Efficacy and safety of scheduled early endoscopic ultrasonography‐guided ethanol reinjection for patients with pancreatic neuroendocrine tumors: Prospective pilot study. Digestive Endoscopy (2020) 32(3), 425-430, which has been published in final form at https://doi.org/10.1111/den.13552|. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.|
Published Date 2020-03
Publication Title Digestive Endoscopy
Volume volume32
Issue issue3
Publisher Wiley
Start Page 425
End Page 430
ISSN 0915-5635
NCID AA10907137
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31580507
DOI 10.1111/den.13552
Web of Science KeyUT 000494577300001
Related Url isVersionOf https://doi.org/10.1111/den.13552
FullText URL fulltext.pdf Figures 1-2.pdf Figures Sa-b.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Nishida, Kenji| Okada, Hiroyuki|
Published Date 2019-07
Publication Title Digestive and Liver Disease
Volume volume51
Issue issue7
Publisher Elsevier
Start Page 1060
ISSN 1590-8658
NCID AA11610665
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30975613
DOI 10.1016/j.dld.2019.03.006
Web of Science KeyUT 000471879200021
Related Url isVersionOf https://doi.org/10.1016/j.dld.2019.03.006
FullText URL fulltext.pdf Fig_1-4.pdf
Author Ishihara, Yuki| Matsumoto, Kazuyuki| Kato, Hironari| Tsutsumi, Koichiro| Tomoda, Takeshi| Matsumi, Akihiro| Miyamoto, Kazuya| Yamazaki, Tatsuhiro| Saragai, Yosuke| Fujii, Yuki| Uchida, Daisuke| Horiguchi, Shigeru| Okada, Hiroyuki|
Keywords Peroral direct cholangioscopy Hepatolithiasis Altered gastrointestinal anatomy Double-balloon endoscopy
Note This is an Accepted Manuscript of an article published by Springer.|
Published Date 2020-11-02
Publication Title Surgical Endoscopy
Volume volume35
Publisher Springer
Start Page 1895
End Page 1902
ISSN 0930-2794
NCID AA10750363
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33140150
DOI 10.1007/s00464-020-08139-6
Web of Science KeyUT 000584333800003
Related Url isVersionOf https://doi.org/10.1007/s00464-020-08139-6
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Takahashi, Takahide| Tanaka, Takehiro| Toji, Tomohiro| Hiraoka, Sakiko| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Published Date 2020-10-07
Publication Title Case Reports in Gastrointestinal Medicine
Volume volume2020
Publisher Hindawi
Start Page 8893604
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Masaya Iwamuro et al.
File Version publisher
PubMed ID 33083067
DOI 10.1155/2020/8893604
Web of Science KeyUT 000583201400001
Related Url isVersionOf https://doi.org/10.1155/2020/8893604
FullText URL fulltext.pdf Figure.tif
Author Tomoda, Takeshi| Kato, Hironari| Miyamoto, Kazuya| Matsumi, Akihiro| Ueta, Eijiro| Fujii, Yuuki| Saragai, Yousuke| Yamazaki, Tatsuhiro| Uchida, Daisuke| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Okada, Hiroyuki|
Keywords diclofenac low dose post‐ERCP pancreatitis
Note This is the peer reviewed version of the following article: Takeshi Tomoda et. al. Efficacy of low dose rectal diclofenac for preventing post‐endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score‐matched analysis. Digestive Endoscopy, which has been published in final form at https://doi.org/10.1111/den.13828. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.|
Published Date 2020-09-02
Publication Title Digestive Endoscopy
Volume volume33
Publisher Wiley
Start Page 656
End Page 662
ISSN 0915-5635
NCID AA10907137
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 32881078
DOI 10.1111/den.13828
Web of Science KeyUT 000577757600001
Related Url isVersionOf https://doi.org/10.1111/den.13828
FullText URL fulltext.pdf
Author Miyamoto, Kazuya| Matsumoto, Kazuyuki| Kato, Hironari| Yoshida, Ryuichi| Umeda, Yuzo| Inoue, Hirohumi| Tanaka, Takehiro| Matsumi, Akihiro| Saragai, Yosuke| Fujii, Yuki| Yamazaki, Tatsuhiro| Uchida, Daisuke| Tomoda, Takeshi| Horiguchi, Shigeru| Yagi, Takahito| Okada, Hiroyuki|
Keywords IPMN PJC LBC BD SurePath
Published Date 2020-09-29
Publication Title BMC Gastroenterology
Volume volume20
Issue issue1
Publisher BMC
Start Page 319
ISSN 1471-230X
NCID AA12034934
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32993498
DOI 10.1186/s12876-020-01465-y
Web of Science KeyUT 000576989100004
Related Url isVersionOf https://doi.org/10.1186/s12876-020-01465-y
FullText URL fulltext.pdf
Author Matsumoto, Kazuyuki| Kato, Hironari| Horiguchi, Shigeru| Tomoda, Takeshi| Matsumi, Akihiro| Ishihara, Yuki| Saragai, Yosuke| Takada, Saimon| Muro, Shinichiro| Uchida, Daisuke| Okada, Hiroyuki|
Keywords Endoscopic ultrasound-guided fine needle aspiration Pancreaticobiliary cancer Neoplasm recurrence
Published Date 2020
Publication Title Gut and Liver
Volume volume14
Issue issue5
Publisher Gut and Liver
Start Page 652
End Page 658
ISSN 1976-2283
NCID AA12329814
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 31818050
NAID 120006891207
DOI 10.5009/gnl19200
Web of Science KeyUT 000569359000016
Related Url isVersionOf https://doi.org/10.5009/gnl19200
FullText URL fulltext.pdf
Author Hirai, Mami| Kinugasa, Hideaki| Nouso, Kazuhiro| Yamamoto, Shumpei| Terasawa, Hiroyuki| Onishi, Yuma| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Onishi, Hideki| Shiraha, Hidenori| Takaki, Akinobu| Okada, Hiroyuki|
Keywords ctDNA hepatocellular carcinoma liquid biopsy prediction prognosis TERT promoter mutation
Published Date 2020-08-24
Publication Title Journal of Gastroenterology and Hepatology
Volume volume36
Publisher Wiley
Start Page 1118
End Page 1125
ISSN 0815-9319
NCID AA10727383
Content Type Journal Article
File Version author
PubMed ID 32830343
DOI 10.1111/jgh.15227
Web of Science KeyUT 000568136400001
Related Url isVersionOf https://doi.org/10.1111/jgh.15227
FullText URL fulltext.pdf Figure_A.tif Figure_B.tif Figure_C.tif Figure_D.tif
Author Ako, Soichiro| Kawano, Seiji| Okada, Hiroyuki|
Published Date 2020-07-23
Publication Title Clinical Gastroenterology and Hepatology
Volume volume20
Issue issue2
Publisher AGA Institute
Start Page e12
End Page e13
ISSN 15423565
NCID AA11845942
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the AGA Institute
File Version author
PubMed ID 32712389
DOI 10.1016/j.cgh.2020.07.044
Related Url isVersionOf https://doi.org/10.1016/j.cgh.2020.07.044
JaLCDOI 10.18926/AMO/60364
FullText URL 74_4_275.pdf
Author Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki|
Abstract Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.
Keywords oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 275
End Page 283
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843758
Web of Science KeyUT 000562508700002
NAID 120006880203
JaLCDOI 10.18926/AMO/60363
FullText URL 74_4_265.pdf
Author Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun|
Abstract Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy.
Keywords Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-08
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 265
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843757
Web of Science KeyUT 000562508700001
NAID 120006880202
FullText URL fulltext.pdf
Author Uchida, Daisuke| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Onishi, Hideki| Okada, Hiroyuki|
Keywords oxidative stress chronic hepatitis hepatocellular carcinoma
Published Date 2020-05-28
Publication Title Nutrients
Volume volume12
Issue issue6
Publisher MDPI
Start Page 1576
ISSN 2072-6643
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 by the authors.
File Version publisher
PubMed ID 32481552
DOI 10.3390/nu12061576
Web of Science KeyUT 000554005200001
Related Url isVersionOf https://doi.org/10.3390/nu12061576
FullText URL fulltext.pdf
Author Tanabe, Katsuyuki| Kanzaki, Hiromitsu| Wada, Takahira| Nakashima, Yuri| Sugiyama, Hitoshi| Okada, Hiroyuki| Wada, Jun|
Keywords case report gastric cancer IgA nephropathy nivolumab steroid
Published Date 2020-05-22
Publication Title Medicine
Volume volume99
Issue issue21
Publisher Lippincott, Williams & Wilkins
Start Page e20464
ISSN 0025-7974
NCID AA00728867
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 the Author(s).
File Version publisher
PubMed ID 32481351
DOI 10.1097/MD.0000000000020464
Web of Science KeyUT 000551508200106
Related Url isVersionOf https://doi.org/10.1097/MD.0000000000020464
FullText URL fulltext.pdf
Author Yamamoto, Shumpei| Onishi, Hideki| Takaki, Akinobu| Oyama, Atsushi| Adachi, Takuya| Wada, Nozomu| Sakata, Masahiro| Yasunaka, Tetsuya| Shiraha, Hidenori| Okada, Hiroyuki|
Keywords Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Low-dose cisplatin plus 5-fluorouracil alpha-Fetoprotein Des-gamma-carboxy prothrombin
Published Date 2020-04-21
Publication Title Gastrointestinal Tumors
Volume volume7
Issue issue3
Publisher Karger
Start Page 83
End Page 92
ISSN 2296-3774
NCID AA12665877
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s)
File Version publisher
DOI 10.1159/000506941
Web of Science KeyUT 000551254300003
Related Url isVersionOf https://doi.org/10.1159/000506941
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Murakami, Toshi| Tanaka, Takehiro| Oka, Shohei| Kawano, Seiji| Kawahara, Yoshiro| Okada, Hiroyuki|
Published Date 2020-06-04
Publication Title Case Reports in Gastrointestinal Medicine
Volume volume2020
Publisher Hindawi
Start Page 6381670
ISSN 2090-6528
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Masaya Iwamuro et al.
File Version publisher
PubMed ID 32566328
DOI 10.1155/2020/6381670
Web of Science KeyUT 000542326600001
Related Url isVersionOf https://doi.org/10.1155/2020/6381670