| ID | 61217 |
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| Author |
Ishiguro, Mikako
Department of Internal Medicine, Tsuyama Chuo Hospital
Takenaka, Ryuta
Department of Internal Medicine, Tsuyama Chuo Hospital
Ogura, Kenichiro
Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Hiratsuka, Akira
Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Takeda, Hiromasa
Department of Internal Medicine, Tsuyama Chuo Hospital
Kawai, Daisuke
Department of Internal Medicine, Tsuyama Chuo Hospital
Tsugeno, Hirofumi
Department of Internal Medicine, Tsuyama Chuo Hospital
Fujiki, Shigeatsu
Department of Internal Medicine, Tsuyama Chuo Hospital
Okada, Hiroyuki
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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| Abstract | A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydroge-nase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at posi-tions 1615 (G > A), 1627 (A > G), and 1896 (T > C) in exons 13, 13, and 14, respectively.
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| Keywords | 5-fluorouracil
dihydropyrimidine dehydrogenase deficiency
DPYD variant
gastric cancer
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| Amo Type | Case Report
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| Publication Title |
Acta Medica Okayama
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| Published Date | 2020-12
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| Volume | volume74
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| Issue | issue6
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| Publisher | Okayama University Medical School
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| Start Page | 557
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| End Page | 562
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| ISSN | 0386-300X
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| NCID | AA00508441
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| Content Type |
Journal Article
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| language |
English
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| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School
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| File Version | publisher
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| Refereed |
True
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