| ID | 62852 |
| FullText URL | |
| Author |
Gotoh, Kazuyoshi
Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Mayura, I. Putu Bayu
Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Enomoto, Yusaku
Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Iio, Koji
Microbiology Division, Clinical Laboratory, Okayama University Hospital
Matsushita, Osamu
Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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Otsuka, Fumio
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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Hagiya, Hideharu
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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| Abstract | The emergence of high-level daptomycin (DAP)-resistant (HLDR) Corynebacterium striatum has been reported as a result of loss-of-function point mutations or premature stop codon mutations in a responsible gene, pgsA2. We herein describe the novel detection of an HLDR C. striatum clinical isolate, in which IS30-insertion was corroborated to cause destruction of pgsA2 gene. We isolated an HLDR C. striatum from a critically ill patient with underlying mycosis fungoides who had been treated with DAP for ten days. With a sequence investigation, IS30-insertion was discovered to split pgsA2 in the HLDR C. striatum strain, which may cause disrupted phospholipid phosphatidylglycerols (PG) production. Future studies should survey the prevalence of IS-mediated gene inactivation among HLDR C. striatum clinical isolates.
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| Keywords | Antimicrobial Resistance
Daptomycin resistance
Corynebacterium striatum
Insertion sequence
pgsA2 gene
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| Note | This is an Accepted Manuscript of an article published by Springer.
This fulltext is available in Oct. 2022. |
| Published Date | 2021-10-21
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| Publication Title |
European Journal of Clinical Microbiology & Infectious Diseases
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| Volume | volume41
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| Issue | issue2
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| Publisher | Springer Science and Business Media LLC
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| Start Page | 331
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| End Page | 333
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| ISSN | 0934-9723
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature
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| File Version | author
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| Related Url | isVersionOf https://doi.org/10.1007/s10096-021-04369-1
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| Citation | Gotoh, K., Mayura, I.P.B., Enomoto, Y. et al. Detection of in-frame mutation by IS30-family insertion sequence in the phospholipid phosphatidylglycerol synthase gene (pgsA2) of high-level daptomycin-resistant Corynebacterium striatum. Eur J Clin Microbiol Infect Dis (2021). https://doi.org/10.1007/s10096-021-04369-1
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