JaLCDOI 10.18926/AMO/53679
FullText URL 69_5_319.pdf
Author Hagiya, Hideharu| Iwamuro, Masaya| Tanaka, Takehiro| Hanayama, Yoshihisa| Otsuka, Fumio|
Abstract A 60-year-old woman with rheumatoid arthritis treated with methotrexate for a decade complained of slight epigastric discomfort. A positive cytomegalovirus (CMV) antigenemia test indicated the probability of CMV-related gastrointestinal infection, for which esophagogastroduodenoscopy was performed. Endoscopic findings showed a non-specific duodenal mucosal lesion;however, pathological investigation revealed evidence of CMV duodenitis. There is scarce information on the clinical and pathological features of CMV-related duodenitis, likely due to its low prevalence. CMV infection in the upper gastrointestinal tract should be considered as a differential diagnosis in high-risk individuals, particularly those with symptoms relating to the digestive system. Biopsy examinations are preferable for the definitive diagnosis of CMV gastrointestinal infection, even without specific endoscopic features.
Keywords antigenemia cytomegalovirus (CMV) gastrointestinal infection methotrexate opportunistic infection
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2015-10
Volume volume69
Issue issue5
Publisher Okayama University Medical School
Start Page 319
End Page 323
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 26490030
Web of Science KeyUT 000365519600009
JaLCDOI 10.18926/AMO/54422
FullText URL 70_3_217.pdf
Author Waseda, Koichi| Ocho, Kazuki| Hasegawa, Kou| Kimura, Kosuke| Iwamuro, Masaya| Hanayama, Yoshihisa| Kondo, Eisei| Miyahara, Nobuaki| Otsuka, Fumio|
Abstract KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.
Keywords KL-6 mycobacterium avium complex pulmonary nontuberculous mycobacterium infection rheumatoid arthritis-associated interstitial lung disease bronchial alveolar lavage
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2016-06
Volume volume70
Issue issue3
Publisher Okayama University Medical School
Start Page 217
End Page 221
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27339212
Web of Science KeyUT 000379406100010
JaLCDOI 10.18926/AMO/54504
FullText URL 70_4_279.pdf
Author Nishimura, Yoshito| Iwamuro, Masaya| Ocho, Kazuki| Hasegawa, Kou| Kimura, Kosuke| Hanayama, Yoshihisa| Kondo, Eisei| Tanaka, Takehiro| Otsuka, Fumio|
Abstract A 61-year-old Japanese man with IgG4-related autoimmune pancreatitis was referred to our hospital because of perspiration during food intake. Abdominal computed tomography (CT) with contrast media revealed multiple mesenteric lymphadenopathies. An open surgical abdominal biopsy and subsequent histopathological analysis revealed abnormally large lymphoid cells that were negative for CD3, CD5, and c-myc and positive for CD20 and bcl-2, leading to a diagnosis of diffuse large B-cell lymphoma. Here, we discuss the risk of malignancies, particularly malignant lymphoma in patients with IgG4-related disease. The importance of pathological analysis to reach the appropriate diagnosis in such cases should be emphasized.
Keywords IgG4-related disease autoimmune pancreatitis immunophenotyping diffuse large B-cell lymphoma
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2016-08
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 279
End Page 283
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549673
Web of Science KeyUT 000384748600008
Author Iwamuro, Masaya| Urata, Haruo| Tanaka, Takehiro| Ando, Akemi| Nada, Takahiro| Kimura, Kosuke| Yamauchi, Kenji| Kusumoto, Chiaki| Otsuka, Fumio| Okada, Hiroyuki|
Published Date 2017-02
Publication Title Acta Medica Okayama
Volume volume71
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/54828
JaLCDOI 10.18926/AMO/54977
FullText URL 71_2_97.pdf
Author Iwamuro, Masaya| Kondo, Eisei| Tanaka, Takehiro| Hagiya, Hideharu| Kawano, Seiji| Kawahara, Yoshiro| Otsuka, Fumio| Okada, Hiroyuki|
Abstract We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). All 14 patients had been taking one or more immunosuppressive agents including cyclosporine (n=10), corticosteroids (n=9), mycophenolic acid (n=6), tacrolimus (n=3), and methotrexate (n=1). Tests for CMV antigenemia were positive in 11 patients (78.6%). EGD examinations revealed esophageal (n=3), gastric (n=9), and duodenal involvement (n=6). Macroscopically, esophageal lesions by CMV infection presented as redness (n=1), erosions (n=1), and ulcers (n=1). Gastric lesions manifested as redness (n=7), erosions (n=3), exfoliated mucosa (n=2), and verrucous erosions (n=1). Mucosal appearances in the duodenum varied: redness (n=2), ulcers (n=2), multiple erosions (n=2), single erosion (n=1), edema (n=1). CMV was detected even in the intact duodenal mucosa (n=1). In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients.
Keywords cytomegalovirus duodenum esophagogastroduodenoscopy esophagus stomach
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2017-04
Volume volume71
Issue issue2
Publisher Okayama University Medical School
Start Page 97
End Page 104
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28420890
FullText URL BMCMedEduc_19_1_87.pdf
Author Yamamoto, Akira| Obika, Mikako| Mandai, Yasuhiro| Murakami, Taku| Miyoshi, Tomoko| Ino, Hideo| Kataoka, Hitomi| Otsuka, Fumio|
Keywords Simulation-based learning Peer-assisted learning Lecture Postgraduate education Junior residents
Published Date 2019-03-20
Publication Title BMC Medical Education
Volume volume19
Issue issue1
Publisher BMC
Start Page 87
ISSN 1472-6920
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
PubMed ID 30894162
DOI 10.1186/s12909-019-1509-y
Web of Science KeyUT 000462328100001
Related Url isVersionOf https://doi.org/10.1186/s12909-019-1509-y
FullText URL CTR375_3_743.pdf
Author Ojima, Fumiya| Saito, Yuka| Tsuchiya, Yukiko| Ogoshi, Maho| Fukamachi, Hiroshi| Inagaki, Kenichi| Otsuka, Fumio| Takeuchi, Sakae| Takahashi, Sumio|
Keywords Estrogen Follicle Mouse Ovary Runx3
Published Date 2018-10-30
Publication Title Cell and Tissue Research
Volume volume375
Issue issue3
Publisher Springer
Start Page 743
End Page 754
ISSN 0302-766X
NCID AA00600105
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30377784
DOI 10.1007/s00441-018-2947-2
Web of Science KeyUT 000460535300015
Related Url isVersionOf https://doi.org/10.1007/s00441-018-2947-2
JaLCDOI 10.18926/AMO/57711
FullText URL 73_6_479.pdf
Author Suganami, Yu| Oka, Kosuke| Hanayama, Yoshihisa| Honda, Hiroyuki| Hamahara, Jun| Obika, Mikako| Kariyama, Kazuya| Kishida, Masayuki| Otsuka, Fumio|
Abstract To clarify the potential relevance of patients’ chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger patients. The FSSG score did not differ by gender but was higher in younger patients. The patients receiving social welfare had higher SDS and FSSG scores. A close inter-relationship between the FSSG (including both degrees of reflux and dysmotility) and SDS was observed in all patients. Although the averages of the SDS and FSSG scores were not significantly different among the symptom-based categories, we observed significantly positive correlations between the FSSG and SDS in each category, suggesting that depressive status may be closely related to GERD-related symptoms regardless of the patients’ chief complaints. An initial checkup of patients’ psychological condition and/or GERD-like symptoms could help screen for latent disorders in outpatients with uncertain complaints.
Keywords chief complaints frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) self-rating depression scale (SDS) welfare
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2019-12
Volume volume73
Issue issue6
Publisher Okayama University Medical School
Start Page 479
End Page 486
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31871329
Web of Science KeyUT 000503431400002
FullText URL CCR7_5_1108.pdf
Author Nishimura, Yoshito| Yamamoto, Akira| Takahara, Masahiro| Otsuka, Fumio|
Keywords follicular lymphoma and PET-CT mesenteric tumors
Published Date 2019-04-12
Publication Title Clinical Case Reports
Volume volume7
Issue issue5
Publisher Wiley
Start Page 1108
End Page 1109
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31110757
DOI 10.1002/ccr3.2148
Web of Science KeyUT 000467564200055
Related Url isVersionOf https://doi.org/10.1002/ccr3.2148
FullText URL IM58_2_311.pdf
Author Nishimura, Yoshito| Yasuda, Miho| Hasegawa, Kou| Otsuka, Fumio|
Keywords adrenal medullary hyperplasia stroke hypertension and catecholamines
Published Date 2019-01-15
Publication Title Internal Medicine
Volume volume58
Issue issue2
Start Page 311
End Page 311
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders 2019 (c) The Japanese Society of Internal Medicine
File Version author
PubMed ID 30146579
DOI 10.2169/internalmedicine.1182-18
Web of Science KeyUT 000455930700027
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.1182-18
JaLCDOI 10.18926/AMO/57950
FullText URL 74_1_33.pdf
Author Honda, Hiroyuki| Hanayama, Yoshihisa| Obika, Mikako| Hasegawa, Kou| Hamahara, Jun| Kishida, Masayuki| Hagiya, Hideharu| Ogawa, Hiroko| Kataoka, Hitomi| Otsuka, Fumio|
Abstract A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients’ gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups’ characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients’ SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients’ PPG levels were correlated with GERD-related symptoms, diabetic patients’ blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful
Keywords blood glucose type 2 diabetes mellitus gastroesophageal reflux depressive status postprandial plasma glucose
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-02
Volume volume74
Issue issue1
Publisher Okayama University Medical School
Start Page 33
End Page 40
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32099246
Web of Science KeyUT 000516606200005
NAID 120006795617
FullText URL IM58_5_765.pdf
Author Sugihara, Yuusaku| Ogawa, Hiroko| Otsuka, Fumio|
Keywords crowned dense syndrome hyperuricemia
Published Date 2019-03-01
Publication Title Internal Medicine
Volume volume58
Issue issue5
Publisher Japanese Society of Internal Medicine
Start Page 765
End Page 765
ISSN 0918-2918
NCID AA10827774
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 by The Japanese Society of Internal Medicine
File Version author
PubMed ID 30333410
DOI 10.2169/internalmedicine.1589-18
Web of Science KeyUT 000460285100029
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.1589-18
Title Alternative Revision of the postgraduate clinical training system
FullText URL 131_159.pdf
Author Sato, Asuka| Ogawa, Hiroko| Miyoshi, Tomoko| Otsuka, Fumio|
Keywords 医師臨床研修制度 (postgraduate clinical training system) 研修医 (resident)
Publication Title Journal of Okayama Medical Association
Published Date 2019-12-02
Volume volume131
Issue issue3
Start Page 159
End Page 160
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.131.159
language Japanese
Copyright Holders Copyright (c) 2019 岡山医学会
File Version publisher
DOI 10.4044/joma.131.159
NAID 130007782625
FullText URL fulltext.pdf table.pdf figure.pptx
Author Nishimura, Yoshito| Hanayama, Yoshihisa| Fujii, Nobuharu| Kondo, Eisei| Otsuka, Fumio|
Keywords TAFRO syndrome Castleman disease chief complaint procalcitonin immunoglobulin
Note This is the peer reviewed version of the following article: Nishimura Y. et. al. Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study. Internal Medicine Journal 50(2), 184-191 (2020), which has been published in final form at https://doi.org/10.1111/imj.14404. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
This fulltext is available in Feb. 2021.|
Published Date 2019-06-18
Publication Title Internal Medicine Journal
Volume volume50
Issue issue2
Publisher Wiley
Start Page 184
End Page 191
ISSN 14440903
NCID AA1156202X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 31211492
DOI 10.1111/imj.14404
Web of Science KeyUT 000529458300007
Related Url isVersionOf https://doi.org/10.1111/imj.14404
FullText URL fulltext.pdf
Author Ueda, Yayoi| Tokumasu, Kazuki| Hagiya, Hideharu| Iio, Koji| Fujimori, Takumi| Kakehi, Ayaka| Okura, Mami| Minabe, Hiroshi| Otsuka, Fumio|
Keywords Mycobacterium chelonae Mycobacteremia Non-tuberculous mycobacteria Osteomyelitis Rapidly growing mycobacteria Rheumatoid arthritis
Note This fulltext is available in May 2021.|
Published Date 2020-05-11
Publication Title Journal of Infection and Chemotherapy
Volume volume26
Issue issue8
Publisher Elsevier
Start Page 843
End Page 846
ISSN 1341321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd.
File Version author
PubMed ID 32402735
DOI 10.1016/j.jiac.2020.03.004
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2020.03.004
FullText URL fulltext.pdf
Author Harada, Ko| Murakami, Shuntaro| Tokumasu, Kazuki| Togawa, Yu| Otsuka, Fumio|
Keywords hypercapnic respiratory failure myxedema coma sick sinus syndrome
Published Date 2019-06-25
Publication Title Journal of General and Family Medicine
Volume volume20
Issue issue5
Publisher Wiley
Start Page 206
End Page 208
ISSN 2189-7948
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31516809
DOI 10.1002/jgf2.267
Web of Science KeyUT 000484673300008
Related Url isVersionOf https://doi.org/10.1002/jgf2.267
FullText URL fulltext.pdf
Author Sazumi, Yosuke| Nishimura, Yoshito| Otsuka, Yuki| Mizuta, Yuki| Nakano, Yasuhiro| Sakae, Hiroyuki| Otsuka, Fumio|
Keywords extrahepatic portosystemic shunt hepatic encephalopathy portal hypertension and altered mental status
Published Date 2020-06-01
Publication Title Clinical Case Reports
Volume volume8
Issue issue9
Publisher Wiley
Start Page 1852
End Page 1853
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
DOI 10.1002/ccr3.2986
Web of Science KeyUT 000536667000001
Related Url isVersionOf https://doi.org/10.1002/ccr3.2986
FullText URL fulltext.pdf
Author Yamamoto, Akira| Nishimura, Yoshito| Obika, Mikako| Morizane, Yuki| Otsuka, Fumio|
Keywords anemia anemic retinopathy rectal cancer retinal detachment
Published Date 2020-04-13
Publication Title Clinical Case Reports
Volume volume8
Issue issue7
Publisher Wiley
Start Page 1304
End Page 1305
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
NAID 120006862787
DOI 10.1002/ccr3.2833
Web of Science KeyUT 000525973300001
Related Url isVersionOf https://doi.org/10.1002/ccr3.2833
FullText URL fulltext.pdf
Author Nishimura, Yoshito| Hagiya, Hideharu| Kawano, Kaoru| Yokota, Yuya| Oka, Kosuke| Iio, Koji| Hasegawa, Kou| Obika, Mikako| Haruma, Tomoko| Ono, Sawako| Masuyama, Hisashi| Otsuka, Fumio|
Keywords Non-typable Haemophilus influenzae Bacteremia beta-Lactamase-nonproducing ampicillin-resistance Adenomyosis Case report
Published Date 2020-07-16
Publication Title BMC Infectious Diseases
Volume volume20
Issue issue1
Publisher BMC
Start Page 521
ISSN 1471-2334
NCID AA1203502X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 32678023
DOI 10.1186/s12879-020-05193-2
Web of Science KeyUT 000552431500010
Related Url isVersionOf https://doi.org/10.1186/s12879-020-05193-2
FullText URL fulltext.pdf
Author Yoshida, Satoru| Okura, Hanayuki| Suga, Hidetaka| Soen, Mika| Kawaguchi, Yohei| Kurimoto, Junki| Miyata, Takashi| Takagi, Hiroshi| Arima, Hiroshi| Fujikawa, Tatsuya| Otsuka, Fumio| Matsuyama, Akifumi|
Published Date 2020-10
Publication Title Stem Cell Research
Volume volume48
Publisher Elsevier
Start Page 101960
ISSN 1873-5061
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors
File Version publisher
PubMed ID 32927425
DOI 10.1016/j.scr.2020.101960
Related Url isVersionOf https://doi.org/10.1016/j.scr.2020.101960