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Author Nakamura, Keiichiro| Matsuoka, Hirofumi| Kubo, Kotaro| Shirakawa, Shinsuke| Ida, Naoyuki| Haraga, Junko| Ogawa, Chikako| Okamoto, Kazuhiro| Nagao, Shoji| Masuyama, Hisashi|
Keywords returning to the same workplace gynecologic neoplasms sick leave
Published Date 2023-11-23
Publication Title Japanese Journal of Clinical Oncology
Volume volume54
Issue issue3
Publisher Oxford University Press (OUP)
Start Page 292
End Page 296
ISSN 1465-3621
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2023.
File Version publisher
PubMed ID 37995280
DOI 10.1093/jjco/hyad159
Web of Science KeyUT 001108594700001
Related Url isVersionOf https://doi.org/10.1093/jjco/hyad159
FullText URL fulltext.pdf
Author Mitoma, Tomohiro| Maki, Jota| Ooba, Hikaru| Ogawa, Chikako| Masuyama, Hisashi| Tabuchi, Takahiro|
Keywords cervical cancer screening social inequality screening hesitation internet survey
Published Date 2024-02-13
Publication Title International Journal of General Medicine
Volume volume17
Publisher Dove Press
Start Page 541
End Page 551
ISSN 1178-7074
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 Mitoma et al.
File Version publisher
PubMed ID 38371520
DOI 10.2147/IJGM.S453675
Web of Science KeyUT 001162765400001
Related Url isVersionOf https://doi.org/10.2147/IJGM.S453675
JaLCDOI 10.18926/AMO/63406
FullText URL 76_2_129.pdf
Author Kubo, Kotaro| Nakamura, Keiichiro| Okamoto, Kazuhiro| Matsuoka, Hirofumi| Ida, Naoyuki| Haruma, Tomoko| Ogawa, Chikako| Masuyama, Hisashi|
Abstract Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
Keywords D-dimer gynecologic cancer venous thromboembolism
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2022-04
Volume volume76
Issue issue2
Publisher Okayama University Medical School
Start Page 129
End Page 135
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2022 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 35503440
Web of Science KeyUT 000792374900004
JaLCDOI 10.18926/AMO/62816
FullText URL 75_6_745.pdf
Author Hayata, Kei| Mishima, Sakurako| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eto, Eriko| Ogawa, Chikako| Masuyama, Hisashi|
Abstract NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results.
Keywords NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-12
Volume volume75
Issue issue6
Publisher Okayama University Medical School
Start Page 745
End Page 750
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34955544
Web of Science KeyUT 000735319800002
NAID 120007180276
FullText URL fulltext.pdf
Author Okamoto, Kazuhiro| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Ogawa, Chikako| Masuyama, Hisashi|
Keywords gynecological cancer chronic diseases occurrence risk factors
Published Date 2020-01-29
Publication Title Molecular and Clinical Oncology
Volume volume12
Issue issue4
Publisher Spandidos Publications
Start Page 336
End Page 342
ISSN 2049-9450
NCID AA12610944
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Okamoto et al.
File Version publisher
PubMed ID 32190316
DOI 10.3892/mco.2020.1989
Web of Science KeyUT 000523727300007
Related Url isVersionOf https://doi.org/10.3892/mco.2020.1989
JaLCDOI 10.18926/AMO/58268
FullText URL 74_2_109.pdf
Author Ogawa, Chikako| Nakamura, Keiichiro| Matsuoka, Hirofumi| Matsubara, Yuko| Haraga, Junko| Masuyama, Hisashi|
Abstract This study aimed to determine whether the risk conferred by gynecologic cancer (GC) as second primary cancer (SPC) differs from that associated with GC as first primary cancer (FPC). We investigated the correlations between FPC/SPC and the characteristics and prognoses of 1,645 GC patients (701 with cervical cancer [CC], 641 with endometrial cancer [EM], and 303 with ovarian cancer [OV]). The χ2 test and the Kaplan–Meier method were used to determine whether FPC/SPC and the characteristics and prognoses of GC patients. Of the SPC patients, 26 (3.7%) had CC, 53 (8.3%) had EM, and 31 (10.2%) had OV. The most common previous cancer type in SPC of GC patients was breast cancer, which was observed in 13 patients (50.0%) with CC, 23 (43.4%) with EM, and 16 (51.6%) with OV. In all patients with CC, EM, and OV as SPC, the stage was significantly associated with recurrence. There were no significant differences in the morbidity or mortality of CC, EM, or OV patients between those with FPC and those with SPC. The risk of SPC development in GC patients varied, ranging from 3.5% (CC) to 10.3% (OV) of patients.
Keywords second primary cancer gynecologic cancer prognosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-04
Volume volume74
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 114
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32341584
Web of Science KeyUT 000528278500003
NAID 120006839447
Title Alternative A preoperative SUVmax greater than the ADCmin of the primary tumour : A predictor of disease recurrence and survival in patients with endometrial cancer
FullText URL 126_11.pdf
Author Nakamura, Keiichiro| Joja, Ikuo| Fukushima, Chikako| Haruma, Tomoko| Hayashi, Chiaki| Kusumoto, Tomoyuki| Seki, Noriko| Hongo, Atsushi| Hiramatsu, Yuji|
Keywords endometrial cancer SUVmax PET/CT predictor of poor prognosis
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 11
End Page 15
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language Japanese
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.11