ID | 60246 |
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Author |
Yamamoto, Haruchika
Department of General Thoracic Surgery, Okayama University Hospital
Sugimoto, Seiichiro
Department of General Thoracic Surgery, Okayama University Hospital
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Kurosaki, Takeshi
Department of Organ Transplant Center, Okayama University Hospital
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Miyoshi, Kentaroh
Department of Organ Transplant Center, Okayama University Hospital
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Otani, Shinji
Department of General Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio
Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi
Department of General Thoracic Surgery, Okayama University Hospital
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Toyooka, Shinichi
Department of General Thoracic Surgery, Okayama University Hospital
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Abstract | Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. The unilateral shift values on Q-scinti were calculated and compared between the CLAD group (N=27) and the non-CLAD group (N=31) from 5 years before to 5 years after the diagnosis of CLAD. The unilateral shift values in Q-scinti were significantly higher in the CLAD group than in the non-CLAD group from 5 years before the diagnosis of CLAD to 5 years after the diagnosis (P<0.05). The unilateral shift values in Q-scinti were significantly correlated with the percent baseline values of the forced expiratory volume in 1 s (P=0.0037), the total lung capacity (P=0.0028), and the forced vital capacity (P=0.00024) at the diagnosis of CLAD. In patients developing unilateral CLAD after bilateral LDLLT, Q-scinti showed a unilateral perfusion shift to the contralateral unaffected lung. Thus, Q-scinti appears to have the potential to predict unilateral CLAD after bilateral LDLLT.
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Published Date | 2020-06-29
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Publication Title |
Scientific Reports
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Volume | volume10
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Issue | issue1
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Publisher | Nature
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Start Page | 10595
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ISSN | 2045-2322
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2020
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File Version | publisher
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DOI | |
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Related Url | isVersionOf https://doi.org/10.1038/s41598-020-67433-4
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License | http://creat iveco mmons .org/licen ses/by/4.0/
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Funder Name |
Ministry of Education, Culture, Sports, Science and Technology
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助成番号 | 19K09305
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