ID | 52797 |
FullText URL | |
Author |
Nishikawa, Hitoshi
Otani, Shinji
Harada, Masaaki
Iga, Norichika
Miyoshi, Kentaroh
Kaken ID
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Abstract | Objective: The shortage of organ donors is a serious problem in Japan. The right and left upper lobes of rejected extended-criteria lungs have the potential to be used for downsized lung transplantation; however, the 2 upper lobes are too small for a size-matched recipient. The present study investigated the feasibility of unilateral transplantation using the right and left upper lobes.
Methods: After harvesting the heart-lung block from donor swine, a left lung graft was created using the right and left upper lobes and transplanted into the left thoracic space of the recipient swine (group A, n = 5). We then evaluated graft function for 6 hours and compared these results with those of a control group (group B, n = 5), in which orthotopic left lung transplantation had been performed.
Results: The mean partial pressure of oxygen in the arterial blood gas after reperfusion was 507 mm Hg in group A and 463 mm Hg in group B (P = .2). The mean pulmonary arterial pressure was 30.3 mm Hg in group A and 27.5 mm Hg in group B (P = .4). The mean airway pressure was 6.4 mm Hg in group A and 6.2 mm Hg in group B (P = .7).
Conclusions: Our results suggest that unilateral left lung transplantation using the right and left upper lobes is technically and functionally feasible for size-matched recipients. In addition, this technique enables the use of rejected lungs if the upper lobes are still intact.
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Published Date | 2013-12
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Publication Title |
The Journal of Thoracic and Cardiovascular Surgery
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Volume | volume146
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Issue | issue6
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Start Page | 1534
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End Page | 1537
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ISSN | 0022-5223
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Content Type |
Journal Article
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Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52521
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language |
English
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File Version | author
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Refereed |
True
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DOI | |
Web of Science KeyUT |