ID | 66976 |
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Author |
Nakanishi, Daiki
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Oita, Masataka
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
Kaken ID
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Fukunaga, Jun-Ichi
Division of Radiology, Department of Medical Technology, Kyushu University Hospital
Hirose, Taka-Aki
Division of Radiology, Department of Medical Technology, Kyushu University Hospital
Yoshitake, Tadamasa
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
Sasaki, Motoharu
Graduate School of Biomedical Sciences, Tokushima University
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Abstract | This study evaluated the validity of internal target volumes (ITVs) defined by three- (3DCT) and four-dimensional computed tomography (4DCT), and subsequently compared them with actual movements during treatment. Five patients with upper lobe lung tumors were treated with stereotactic body radiotherapy (SBRT) at 48 Gy in four fractions. Planning 3DCT images were acquired with peak-exhale and peak-inhale breath-holds, and 4DCT images were acquired in the cine mode under free breathing. Cine images were acquired using an electronic portal imaging device during irradiation. Tumor coverage was evaluated based on the manner in which the peak-to-peak breathing amplitude on the planning CT covered the range of tumor motion (± 3 SD) during irradiation in the left–right, anteroposterior, and cranio-caudal (CC) directions. The mean tumor coverage of the 4DCT-based ITV was better than that of the 3DCT-based ITV in the CC direction. The internal margin should be considered when setting the irradiation field for 4DCT. The proposed 4DCT-based ITV can be used as an efficient approach in free-breathing SBRT for upper-lobe tumors of the lung because its coverage is superior to that of 3DCT.
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Keywords | 4DCT
3DCT
Internal target volume
EPID imaging
Stereotactic body radiotherapy
Lung cancer
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Note | The version of record of this article, first published in Radiological Physics and Technology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12194-023-00737-y
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Published Date | 2023-09-15
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Publication Title |
Radiological Physics and Technology
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Volume | volume16
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Issue | issue4
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Publisher | Springer Science and Business Media LLC
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Start Page | 497
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End Page | 505
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ISSN | 1865-0333
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NCID | AA12236881
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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Copyright Holders | © The Author(s) 2023
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File Version | publisher
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DOI | |
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Related Url | isVersionOf https://doi.org/10.1007/s12194-023-00737-y
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License | http://creativecommons.org/licenses/by/4.0/
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Citation | Nakanishi, D., Oita, M., Fukunaga, JI. et al. Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy. Radiol Phys Technol 16, 497–505 (2023). https://doi.org/10.1007/s12194-023-00737-y
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Funder Name |
Okayama University
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