ID | 54819 |
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Author |
Nosaka, Nobuyuki
Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
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Okada, Ayumi
Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Tsukahara, Hirokazu
Department of Pediatrics, Okayama University School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
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Abstract | Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
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Keywords | post-cardiac arrest syndrome
traumatic brain injury
therapeutic hypothermia
oxidative stress
intensive care
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Published Date | 2017-02
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Publication Title |
Acta Medica Okayama
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Volume | volume71
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Issue | issue1
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Publisher | Okayama University Medical School
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Start Page | 1
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End Page | 9
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Amo Type | Review
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Submission Path | amo/vol71/iss1/1
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JaLCDOI |