JaLCDOI | 10.18926/AMO/30810 |
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FullText URL | fulltext.pdf |
Author | Ezawa, Kazuhiko| Yamamura, Masahiro| Matsui, Hideki| Ota, Zensuke| Makino, Hirofumi| |
Abstract | To determine whether the predominant infiltration with memory CD4+T cells in joints is specific to the local immune and inflammatory response in rheumatoid arthritis (RA), the proportions of CD45RA+ or CD45RO+ cells in the CD4+T cell populations in three different compartments (i.e., peripheral blood, synovial fluid, and synovial tissue) from patients with RA and osteoarthritis (OA) were compared by two-color flow-cytometric analysis. In the CD4+T cell population of peripheral blood, the number of CD45RO+ cells was relatively higher than CD45RA+ cells in both RA and OA patients, but their percentages did not differ from those found in healthy individuals. However, the great majority of CD4+T cells present in synovial fluid and synovial tissue were CD45RO-positive and CD45RA-negative in both patient groups; although CD4+T cells infiltrating both the disease compartments were markedly greater in RA joints, their mean percentages of CD45RO+ cells were not significantly different from those in OA joints. These data indicate that an accumulation of CD45RO+ memory CD4+T cells is a generalized phenomenon during local inflammatory responses in both RA and OA joints, and may be due mainly to the propensity of these cells to preferentially transmigrate into the inflamed joint via adhesion molecules as compared with CD45RA+ naive CD4+T cells. |
Keywords | rheumatoid arthritis ostroarthritis CD45RO<sup>+</sup> CD4<sup>+</sup>T cells |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1997-02 |
Volume | volume51 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 25 |
End Page | 31 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 9057932 |
Web of Science KeyUT | A1997WL24600005 |
JaLCDOI | 10.18926/AMO/30733 |
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FullText URL | fulltext.pdf |
Author | Noguchi, Hirofumi| Matsumoto, Shinichi| Matsushita, Masayuki| Kobayashi, Naoya| Tanaka, Koichi| Matsui, Hideki| Tanaka, Noriaki| |
Abstract | The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen is a significant breakthrough that allows the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year ; however, the rate is reduced to 50% at 3 years, attributed to prolonged tacrolimus exposure. Recently, immunosuppression agents such as cyclosporine, mycophenolate mofetil, and the novel agent FTY 720 have been used instead of tacrolimus. Lymphocytedepleting antibodies such as anti-thymocyte globulin, alemtuzumab, and hOKT3gamma 1 (ala, ala) have been launched, and a costimulatory blockade of anti-CD40 monoclonal antibodies and CTLA4-Ig will be attempted in the near future. Moreover, the potential of a novel immunosuppressing peptide could now be realized using new technology called the protein transduction system. In this review, we show some of the most recent contributions to the advancement of knowledge in this field. |
Keywords | islet transplantation steroid-free Edmonton protocol protein transduction syst |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2006-04 |
Volume | volume60 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 71 |
End Page | 76 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 16680182 |
Web of Science KeyUT | 000237001900001 |
JaLCDOI | 10.18926/AMO/30708 |
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FullText URL | fulltext.pdf |
Author | Kuramitsu, Makoto| Matsui, Hideki| Tokuda, Masaaki| Hatase, Osamu| |
Abstract | Two factors from normal rat liver cytoplasm inhibited the proliferation of cultured L-929 fibroblasts. One was arginase, the other was a small molecular weight inhibitor stable to trypsin and heat treatment. The small molecular weight inhibitor inhibited the protein and DNA synthesis of L-cells. Inhibition of DNA synthesis was thought to be secondary to the inhibition of protein synthesis. |
Keywords | cell proliferation growth factor inhibiting factor rat liver cytosol L-cells |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1982-02 |
Volume | volume36 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 10 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 7064729 |
Web of Science KeyUT | A1982NE20000001 |
JaLCDOI | 10.18926/AMO/30465 |
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FullText URL | fulltext.pdf |
Author | Nakamura, Mitsuo| Itano, Toshifumi| Yamaguchi, Fuminori| Mizobuchi, Masayuki| Tokuda, Masaaki| Matsui, Hideki| Etoh, Siji| Hosokawa, Kiyoshi| Ohmoto, Takashi| Hatase, Osamu| |
Abstract | Peptides and proteins in the extracellular space in the central nervous system were investigated in vivo using an intracerebral microdialysis probe. The molecular cut-off of the hollow fiber which was used for the probe was approximately 100 kDa. We examined recovery rates of several compounds in vitro. The recovery rates of proteins and peptides were between 7-28%, with the exceptions of substance P and insulin-like growth factor I. The recovery rates of monoamines and their metabolites were 22-40%. In in vivo studies, two major proteins with apparent molecular weights of 62 kDa and 12 kDa, and several minor proteins (28 kDa, 43 kDa, 52 kDa and 70 kDa) were detected by SDS-polyacrylamide gel electrophoresis in the dialysate from a probe implanted in the striatum of anesthetized rats. These results suggest that the newly developed, intracerebral microdialysis probe might be useful for investigating the dynamic changes of peptides and proteins in the central nervous system. |
Keywords | protein peptide microdialysis extracellular space probe |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 1990-02 |
Volume | volume44 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 8 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 2330841 |
Web of Science KeyUT | A1990CT06800001 |
Author | Matsui, Hideki| |
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Published Date | 2009-12-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume121 |
Issue | issue3 |
Content Type | Journal Article |
Title Alternative | A CACNB4 mutation showing altered Ca(v)2.1 function in a patient with Dravet syndrome |
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FullText URL | 121_149.pdf |
Author | Ohmori, Iori| Ouchida, Mamoru| Mimaki, Nobuyoshi| Nishiki, Teiichi| Tomizawa, Kazuhito| Matsui, Hideki| |
Keywords | てんかん Dravet 症候群 CACNB4遺伝子 SCN1A 遺伝子 |
Publication Title | 岡山医学会雑誌 |
Published Date | 2009-12-01 |
Volume | volume121 |
Issue | issue3 |
Start Page | 149 |
End Page | 156 |
ISSN | 0030-1558 |
language | Japanese |
Copyright Holders | 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.121.149 |
NAID | 120002308814 |
Author | Kuramitsu, Makoto| Itano, Toshifumi| Matsui, Hideki| Tokuda, Masaaki| Hatase, Osamu| Murakami, Tetsuhide| Nisida, Isamu| Hayashi, Hideo| |
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Published Date | 1979-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume91 |
Issue | issue3-4 |
Content Type | Journal Article |
Author | Matsui, Hideki| |
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Published Date | 1982-04-30 |
Publication Title | 岡山医学会雑誌 |
Volume | volume94 |
Issue | issue3-4 |
Content Type | Journal Article |
Author | 野口 洋文| 松下 正之| Kobayashi, Naoya| Susan Bonner-Weir| 松井 秀樹| 田中 紀章| 田中 紘一| 松本 慎一| |
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Published Date | 2005-09-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume117 |
Issue | issue2 |
Content Type | Journal Article |
FullText URL | 118_205.pdf |
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Author | 道上 宏之| 富澤 一仁| 魏 范研| 松下 正之| 陸 雲飛| 市川 智継| 田宮 隆| 松井 秀樹| 伊達 勲| |
Keywords | プロテインセラピー 悪性脳腫瘍 p 53 エンドソーム 蛋白導入ドメイン |
Publication Title | 岡山医学会雑誌 |
Published Date | 2007-01-04 |
Volume | volume118 |
Issue | issue3 |
Start Page | 205 |
End Page | 208 |
ISSN | 00301558 |
language | Japanese |
Copyright Holders | Copyright© 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma1947.118.3_205 |
NAID | 10018454083 |
Title Alternative | Novel protein transduction method for cerebral arteries using 11R |
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FullText URL | 120_129.pdf |
Author | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
Keywords | cerebral vasospasm 11R protein transduction method |
Publication Title | 岡山医学会雑誌 |
Published Date | 2008-08-01 |
Volume | volume120 |
Issue | issue2 |
Start Page | 129 |
End Page | 133 |
ISSN | 00301558 |
language | Japanese |
Copyright Holders | 岡山医学会 |
File Version | publisher |
DOI | 10.4044/joma.120.129 |
NAID | 120002310545 |
Author | 魏 范研| 長嶋 一昭| 大島 登志男| 佐伯 恭範| 陸 雲飛| 松下 正之| 山田 祐一郎| 御子柴 克彦| 清野 裕| 松井 秀樹| 富澤 一仁| |
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Published Date | 2007-05-01 |
Publication Title | 岡山医学会雑誌 |
Volume | volume119 |
Issue | issue1 |
Content Type | Journal Article |
Author | 松井 秀樹| |
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Published Date | 1982-03-31 |
Publication Title | |
Content Type | Thesis or Dissertation |