FullText URL | fulltext20240904-02.pdf |
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Author | Asanuma, Masato| Miyazaki, Ikuko| Funada, Masahiko| |
Keywords | Psychoactive drugs 2,5-Dimethoxy-substituted phenethylamines Neurotoxicity Serotonin-containing neurons Dopamine neurons Reactive oxygen species |
Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11419-020-00527-w| |
Published Date | 2020-02-21 |
Publication Title | Forensic Toxicology |
Volume | volume38 |
Issue | issue2 |
Publisher | Springer Science and Business Media LLC |
Start Page | 394 |
End Page | 408 |
ISSN | 1860-8965 |
NCID | AA12435006 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Japanese Association of Forensic Toxicology 2020 |
File Version | author |
DOI | 10.1007/s11419-020-00527-w |
Web of Science KeyUT | 000516475700001 |
Related Url | isVersionOf https://doi.org/10.1007/s11419-020-00527-w |
FullText URL | fulltext20240904-01.pdf |
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Author | Masai, Kaori| Nakayama, Yuta| Shin, Kotaro| Sugahara, Chiaki| Miyazaki, Ikuko| Yasuhara, Takao| Date, Isao| Asanuma, Masato| |
Keywords | Streptozotocin Adult neurogenesis Astrocyte Microglia |
Note | © 2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Dec. 2024.| |
Published Date | 2024-01-18 |
Publication Title | Neuroscience Letters |
Volume | volume820 |
Publisher | Elsevier |
Start Page | 137598 |
ISSN | 0304-3940 |
NCID | AA00754925 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier B.V. |
File Version | author |
PubMed ID | 38110145 |
DOI | 10.1016/j.neulet.2023.137598 |
Web of Science KeyUT | 001142817500001 |
Related Url | isVersionOf https://doi.org/10.1016/j.neulet.2023.137598 |
FullText URL | fulltext.pdf |
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Author | Murata, Hitoshi| Phoo, May Tha Zin| Ochi, Toshiki| Tomonobu, Nahoko| Yamamoto, Ken-ichi| Kinoshita, Rie| Miyazaki, Ikuko| Nishibori, Masahiro| Asanuma, Masato| Sakaguchi, Masakiyo| |
Keywords | JNK PARK2 Parkinson’sdisease Phosphorylation SARM1 |
Published Date | 2023-09-19 |
Publication Title | The Journal of Biochemistry |
Volume | volume174 |
Issue | issue6 |
Publisher | Oxford University Press (OUP) |
Start Page | 533 |
End Page | 548 |
ISSN | 0021-924X |
NCID | AA00694073 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2023. |
File Version | publisher |
PubMed ID | 37725528 |
DOI | 10.1093/jb/mvad068 |
Web of Science KeyUT | 001079972500001 |
Related Url | isVersionOf https://doi.org/10.1093/jb/mvad068 |
FullText URL | fulltext.pdf |
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Author | Miyazaki, Ikuko| Asanuma, Masato| |
Keywords | metallothionein Parkinson's disease neuroprotection antioxidant metal synuclein astrocyte enteric glial cell |
Published Date | 2023-04-06 |
Publication Title | Antioxidants |
Volume | volume12 |
Issue | issue4 |
Publisher | MDPI |
Start Page | 894 |
ISSN | 2076-3921 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 37107269 |
DOI | 10.3390/antiox12040894 |
Web of Science KeyUT | 000979057300001 |
Related Url | isVersionOf https://doi.org/10.3390/antiox12040894 |
FullText URL | fulltext.pdf |
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Author | Asanuma, Masato| Miyazaki, Ikuko| |
Keywords | glutathione neuroprotection parkinsonism astrocyte region specificity striatum mesencephalon oxidative stress Nrf2 metallothionein serotonin 5-HT1A receptor |
Published Date | 2021-08-13 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume22 |
Issue | issue16 |
Publisher | MDPI |
Start Page | 8689 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. |
File Version | publisher |
PubMed ID | 34445395 |
DOI | 10.3390/ijms22168689 |
Web of Science KeyUT | 000690633200001 |
Related Url | isVersionOf https://doi.org/10.3390/ijms22168689 |
FullText URL | fulltext.pdf |
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Author | Asanuma, Masato| Okumura-Torigoe, Nao| Miyazaki, Ikuko| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| |
Keywords | astrocyte neuroprotection region-specificity striatum mesencephalon oxidative stress 6-hydroxydopamine Nrf2 phase II detoxifying molecules |
Published Date | 2019-01-30 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume20 |
Issue | issue3 |
Publisher | MDPI |
Start Page | 598 |
ISSN | 1422-0067 |
NCID | AA12038549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
PubMed ID | 30704073 |
DOI | 10.3390/ijms20030598 |
Web of Science KeyUT | 000462412500142 |
Related Url | isVersionOf https://doi.org/10.3390/ijms20030598 |
FullText URL | fulltext.pdf |
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Author | Miyazaki, Ikuko| Asanuma, Masato| |
Keywords | astrocyte Parkinson’s disease dopaminergic neuron neuroinflammation neuroprotection alpha-synuclein mitochondria |
Published Date | 2020-12-07 |
Publication Title | Cells |
Volume | volume9 |
Issue | issue12 |
Publisher | MDPI |
Start Page | 2623 |
ISSN | 2073-4409 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 33297340 |
DOI | 10.3390/cells9122623 |
Web of Science KeyUT | 000601806600001 |
Related Url | isVersionOf https://doi.org/10.3390/cells9122623 |
FullText URL | fulltext.pdf |
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Author | Kikuoka, Ryo| Miyazaki, Ikuko| Kubota, Natsuki| Maeda, Megumi| Kagawa, Daiki| Moriyama, Masaaki| Sato, Asuka| Murakami, Shinki| Kitamura, Yoshihisa| Sendo, Toshiaki| Asanuma, Masato| |
Published Date | 2020-11-26 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 20698 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 33244123 |
DOI | 10.1038/s41598-020-77652-4 |
Web of Science KeyUT | 000596329600054 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-77652-4 |
FullText URL | fulltext.pdf |
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Author | Kidani, Naoya| Hishikawa, Tomohito| Hiramatsu, Masafumi| Nishihiro, Shingo| Kin, Kyohei| Takahashi, Yu| Murai, Satoshi| Sugiu, Kenji| Yasuhara, Takao| Miyazaki, Ikuko| Asanuma, Masato| Date, Isao| |
Keywords | apoptosis cerebral blood flow crossed cerebellar diaschisis ischemic stroke oxidative stress |
Published Date | 2020-06-10 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue11 |
Publisher | MDPI |
Start Page | 4137 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32531947 |
DOI | 10.3390/ijms21114137 |
Web of Science KeyUT | 000543400300399 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21114137 |
FullText URL | fulltext.pdf Table&Figs.pdf |
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Author | Miyazaki, Ikuko| Kikuoka, Ryo| Isooka, Nami| Takeshima, Mika| Sonobe, Kanau| Arai, Rei| Funakoshi, Hidemaru| Quin, Kyle E.| Smart, Smart| Zensho, Kazumasa| Asanuma, Masato| |
Keywords | Bisphenol A diglycidyl ether Epoxy resin Brain development Neuronal differentiation Anxiety behavior |
Note | This fulltext is available in March 2021.| |
Published Date | 2020-03-03 |
Publication Title | Food and Chemical Toxicology |
Volume | volume138 |
Publisher | Pergamon |
Start Page | 111235 |
ISSN | 0278-6915 |
NCID | AA10627174 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Elsevier Ltd. |
File Version | author |
PubMed ID | 32142877 |
DOI | 10.1016/j.fct.2020.111235 |
Web of Science KeyUT | 000542938400012 |
Related Url | isVersionOf https://doi.org/10.1016/j.fct.2020.111235 |
FullText URL | fulltext.pdf |
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Author | Miyazaki, Ikuko| Isooka, Nami| Imafuku, Fuminori| Sun, Jin| Kikuoka, Ryo| Furukawa, Chieko| Asanuma, Masato| |
Keywords | rotenone Parkinson's disease dopaminergic neuron dorsal motor nucleus of the vagus myenteric plexus neurodegeneration α-synuclein motor deficit |
Published Date | 2020-05-04 |
Publication Title | International Journal of Molecular Sciences |
Volume | volume21 |
Issue | issue9 |
Publisher | MDPI |
Start Page | 3254 |
ISSN | 1422-0067 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 by the authors. |
File Version | publisher |
PubMed ID | 32375371 |
DOI | 10.3390/ijms21093254 |
Web of Science KeyUT | 000535581700225 |
Related Url | isVersionOf https://doi.org/10.3390/ijms21093254 |
FullText URL | fulltext.pdf |
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Author | Isooka, Nami| Miyazaki, Ikuko| Kikuoka, Ryo| Wada, Kouichi| Nakayama, Erika| Shin, Kotaro| Yamamoto, Daichi| Kitamura, Yoshihisa| Asanuma, Masato| |
Keywords | Astrocyte Dopamine agonist Metallothionein Parkinson's disease Rotigotine Serotonin 1A receptor |
Published Date | 2020-01-31 |
Publication Title | Neurochemistry International |
Volume | volume132 |
Publisher | Elsevier |
Start Page | 104608 |
ISSN | 01970186 |
NCID | AA0032399X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2019 The Authors. Published by Elsevier Ltd. |
File Version | publisher |
PubMed ID | 31765686 |
DOI | 10.1016/j.neuint.2019.104608 |
Web of Science KeyUT | 000508747200014 |
Related Url | isVersionOf https://doi.org/10.1016/j.neuint.2019.104608 |
Author | Asanuma, Masato| Miyazaki, Ikuko| Francisco J., Diaz-Corrales| Higashi, Youichirou| Namba, Masayoshi| Ogawa, Norio| |
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Published Date | 2013-06-12 |
Publication Title | PLOS ONE |
Volume | volume8 |
Issue | issue6 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/53020 |
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FullText URL | 68_6_317.pdf |
Author | Kasahara, Kyosuke| Miyoshi, Ko| Murakami, Shinki| Miyazaki, Ikuko| Asanuma, Masato| |
Abstract | In vertebrates, almost all somatic cells extend a single immotile cilium, referred to as a primary cilium. Increasing evidence suggests that primary cilia serve as cellular antennae in many types of tissues by sensing chemical or mechanical stimuli in the milieu surrounding the cells. In rodents an antibody to adenylyl cyclase 3 (AC3) has been widely used to label the primary cilia of neurons in vivo by immunostaining, whereas the lack of markers for the primary cilia of astrocytes has made it difficult to observe astrocytic primary cilia in vivo. Here, we obtained a visualization of astrocytic primary cilia in the mouse brain. In the somatosensory cortex, a large portion of neurons and astrocytes at postnatal day 10 (P10), and of neurons at P56 had AC3-positive primary cilia, whereas only approx. one-half of the astrocytes in the P56 mice carried primary cilia weakly positive for AC3. In contrast, the majority of astrocytes had ADP-ribosylation factor-like protein 13B (Arl13b)-positive primary cilia in the somatosensory cortex and other brain regions of P56 mice. The lengths of astrocytic primary cilia positive for Arl13b varied among the brain regions. Our data indicate that Arl13b is a noteworthy marker of astrocytic primary cilia in the brain. |
Keywords | primary cilia astrocyte ADP-ribosylation factor-like protein 13B |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2014-12 |
Volume | volume68 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 317 |
End Page | 322 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 25519025 |
Web of Science KeyUT | 000346882200001 |
Author | Murakami, Shinki| Miyazaki, Ikuko| Sogawa, Norio| Miyoshi, Ko| Asanuma, Masato| |
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Published Date | 2014-10 |
Publication Title | Neurotoxicity Research |
Volume | volume26 |
Issue | issue3 |
Content Type | Journal Article |
JaLCDOI | 10.18926/AMO/47009 |
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FullText URL | 65_5_279.pdf |
Author | Miyoshi, Ko| Kasahara, Kyosuke| Miyazaki, Ikuko| Asanuma, Masato| |
Abstract | Almost all mammalian cells carry one primary cilium that functions as a biosensor for chemical and mechanical stimuli. Genetic damages that compromise cilia formation or function cause a spectrum of disorders referred to as ciliapathies. Recent studies have demonstrated that some pharmacological agents and extracellular environmental changes can alter primary cilium length. Renal injury is a well-known example of an environmental insult that triggers cilia length modification. Lithium treatment causes primary cilia to extend in several cell types including neuronal cells;this phenomenon is likely independent of glycogen synthase kinase-3β inhibition. In renal epithelial cell lines, deflection of the primary cilia by fluid shear shortens them by reducing the intracellular cyclic AMP level, leading to a subsequent decrease in mechanosensitivity to fluid shear. Primary cilium length is also influenced by the dynamics of actin filaments and microtubules through the levels of soluble tubulin in the cytosol available for primary cilia extension. Thus, mammalian cells can adapt to the extracellular environment by modulating the primary cilium length, and this feedback system utilizing primary cilia might exist throughout the mammalian body. Further investigation is required concerning the precise molecular mechanisms underlying the control of primary cilium length in response to environmental factors. |
Keywords | primary cilium length lithium cyclic AMP soluble tubulin intraflagellar transport |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2011-10 |
Volume | volume65 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 279 |
End Page | 285 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2011 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 22037264 |
Web of Science KeyUT | 000296116400001 |
JaLCDOI | 10.18926/AMO/40129 |
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FullText URL | 64_4_219.pdf |
Author | Doi, Maho| Miyazaki, Ikuko| Nagamachi, Tomoko| Shinomiya, Kazuaki| Matsunaga, Hisashi| Sendo, Toshiaki| Kawasaki, Hiromu| Asanuma, Masato| Gomita, Yutaka| Kitamura, Yoshihisa| |
Abstract | We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH. |
Keywords | ACTH imipramine lithium proliferation Ki-67 |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2010-08 |
Volume | volume64 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 219 |
End Page | 223 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 20802538 |
Web of Science KeyUT | 000281384400002 |
JaLCDOI | 10.18926/AMO/32105 |
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FullText URL | fulltext.pdf |
Author | Asanuma, Masato| Miyazaki, Ikuko| Diaz-Corrales, Francisco J| Ogawa, Norio| |
Abstract | Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra. A number of gene mutations and deletions have been reported to play a role in the pathogenesis of familial PD. Moreover, a number of pathological and pharmacological studies on sporadic PD and dopaminergic neurotoxin-induced parkinsonism have hypothesized that mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system all play important roles in the pathogenesis and progress of PD. However, these hypotheses do not yet fully explain the mechanisms of dopaminergic neuron-specific cell loss in PD. Recently, the neurotoxicity of dopamine quinone formation by auto-oxidation of dopamine has been shown to cause specific cell death of dopaminergic neurons in the pathogenesis of sporadic PD and dopaminergic neurotoxin-induced parkinsonism. Furthermore, this quinone formation is closely linked to other representative hypotheses in the pathogenesis of PD. In this article, we mainly review recent studies on the neurotoxicity of quinone formation as a dopaminergic neuron-specific oxidative stress and its role in the etiology of PD, in addition to several neuroprotective approaches against dopamine quinone-induced toxicity. |
Keywords | dopamine quinone quinoprotein Parkinson’sdisease oxidative stress neurotoxin |
Amo Type | Article |
Publication Title | Acta Medica Okayama |
Published Date | 2004-10 |
Volume | volume58 |
Issue | issue5 |
Publisher | Okayama University Medical School |
Start Page | 221 |
End Page | 233 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 15666991 |
Web of Science KeyUT | 000224708800001 |
JaLCDOI | 10.18926/AMO/32031 |
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FullText URL | fulltext.pdf |
Author | Aoki, Sogawa Chiharu| Asanuma, Masato| Sogawa, Norio| Miyazaki, Ikuko| Nakanishi, Tohru| Furuta, Hiroaki| Ogawa, Noriko| |
Abstract | The metallothionein (MT) family is a class of low molecular, intracellular, and cysteine-rich proteins with a high affinity for metals. Although the first of these proteins was discovered nearly 40 years ago, their functional significance remains obscure. Four major isoforms (MT-I, MT-II, MT-III, and MT-IV) have been identified in mammals. MT-I and MT-II are ubiquitously expressed in various organs including the brain, while expression of MT-III and MT-IV is restricted in specific organs. MT-III was detected predominantly in the brain, and characterized as a central nervous system-specific isomer. The role of MTs in the central nervous system has become an intense focus of scientific research. An isomer of MTs, MT-III, of particular interest, was originally discovered as a growth inhibitory factor, and has been found to be markedly reduced in the brain of patients with Alzheimer's disease and several other neurodegenerative diseases. MT-III fulfills unique biological roles in homeostasis of the central nervous system and in the etiology of neuropathological disorders. |
Keywords | neuroprotectin metal transport localization gene expression neurodegenerative disease |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2001-02 |
Volume | volume55 |
Issue | issue1 |
Publisher | Okayama University Medical School |
Start Page | 1 |
End Page | 9 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 11246971 |
Web of Science KeyUT | 000167249900001 |
JaLCDOI | 10.18926/AMO/30980 |
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FullText URL | fulltext.pdf |
Author | Miyazaki, Ikuko| Asanuma, Masato| |
Abstract | Oxidative stress, including the reactive oxygen or nitrogen species generated in the enzymatical oxidationor auto-oxidation of an excess amount of dopamine, is thought to play an important role in dopaminergic neurotoxicity. Dopamine and its metabolites containing 2 hydroxyl residues exert cytotoxicityin dopaminergic neuronal cells, primarily due to the generation of highly reactive dopamine and DOPA quinones. Dopamine and DOPA quinones may irreversibly alter protein function through the formation of 5-cysteinyl-catechols on the proteins. Furthermore, the quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases. Therefore, pathogenic effects of the dopamine quinone have recently focused on dopaminergicneuron-specific oxidative stress. In this article, we primarily review recent studies on the pathogenicity of quinone formation, in addition to several neuroprotective approaches against dopaminequinone-induced dysfunction of dopaminergic neurons. |
Keywords | dopamine quinone quinoprotein methamphetamine Parkinson?s disease L-DOPA |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2008-06 |
Volume | volume62 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 141 |
End Page | 150 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
File Version | publisher |
Refereed | True |
PubMed ID | 18596830 |
Web of Science KeyUT | 000257130300001 |