| ID | 69305 |
| Author |
Morimoto, Kosaku
Department of Internal Medicine, Tsuyama Chuo Hospital
Matsumoto, Kazuyuki
Department of Gastroenterology and Hepatology, Okayama University Hospital
ORCID
Kaken ID
publons
Okuyama, Takaki
Department of Internal Medicine, Tsuyama Chuo Hospital
Kimura, Shogo
Department of Internal Medicine, Tsuyama Chuo Hospital
Takei, Kensuke
Department of Internal Medicine, Tsuyama Chuo Hospital
Satomi, Takuya
Department of Internal Medicine, Tsuyama Chuo Hospital
Okada, Tsuyoshi
Department of Surgery, Tsuyama Chuo Hospital
Shinoura, Susumu
Department of Surgery, Tsuyama Chuo Hospital
Shibata, Rei
Department of Diagnostic Pathology, Tsuyama Chuo Hospital
Takenaka, Ryuta
Department of Internal Medicine, Tsuyama Chuo Hospital
|
| Abstract | We report a case of obstructive jaundice due to recurrent distal biliary stricture during 3 years of treatment for immunoglobulin G4 (IgG4)-related sclerosing cholangitis (IgG4-SC) associated with autoimmune pancreatitis. Although a relapse of IgG4-SC was initially suspected, imaging findings, laboratory tests, and histopathological examinations led to the diagnosis of metachronous cholangiocarcinoma. The patient underwent pancreaticoduodenectomy, and no cancer recurrence was noted 6 months postoperatively. Distal cholangiocarcinoma and IgG4-SC remission were observed in the resected specimen. In patients with recurrent biliary strictures during IgG4-SC treatment, comprehensive evaluations are essential because of the risk of disease relapse and development of metachronous cholangiocarcinoma.
|
| Keywords | Autoimmune pancreatitis
IgG4-related sclerosing cholangitis
Cholangiocarcinoma
Metachronous carcinogenesis
|
| Note | The version of record of this article, first published in Clinical Journal of Gastroenterology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12328-025-02211-1
This fulltext file will be available in Sep. 2026.
|
| Published Date | 2025-09-01
|
| Publication Title |
Clinical Journal of Gastroenterology
|
| Publisher | Springer Science and Business Media LLC
|
| ISSN | 1865-7257
|
| NCID | AA12646624
|
| Content Type |
Journal Article
|
| language |
English
|
| OAI-PMH Set |
岡山大学
|
| Copyright Holders | © The Author(s), under exclusive licence to Japanese Society of Gastroenterology 2025
|
| File Version | publisher
|
| PubMed ID | |
| DOI | |
| Related Url | isVersionOf https://doi.org/10.1007/s12328-025-02211-1
|
| Citation | Morimoto, K., Matsumoto, K., Okuyama, T. et al. Metachronic development of cholangiocarcinoma during treatment for IgG4-related sclerosing cholangitis. Clin J Gastroenterol (2025). https://doi.org/10.1007/s12328-025-02211-1
|
