| JaLCDOI | 10.18926/14959 |
|---|---|
| Title Alternative | n-3系脂肪酸食の気管支喘息に対する臨床効果:n-6系脂肪酸との比較 |
| FullText URL | 069_040_048.pdf |
| Author | Okamoto, Makoto| Ashida, Kozo| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Harada, Mine| |
| Abstract | N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation. |
| Keywords | n-3系脂肪酸 (n-3 fatty acids) エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 40 |
| End Page | 48 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308199 |
| JaLCDOI | 10.18926/14956 |
|---|---|
| Title Alternative | MR-angiographyで経過を観察しえた慢性関節リウマチに合併した巨細胞動脈炎の1例 |
| FullText URL | 069_035_039.pdf |
| Author | Harada, Seishi| Mitsunobu, Fumihiro| Kodama, Fumiko| Hosaki, Yasuhiro| Mifune, Takashi| Tsugeno, Hirofumi| Okamoto, Makoto| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| |
| Abstract | We report a patient who developed giant cell (temporal) arteritis during treatment of rheumatoid arthritis. The patient was a 57-year-old Japanese woman and had been well controlled with anti-rheumatic drugs, when she presented to our hospital with severe bitemporal headaches and marked fatigue. An exclusive diagnosis was rapidly made and she was diagnosed as having giant cell arteritis based on the classification criteria by American College of Reumatology. Additionally, magnetic resonance (MR) angiography was performed, from which stenotic change in the bilateral superficial temporal arteries was strongly suspected and then corticosteroid therapy was quickly started. The patient followed an uneventful course without developing any complications such as visual dysfunctions. Therapeutic effect was confirmed by MR-angiographic findings obtained 4 weeks after the initiation of therapy. |
| Keywords | 巨細胞動脈炎 (giant cell arteritis) 側頭動脈炎 (temporal arteritis) 慢性関節リウマチ (rheumatoid arthritis) MRアンギオグラフィー (MR-angiography) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 35 |
| End Page | 39 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308121 |
| JaLCDOI | 10.18926/14955 |
|---|---|
| Title Alternative | 気管支喘息患者における努力肺活量(% FVC)の低下と気道炎症ならびに臨床病型との関連 |
| FullText URL | 069_028_034.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| |
| Abstract | Clinical features of asthmatics with a low % FVC (<80%) were studied in relation to airway inflammation and clinical asthma types. 1. Twenty four (75.0%) of the 32 subjects with a low % FVC had steroid-dependent intractable asthma. 2. A significant association between % FVC value and clinical asthma type was found. The value of % FVC was significantly lower in subjects with type II asthma (bronchiolar obstruction), in which significantly decreased proportion of lymphocytes,and significantly increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid were observed, than in those with type la-1 (simple bronchoconstriction) with (P<0.001) and without glucocorticoid therapy (P<0.02). 3. The % FVC value was significantly improved after treatment in type lb (hypersecretion) with BAL eosinophilia, but not in those with type II with BAL neutrophilia. These results demonstrate that marked decrease of % FVC in patients with asthma correlated with airway inflammation, and that airway reversibility by medication is very low in patients with type II asthma. |
| Keywords | ventilatory function FEV1.0 bronchoalveolar lavage bronchial reversibility |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 28 |
| End Page | 34 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308252 |
| JaLCDOI | 10.18926/14954 |
|---|---|
| Title Alternative | 肺気腫患者における吸入抗原に対するIgE抗体 |
| FullText URL | 069_021_027.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Hasegawa, Harumi| |
| Abstract | To analyze the pathophysiological changes ot the airways in emphysema, bronchial responsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leucocytes were examined in 22 patients with emphysema. The subjects were divided into two groups according to the presence or absence of IgE antibodies against inhalant allergens; RAST positive group and RAST negative group. 1. Smoking history, mean CT number and mean maximum % low attenuation area (% LAA) <-950HU of the lung on high resolution computed tomography (HRCT), and DLco value suggested that there were emphysematous changes of the lung in all subjects. However, these findings were not different between the two groups. 2. The level of serum IgE was significantly higher in RAST positive group than in RAST negative group. 3. The mean % increase in FEV1.0 after inhalation of β-agonists was higher in RAST positive group than in RAST negative group. The % increase more than 15% was found in 4 of the 9 subjects (44.4%) in RAST positive group and 2 of the 12 (16.7%) in RAST negative group. 4. The generation of LTC4 by leucocytes was significantly higher in RAST positive group than in RAST negative group (p<0.01). The generation of LTB4 was not significantly different between the two groups. The results suggest that IgE-mediated allergy participates in the bronchial responsiveness of patients with emphysema. |
| Keywords | emphysema bronchial responsiveness FEV1.0 LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 21 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308178 |
| JaLCDOI | 10.18926/14953 |
|---|---|
| Title Alternative | 肺気腫患者におけるロイコトリエンB4,C4産生能と高分解能CTによる平均CT値との関連 |
| FullText URL | 069_015_020.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Ochi, Koji| Harada, Hideo| Hasegawa, Harumi| |
| Abstract | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease. |
| Keywords | emphysema mean CT number LTB4 LTC4 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 15 |
| End Page | 20 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308094 |
| JaLCDOI | 10.18926/14951 |
|---|---|
| Title Alternative | 気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生能 |
| FullText URL | 069_009_014.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Ochi, Koji| Harada, Hideo| |
| Abstract | The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 16 patients with asthma (8 with atopic and 8 with nonatopic asthma) and 12 healthy controls. 1. The LT84 generation by leucocytes was not significantly different between patients with asthma and healthy controls. The generation of LTC4 was significantly larger in patients with asthma than in healthy controls. The LTC4 generation was also significantly larger in patients with attacks (58.4 ± 38.5 ng/5x10(6) cells) than in those without attacks (23.3 ± 25.9 ng/5x10(6) cells)(p<0.05). 2.ln atopic asthma, the LTC4 production was significantly larger in patients with attacks (84.7 ± 35.4 ng/5x10(6) cells) compared to the production in those without attacks (40.4 ± 27.2 ng/5x10(6) cells)(p<0.02). However, the production of LTB4 was not significantly different between attack and attack-free stages. 3. In nonatopic asthma, the LTC4 production was also significantly higher in patients with attacks (32.2 ± 26.3 ng/5x10(6) cells) than in those without attacks (12.2 ± 3.5 ng/5x10(6) cells)(p<0.05). However, the LTB4 production was not significantly different between attack and nonattack stages. 4. The LTC4 production was significantly larger in atopic asthmatics compared to the production in nonatopic subjects both in attack and nonattack stages. These results suggest that the generation of LTC4 by leucocytes of patients with asthma is closely related to IgE-mediated reaction and asthma attacks. |
| Keywords | bronchial asthma LTB4 LTC4 IgE-mediated reaction asthma attacks |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 9 |
| End Page | 14 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308181 |
| JaLCDOI | 10.18926/14950 |
|---|---|
| Title Alternative | Clinical significance of spa therapy in the treatmentof patients with chronic obstructive pulmonary disease (COPD). A study on 511 patients with COPD admitted for last 5 years |
| FullText URL | 069_001_008.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Yumoto, Eiichiro| Takata, Shingo| Ochi, Koji| Harada, Hideo| |
| Abstract | 1993年1月より1997年12月までの5ヵ年間に当院へ入院した慢性閉塞性呼吸器疾患511例を対象に,疾患の種類,年齢,地域分布などについて検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は594例で,このうち,慢性閉塞性呼吸器疾患患者は511例(86.0%)であった｡これらの慢性閉塞性呼吸器疾患のなかでは,気管支喘息が416例(81.4%)と最も多く,その他.慢性気管支炎20例,閉塞性細気管支炎27例,肺気腫48例であった｡2.慢性閉塞性呼吸器疾患のなかでは,肺気腫の症例が増加する傾向が見られた｡3.慢性閉塞性呼吸器疾患の年齢別検討では,鳥取県内では,70才以上の症例が,また遠隔地(鳥取県外)では60-69才の症例の頻度が高い傾向が見られた｡4.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,その比率は1997年度で48.4%であった｡また,その分布別検討では,岡山県,兵庫県,大阪府,広島県,山口県,愛媛県からの入院患者が多い傾向が見られた｡ |
| Keywords | 慢性閉塞性呼吸器疾患 (COPD) 気管支喘息 (bronchial asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1998-12 |
| Volume | volume69 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308114 |
| JaLCDOI | 10.18926/14943 |
|---|---|
| Title Alternative | Interferon and pancreatitis |
| FullText URL | 070_084_087.pdf |
| Author | Ochi, Koji| Matsumura, Naoki| Mizushima, Takaaki| Hasuoka, Hideaki| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | インターフェロンは慢性肝炎や悪性腫瘍の治療など,広く臨床の場に用いられるようになった｡その副作用の一つとして,膵炎があり,その多くは急性膵炎である,慢性膵炎の報告もあり,膵炎はインターフェロンを用いる場合に知っておくべき副作用である｡そこで,膵炎とインターフェロンの関係について現在までに知られている知見について概説する｡ |
| Keywords | インターフェロン (interferon) 急性膵炎 (acute pancreatitis) 慢性膵炎 (chronic pancreatitis) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 84 |
| End Page | 87 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308150 |
| JaLCDOI | 10.18926/14942 |
|---|---|
| Title Alternative | 臨床的および実験的側面からみた慢性膵炎とフリーラジカル |
| FullText URL | 070_079_083.pdf |
| Author | Ochi, Koji| Matsumura, Naoki| Mizushima, Takaaki| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | Free radicals have been suspected to play an important role in the pathogenicity of chronic pancreatitis. We reviewed studies on free radicals in chronic pancreatitis in both c1inical and experimental aspects. Many clinical studies have provided circumstantial evidence for the close relation between free radicals and chronic pancreatitis. However, few experimental studies in animals on relation between free radicals and chronic pancreatitis have been reported, because adequate experimental models for elucidating a pathological role of free radicals in chronic pancreatitis have not been established. The research concerning the role of free radicals in chronic pancreatitis is expected to improve our understanding the pathological mechanisms of the disease. |
| Keywords | 慢性膵炎 (chronic pancreatitis) フリーラジカル (free radicals) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 79 |
| End Page | 83 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308147 |
| JaLCDOI | 10.18926/14936 |
|---|---|
| Title Alternative | 腰椎MRI画像と腰痛の関係 |
| FullText URL | 070_067_072.pdf |
| Author | Takata, Shingo| Yumoto, Eiichirou| Okamoto, Makoto| Tsugeno, Hirofumi| Harada, Seishi| Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Harada, Mine| |
| Abstract | The purpose of this study was to examine the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP). The study group, 19 patients with low back pain (2 subjects aged 32-39 years and 17 aged 59-78), underwent MRI of the lumbar spine. Disc degeneration at L4/5 was the most common finding (68.4%). Overall in present study, all patients with LBP had abnormalities around the lumbar spine (evidence of disc degeneration, deformity of lumbar spine, disc bulging or protrusion, facet hypertrophy, nerve root compression and so on). |
| Keywords | MRI (Magnetic resonance imaging) 腰椎 (Lumbar spine) 椎間板変性 (Disc disease) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 67 |
| End Page | 72 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308559 |
| JaLCDOI | 10.18926/14935 |
|---|---|
| Title Alternative | A Case of Recurrent Churg-Strauss Syndrome Associated with Bronchial Asthma |
| FullText URL | 070_061_066.pdf |
| Author | Harada, Seishi| Tsugeno, Hirofumi| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Okamoto, Makoto| Takata, Shingo| Yamamoto, Toshio| Tanizaki, Yoshiro| |
| Abstract | 入院中にChurg-Strauss症候群の再燃を来した症例を報告した｡症例は気管支喘息を有する73歳の女性で,持続する両下肢の知覚障害を主訴に当院に入院した｡入院2週頃より微熱,下腹部不快感が続き右下肢のdrop foot,下血を呈した｡末梢血では著明な好酸球増多を認め,内視鏡検査で直腸潰瘍を認めた。3年前の両下肢の知覚障害出現時にも同様の症状を経験しており,Churg-Strauss症候群の再燃と診断し,ステロイド治療を開始することにより新たな後遺症を残すことなく寛解に至った｡Churg-Strauss症候群の発症･再燃の機序を考える上で貴重な症例と考え,文献的考察を加え報告する｡ |
| Keywords | Churg-Strauss症候群 (Churg-Strauss syndrome) アレルギー性肉芽腫性血管炎 (allergic granulomatous angiitis) 血管炎症候群 (vasculitis syndrome) 気管支喘息 (bronchial asthma) 好酸球増多 (eosinophilia) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 61 |
| End Page | 66 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308532 |
| JaLCDOI | 10.18926/14934 |
|---|---|
| Title Alternative | 気管支喘息症例における皮質骨海綿化 |
| FullText URL | 070_053_060.pdf |
| Author | Tsugeno, Hirofumi| Nakai, Mutsuro| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Hosaki, Yasuhiro| Akiyama, Tsuneo| Tsuji, Takao| Tanizaki, Yoshiro| |
| Abstract | In previous studies, we have demonstrated that chronic administration of systemic glucocorticoids decreases cortical bone mineral density (BMD), cortical bone volume, bone strength, and induces development of pathologic fractures in asthmatic patients. We have also demonstrated that glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites in postmenopausal asthmatic patients. There is a difference of gonadal hormones between male and female. To investigate the influence of hormonal difference on glucocorticoid-induced cortical bone porosity, we studied cortical bone volume and BMD in both male and female patients with asthma in this report. A total of 99 asthmatic patients (male 26 cases, female 73 cases) were enrolled in the study. Peripheral quantitative computed tomography (pQCT) was used to measure cortical BMD and relative cortical volume. The cortical volume-density relationship appeared to remain constant regardless of the level of systemic glucocorticoid administration, age or sex, suggesting cortical bone porosity causes similar and simultaneous decreases in cortical bone volume and density. In conclusion, glucocorticoid administration appears to be responsible for the process of cortical bone porosity at both endosteal and intracortical sites despite the gonadal hormonal differences. |
| Keywords | bronchial asthma systemic glucocorticoid cortical bone cortical porosity peripheral quantitative computed tomography |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 53 |
| End Page | 60 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308477 |
| JaLCDOI | 10.18926/14933 |
|---|---|
| Title Alternative | 気管支喘息患者における白血球ロイコトリエン産生能に対する不飽和脂肪酸食の効果に影響する因子 |
| FullText URL | 070_043_052.pdf |
| Author | Okamoto, Makoto| Mitsunobu, Fumihiro| Ashida, Kozo| Mifune, Takashi| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Harada, Seishi| Takada, Shingo| Tanizaki, Yoshiro| Kataoka, Mikio| Niiya, Kenji| Harada, Mine| |
| Abstract | Dietary supplementation with perilla seed oil, a vegetable oil rich in α -lin- olenic acid, inhibits the generation of leukotrienes(LTs) by leucocytes in patients with bronchial asthma. We examined the factors that affect the suppression of LT generation by leucocytes with perilla seed oil-rich supplementation in patients with asthma, by comparing the clinical features of patients with asthma, whose generation of leukotriene (LT) C4 was suppressed by dietary supplementation with perilla seed oil (n-3 fatty acids) (group A), with those of patients who showed no suppression of LTC4 generation (group B). Group A showed a significant increase in the generation of LTB4 and L TC4 by leucocytes after corn oil-rich supplementation (n-6 fatty acids), and a significant decrease in the generation of LTB4 and LTC4 after perilla seed oil-rich supplementation (n-3 fatty acid). However, this was not observed in group B. The level of serum IgE and peak expiratory flow (PEF) in group A were significantly higher than in group B. Furthermore, the serum levels of LDL-cholesterol, β-lipoprotein and phospholipid were significantly lower in group A than in group B. These results suggest that the clinical features differ between these two asthmatic populations with respect to suppression of LTB4 and LTC4 generation by n-3 fatty acids in perilla seed oil-rich supplementation. |
| Keywords | エゴマ油 (perilla seed oil) 気管支喘息 (bronchial asthma) ロイコトリエン (leukotrienes) IgE 脂質代謝 (lipometabolism) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 43 |
| End Page | 52 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308623 |
| JaLCDOI | 10.18926/14927 |
|---|---|
| Title Alternative | サーモグラフィーによる体表面温度の測定 3.体表面温度の回復率と末消血流量との相関 |
| FullText URL | 070_036_042.pdf |
| Author | Hosaki, Yasuhiro| Takata, Shingo| Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Tanizaki, Yoshiro| Ochi, Koji| Tsuji, Takao| |
| Abstract | The body surface peripheral circulation in 12 cases, including 9 patients with diabetes mellitus who were suffering coldness, numbness or pain in their feet, and 3
healthy volunteers was examined using Laser-Doppler blood flowmetry. At the same time, the body surface temperature was estimated by thermography. Thermographic results were analyzed quantitatively by calculating a recovery ratio as : Recovery ratio = [Total counts of thermography(Pixels) over temperature (T) after cold loading] ÷ [Initial counts over T before cold loading] x 100(%). The recovery ratio and the blood flow were correlated, r=0.68, p |
| Keywords | サーモグラフィー (thermography) レーザードプラー血流計 (Laser-Doppler blood flowmetry) 糖尿病 (diabetes mellitus) 末梢循環 (peripheral circulation) 冷水負荷 (cold loading) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 36 |
| End Page | 42 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308240 |
| JaLCDOI | 10.18926/14926 |
|---|---|
| Title Alternative | 気管支喘息症例における気道過敏性と鼻腔･副鼻腔疾患の関係に関する検討 |
| FullText URL | 070_028_035.pdf |
| Author | Mifune, Takashi| Takata, Shingo| Okamoto, Makoto| Tsugeno, Hirofumi| Ashida, Kozo| Harada, Seishi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Tanizaki, Yoshiro| Harada, Mine| |
| Abstract | Pathological changes of nasosinus occur often in subjects with bronchial asthma. Coexisting nasosinus lesion may affect pathophysiology of lower respiratory tract in asthmatics. The extent of nasal and sinus lesion was quantified in 17 patients with bronchial asthma, and their relationships to atopic status, asthma severity and bronchial hyperresponsiveness were evaluated in this study. Opacification degree of maxillary sinuses and nasal mucosa thickening were quantified using CT scans. The opacification degree was evaluated as (total opacification area)/(total maxillary sinus area). Although the opacification degree of maxillary sinuses in atopic patients showed no significant difference compared with that in non-atopic patients, maximum nasal mucosa thickening in atopic patients had a significant difference compared with that in non-atopic patients (p=0.028). In severe asthmatics, the opacification degree of maxillary sinuses was significantly more prominent compared with those in moderate and mild asthmatics (p=0.0005, p=0.036, respectively). Significantly marked nasal mucosa thickening was recognized in mild asthmatics compared with that in moderate asthmatics (p=0.0462). Regarding bronchial hyperresponsiveness, a significant correlation between Dmin and the opacification degree of maxillary sinuses was observed (rs= -0.551, p=0.0276). Nasal mucosa thickening had no correlation with bronchial hyperresponsiveness. The results suggest that sinusitis may affect bronchial hyperresponsiveness and asthma severity. Treatment of sinusitis may lead to improvement of asthma symptoms. |
| Keywords | 気管支喘息 (bronchial asthma) 副鼻腔炎 (sinusitis) CT所見 (CT findings) 気道過敏性 (hyperresponsiveness) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 28 |
| End Page | 35 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308098 |
| JaLCDOI | 10.18926/14925 |
|---|---|
| Title Alternative | 気管支喘息における胸部HRCT所見の臨床[光延文裕1]的意義 |
| FullText URL | 070_017_027.pdf |
| Author | Mitsunobu, Fumihiro| Mifune, Takashi| Ashida, Kozo| Hosaki, Yasuhiro| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Nakai, Mutsuo| Tanizaki, Yoshiro| |
| Abstract | The significance of the low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) has not been determined in patients with asthma. We examined the relationship between the percentage of lung area with CT numbers lower than -950HU (% LAA) and the mean CT number in 81 patients with reversible airway obstruction (asthma) and in 22 healthy subjects, as well as the relationship between maximal % LAA and various parameters of pulmonary function, smoking history, disease severity and allergic type in the asthmatic subjects. The mean CT
number was obtained by scans at three anatomic levels, and maximal % LAA was the % LAA which had the largest value of those measured at the three anatomic levels of the lung.
We found that: 1. The mean CT number was closely related to the maximal % LAA of the lungs in all subjects studied (r= -0.916, p |
| Keywords | low attenuation area high resolution computed tomography reversible airway obstruction |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 17 |
| End Page | 27 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308175 |
| JaLCDOI | 10.18926/14922 |
|---|---|
| Title Alternative | Ⅰ型アレルギー反応および副腎皮質ホルモンは気管支喘息における末梢血白血球のロイコトリエンB4およびC4産生に影響をおよぼす |
| FullText URL | 070_009_016.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Ochi, Koji| Koide, Norio| |
| Abstract | The generation. of leukotrienes 84 (LT84) and C4 (LTC4) by leucocytes stimulated with Ca ionophore A23187 was examined in 71 patients with asthma (42 with atopic and 29 with nonatopic asthma) and 23 healthy controls. Of these patients,22 had SDIA (steroid-dependent intractable asthma). 1. The generation of LT84 and LTC4 by leucocytes was significantly more enhanced in patients with atopic, non-SOIA asthma than in healthy subjects, but not in patients with nonatopic asthma. The generation of LT84 and LTC4 in atopic asthma was significantly more decreased in patients with SOIA than in those with non-SOIA. 2. The LTC4 generation was significantly larger in attack stage than in attack-free stage of patients with atopic and nonatopic asthma when they had not SOIA. However, no significant difference was found in LT84 generation between attack and nonattack stages in these patients. 3. In patients with SOIA, no significant differences were observed in the generation of LT84 and LTC4 between attack and nonattack stages. The results suggest that IgE-mediated allergy and asthma attacks enhance and glucocorticoids inhibit the generation of LT84 and LTC4 by leucocytes. |
| Keywords | bronchial asthma LT84 LTC4 IgE-mediated allergy glucocorticoids |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308654 |
| JaLCDOI | 10.18926/14921 |
|---|---|
| Title Alternative | Spa therapy for patients with asthma. A study on 437 patients with asthma admitted for last 5 years. |
| FullText URL | 070_001_008.pdf |
| Author | Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Mifune, Takashi| Hosaki, Yasuhiro| Ashida, Kozo| Tsugeno, Hirofumi| Okamoto, Makoto| Harada, Seishi| Takata, Shingo| Ochi, Koji| |
| Abstract | 1994年1月より1998年12月までの5年間に当院へ入院した呼吸器疾患のなかで気管支喘息を対象に,年齢,地域分布などの経年変化について検討を加えた｡1.最近5年間に当院へ入院した呼吸器疾患患者は664例で,このうち,気管支喘息は437例(65.8% )であった｡呼吸器疾患のなかで気管支喘息に占める割合の経年変化では,1995年度が最も高く(74.4% ),1997,1998年度にはやや低下(ともに60.7% )の傾向が見られた｡2.入院患者の地域分布では,鳥取県内からの入院患者に比べ,遠隔地(鳥取県外)からの入院患者が比較的多く,いずれの年度においても50% 以上(平均57.3% )であった｡また,岡山,大阪,兵庫,広島,山口,愛媛県などからの入院症例が多い傾向か見られた。3.年齢別検討では,いずれの地域においても,高齢者の入院症例か多く,鳥取県内では70才以上の症例の頻度(平均35.1% )が,また遠隔地(鳥取県外)では60-69才の症例の頻度(平均37.7% )が高い傾向か見られた｡ |
| Keywords | 気管支喘息 (asthma) 温泉療法 (spa therapy) 高齢患者 (aged patients) 遠隔地 (distant area) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1999-12 |
| Volume | volume70 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308420 |
| JaLCDOI | 10.18926/14913 |
|---|---|
| Title Alternative | マトリックスメタロプロテアーゼと膵疾患 |
| FullText URL | 071_076_083.pdf |
| Author | Yokoyama, Motohiro| Ochi, Koji| Mizushima, Takaaki| Ichimura, Mitsuko| Tsurumi, Tetsuya| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| |
| Abstract | Matrix metalloproteinases (MMPs) is a family of collagenolytic enzymesand are associated with many pathological conditions. Especially, MMPs have a strong relation with tumor progression and invasion. In this review, we focused on association of MMPs and pancreatic diseases, and a potential treatment of MMPs inhibitors for pancreatic cancer. |
| Keywords | matrix metalloproteinase(MMP) tissue inhibitor of metalloproteinase(TIMP) pancreatic cancer (膵癌) chronic pancreatitis (慢性膵炎) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 76 |
| End Page | 83 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002308587 |
| JaLCDOI | 10.18926/14912 |
|---|---|
| FullText URL | 071_073_075.pdf |
| Author | Ashida, Kozo| Tsugeno, Hirofumi| Hosaki, Yasuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Nishida, Norikazu| Okamoto, Makoto| Takata, Shingo| Tanizaki, Yoshiro| Tsuji, Takao| |
| Abstract | 症例は80才，女性。76才時［平成7年11月］より肝機能異常［アルカリフォスファターゼ高値］を認め，肝機能異常出現1年7ケ月後，血清学的検索で原発性胆汁性肝硬変症が疑われたが，無治療にて外来で経過を観察を行った。アルカリフォスファターゼ値は漸増傾向を示し，トランスアミナーゼ値の異常も伴ってきたため，平成12年11月精査目的で入院。組織検査等で無症候性原発性胆汁性肝硬変症［PBC］と診断した。PBCは中年・女性に好発する疾患で，高齢【特に後期高齢者］での発症は極めて稀である。4年間の自然経過も含め，興味深いと考えられたので報告する。 |
| Keywords | 原発性胆汁性肝硬変症 (primary biliary cirrhosis) 高齢 (elderly) 自然経過 (natural course) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 2001-02-01 |
| Volume | volume71 |
| Start Page | 73 |
| End Page | 75 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002308230 |
