ID | 55379 |
FullText URL | |
Author |
Sada, Ken-ei
Department of Nephrology, Rheumatology, Endocrinology and Metabolism , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
researchmap
Harigai, Masayoshi
Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University
Amano, Koichi
Department of Rheumatology and Clinical Immunology , Saitama Medical Center, Saitama Medical University
Atsumi, Tatsuya
Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine , Hokkaido University
Fujimoto, Shouichi
Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine , Miyazaki University
Yuzawa, Yukio
Department of Nephrology , Fujita Health University School of Medicine
Takasaki, Yoshinari
Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine
Banno, Shogo
Division of Rheumatology and Nephrology, Department of Internal Medicine , Aichi Medical University School of Medicine
Sugihara, Takahiko
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Kobayashi, Masaki
Department of Nephrology , Tokyo Medical University Ibaraki Medical Center
Usui, Joichi
Department of Nephrology, Faculty of Medicine , University of Tsukuba
Yamagata, Kunihiro
Department of Nephrology, Faculty of Medicine , University of Tsukuba
Homma, Sakae
Department of Respiratory Medicine , Toho University Omori Medical Center
Dobashi, Hiroaki
Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine , Kagawa University
Tsuboi, Naotake
Department of Nephrology, Internal Medicine , Nagoya University Graduate School of Medicine
Ishizu, Akihiro
Faculty of Health Sciences , Hokkaido University
Sugiyama, Hitoshi
Department of Chronic Kidney Disease and Peritoneal Dialysis , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
researchmap
Okada, Yasunori
Department of Pathology , Keio University School of Medicine
Arimura, Yoshihiro
Nephrology and Rheumatology, First Department of Internal Medicine , Kyorin University School of Medicine
Matsuo, Seiichi
Department of Nephrology, Internal Medicine , Nagoya University Graduate School of Medicine
|
Abstract | OBJECTIVE:
To compare disease severity classification systems for six-month outcome prediction in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
METHODS:
Patients with newly diagnosed AAV from 53 tertiary institutions were enrolled. Six-month remission, overall survival, and end-stage renal disease (ESRD)-free survival were evaluated.
RESULTS:
According to the European Vasculitis Study Group (EUVAS)-defined disease severity, the 321 enrolled patients were classified as follows: 14, localized; 71, early systemic; 170, generalized; and 66, severe disease. According to the rapidly progressive glomerulonephritis (RPGN) clinical grading system, the patients were divided as follows: 60, grade I; 178, grade II; 66, grade III; and 12, grade IV. According to the Five-Factor Score (FFS) 2009, 103, 109, and 109 patients had ≤1, 2, and ≥3 points, respectively. No significant difference in remission rates was found in any severity classification. The overall and ESRD-free survival rates significantly differed between grades I/II, III, and IV, regardless of renal involvement. Severe disease was a good predictor of six-month overall and ESRD-free survival. The FFS 2009 was useful to predict six-month ESRD-free survival but not overall survival.
CONCLUSIONS:
The RPGN grading system was more useful to predict six-month overall and ESRD-free survival than the EUVAS-defined severity or FFS 2009.
|
Keywords | Antineutrophil cytoplasmic antibody-associated vasculitis
Eosinophilic granulomatosis with polyangiitis
Granulomatosis with polyangiitis
Inception cohort
Microscopic polyangiitis
|
Note | This is an Accepted Manuscript of an article published by Taylor & Francis Group
|
Published Date | 2016-03-11
|
Publication Title |
Modern Rheumatology
|
Volume | volume26
|
Issue | issue5
|
Publisher | Taylor & Francis
|
Start Page | 730
|
End Page | 737
|
ISSN | 1439-7595
|
NCID | AA1157187X
|
Content Type |
Journal Article
|
language |
English
|
OAI-PMH Set |
岡山大学
|
Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
|
File Version | author
|
PubMed ID | |
DOI | |
Web of Science KeyUT | |
Related Url | https://doi.org/10.3109/14397595.2016.1140274
|