ID | 58545 |
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Author |
Murai, Masahito
Graduate School of Natural Science and Technology, Okayama University
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Yamamoto, Masaki
Graduate School of Natural Science and Technology, Okayama University
Takai, Kazuhiko
Graduate School of Natural Science and Technology, Okayama University
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Abstract | An operationally simple and direct rhenium-catalyzed ortho-alkenylation (C-alkenylation) of unprotected phenols with alkynes was developed. The protocol provided ortho-alkenylphenols exclusively, and formation of para- or multiply alkenylated phenols and hydrophenoxylation (O-alkenylation) products were not observed. The [3 + 2 + 1] cycloaddition of phenols and two alkynes via ortho-alkenylation was also demonstrated, in which the alkynes functioned as both two- and one-carbon units. These reactions proceeded with readily available starting materials under neutral conditions without additional ligands.
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Keywords | anti-markovnikov addition
intramolecular hydroarylation
oxidative annulation
gold
hydrophenoxylation
construction
cyclization
vinylation
alkenes
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Published Date | 2019-04-18
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Publication Title |
Organic Letters
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Volume | volume21
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Issue | issue9
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Publisher | American Chemical Society
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Start Page | 3441
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End Page | 3445
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ISSN | 15237060
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NCID | AA11347843
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Content Type |
Journal Article
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language |
English
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OAI-PMH Set |
岡山大学
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File Version | author
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Related Url | isVersionOf https://doi.org/10.1021/acs.orglett.9b01214
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Funder Name |
Ministry of Education, Culture, Sports, Science and Technology
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助成番号 | 18H03911
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