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ID 14901
Eprint ID
14901
FullText URL
Title Alternative
IgG4-related disease
Author
Hiramatsu, Kazuhisa
Asano, Motoi
Matsushita, Koki
Nakamura, Sukio
Koide, Norio
Kataoka, Hitomi
Ochi, Koji
Abstract
IgG4関連疾患は21世紀になって提唱された新しい疾患である。組織学的にはIgG4陽性形質細胞やリンパ球浸潤が涙腺, 唾液腺, 後腹膜, 膵臓, 胆管などで起こり, 臨床的にはMikulicz病, 後腹膜線維症, 自己免疫膵炎, 糖尿病, 原発性硬化性胆管炎類似の胆管病変などを呈する全身性疾患であり, ステロイド治療に対する良好な反応性を認める。その診断基準は確立されておらず, われわれは, ①血清IgG4の高値, ②本疾患に特徴的な臓器の障害(唾液腺,涙腺, 膵臓, 後腹膜), ③組織学的にIgG4陽性形質細胞とリンパ球の浸潤の確認, の3項目のうち2項目以上認めれば, IgG4関連疾患とするという診断基準を提言する。
Abstract Alternative
IgG4-related disease is a new concept which was established in 21st century. Histologically, infiltrations of IgG4-positive plasma cells and lymphocytes occur in the lacrimal gland, salivary gland , retroperitoneum , pancreas , and biliary tract. IgG4-related disease is a systematic disease presenting symptoms such as Mikulicz's disease, retroperitoneal fibrosis, autoimmune pancreatitis, diabetes and sclerotic cholangitis, and oral steroid therapy is effective. In this paper, we propose diagnostic criteria for IgG4-related disease that have not been established yet. If two (or more) of three following features are fulfilled, IgG4-related disease is diagnosed ; elevated levels of serum IgG4, involvement of organs which is characteristic in IgG4-related disease (salivary gland, lacrimal gland, pancreas and retroperitonium) ,histological findings with IgG4-positive plasma cells and lymphocytes.
Keywords
IgG4関連疾患 (IgG4-related disease)
自己免疫膵炎 (autoimmune pancreatitis)
Mikulicz病 (Mikulicz's disease)
後腹膜線維症 (retroperitoneal fibrosis)
Published Date
2008-03-01
Publication Title
岡大三朝医療センター研究報告
Publication Title Alternative
Annual reports of Misasa Medical Center, Okayama University Medical School
Volume
volume76
Publisher
岡山大学医学部附属病院三朝医療センター
Publisher Alternative
Misasa Medical Center, Okayama University Medical School
Start Page
60
End Page
65
ISSN
1348-1258
NCID
AA11840279
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc